Search Results - "SAMUEL, Varman"

Mechanisms for Insulin Resistance: Common Threads and Missing Links by Samuel, Varman T., Shulman, Gerald I.

“…Insulin resistance is a complex metabolic disorder that defies explanation by a single etiological pathway. Accumulation of ectopic lipid metabolites,…”
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Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases by Samuel, Varman T., Shulman, Gerald I.

“…NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic diacylglycerol activates PKC-ε, impairing insulin receptor activation and…”
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The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux by Samuel, Varman T, Shulman, Gerald I

“…Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient energy utilization are exposed to chronic energy surplus. Ectopic…”
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Fructose induced lipogenesis: from sugar to fat to insulin resistance by Samuel, Varman T

“…Increasing consumption of sugars is one of the contributing factors to the obesity epidemic. Both cane sugar and high-fructose corn syrup contain glucose and…”
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The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis by Herman, Mark A, Samuel, Varman T

“…Epidemiological studies link fructose consumption with metabolic disease, an association attributable in part to fructose-mediated lipogenesis. The mechanisms…”
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Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides by Samuel, Varman T, Shulman, Gerald I

“…Insulin resistance is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, and nonalcoholic liver disease. A recent…”
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The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes by Perry, Rachel J., Samuel, Varman T., Petersen, Kitt F., Shulman, Gerald I.

“…Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to…”
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Lipid-induced insulin resistance: unravelling the mechanism by Samuel, Varman T, MD, Petersen, Kitt Falk, MD, Shulman, Gerald I, Prof

“…Summary Insulin resistance has long been associated with obesity. More than 40 years ago, Randle and colleagues postulated that lipids impaired…”
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high-protein diet for reducing body fat: mechanisms and possible caveats by Pesta, Dominik H, Samuel, Varman T

“…High protein diets are increasingly popularized in lay media as a promising strategy for weight loss by providing the twin benefits of improving satiety and…”
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O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability by Ruan, Hai-Bin, Han, Xuemei, Li, Min-Dian, Singh, Jay Prakash, Qian, Kevin, Azarhoush, Sascha, Zhao, Lin, Bennett, Anton M., Samuel, Varman T., Wu, Jing, Yates, John R., Yang, Xiaoyong

“…A major cause of hyperglycemia in diabetic patients is inappropriate hepatic gluconeogenesis. PGC-1α is a master regulator of gluconeogenesis, and its activity…”
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Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype by Ahmadian, Maryam, Abbott, Marcia J., Tang, Tianyi, Hudak, Carolyn S.S., Kim, Yangha, Bruss, Matthew, Hellerstein, Marc K., Lee, Hui-Young, Samuel, Varman T., Shulman, Gerald I., Wang, Yuhui, Duncan, Robin E., Kang, Chulho, Sul, Hei Sook

“…While fatty acids (FAs) released by white adipose tissue (WAT) provide energy for other organs, lipolysis is also critical in brown adipose tissue (BAT),…”
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Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance by Petersen, Max C, Madiraju, Anila K, Gassaway, Brandon M, Marcel, Michael, Nasiri, Ali R, Butrico, Gina, Marcucci, Melissa J, Zhang, Dongyan, Abulizi, Abudukadier, Zhang, Xian-Man, Philbrick, William, Hubbard, Stevan R, Jurczak, Michael J, Samuel, Varman T, Rinehart, Jesse, Shulman, Gerald I

“…Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D), but whether NAFLD plays a causal role in the pathogenesis of T2D is…”
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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase by Madiraju, Anila K., Erion, Derek M., Rahimi, Yasmeen, Zhang, Xian-Man, Braddock, Demetrios T., Albright, Ronald A., Prigaro, Brett J., Wood, John L., Bhanot, Sanjay, MacDonald, Michael J., Jurczak, Michael J., Camporez, Joao-Paulo, Lee, Hui-Young, Cline, Gary W., Samuel, Varman T., Kibbey, Richard G., Shulman, Gerald I.

“…Metformin treatment of rats at physiologically relevant doses inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase. Molecular…”
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Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease by Kumashiro, Naoki, Erion, Derek M, Zhang, Dongyan, Kahn, Mario, Beddow, Sara A, Chu, Xin, Still, Christopher D, Gerhard, Glenn S, Han, Xianlin, Dziura, James, Petersen, Kitt Falk, Samuel, Varman T, Shulman, Gerald I

“…Insulin resistance is associated with nonalcoholic fatty liver disease (NAFLD) and is a major factor in the pathogenesis of type 2 diabetes. The development of…”
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FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis by Kir, Serkan, Beddow, Sara A., Samuel, Varman T., Miller, Paul, Previs, Stephen F., Suino-Powell, Kelly, Xu, H. Eric, Shulman, Gerald I., Kliewer, Steven A., Mangelsdorf, David J.

“…Fibroblast growth factor (FGF) 19 is an enterokine synthesized and released when bile acids are taken up into the ileum. We show that FGF19 stimulates hepatic…”
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Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids by Vatner, Daniel F., Majumdar, Sachin K., Kumashiro, Naoki, Petersen, Max C., Rahimi, Yasmeen, Gattu, Arijeet K., Bears, Mitchell, Camporez, João-Paulo G., Cline, Gary W., Jurczak, Michael J., Samuel, Varman T., Shulman, Gerald I.

“…A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance—wherein insulin fails to suppress hepatic glucose…”
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Metabolic control analysis of hepatic glycogen synthesis in vivo by Nozaki, Yuichi, Petersen, Max C., Zhang, Dongyan, Vatner, Daniel F., Perry, Rachel J., Abulizi, Abudukadier, Haedersdal, Sofie, Zhang, Xian-Man, Butrico, Gina M., Samuel, Varman T., Mason, Graeme F., Cline, Gary W., Petersen, Kitt F., Rothman, Douglas L., Shulman, Gerald I.

“…Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-controlling step responsible for insulin stimulation of glycogen…”
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Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice by Ayala, Julio E, Samuel, Varman T, Morton, Gregory J, Obici, Silvana, Croniger, Colleen M, Shulman, Gerald I, Wasserman, David H, McGuinness, Owen P

“…The Mouse Metabolic Phenotyping Center (MMPC) Consortium was established to address the need to characterize the growing number of mouse models of metabolic…”
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Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice by Camporez, João Paulo G, Jornayvaz, François R, Petersen, Max C, Pesta, Dominik, Guigni, Blas A, Serr, Julie, Zhang, Dongyan, Kahn, Mario, Samuel, Varman T, Jurczak, Michael J, Shulman, Gerald I

“…Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid metabolism and is currently being pursued as a therapeutic agent for insulin…”
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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance by Lyu, Kun, Zhang, Ye, Zhang, Dongyan, Kahn, Mario, ter Horst, Kasper W., Rodrigues, Marcos R.S., Gaspar, Rafael C., Hirabara, Sandro M., Luukkonen, Panu K., Lee, Seohyuk, Bhanot, Sanjay, Rinehart, Jesse, Blume, Niels, Rasch, Morten Grønbech, Serlie, Mireille J., Bogan, Jonathan S., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.

“…Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance (HIR); however, the key lipid species and molecular mechanisms linking…”
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