Search Results - "SAMUEL, CHRISHAN S."

Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity by Mahajan, Rajiv, MD, PhD, Lau, Dennis H., MBBS, PhD, Brooks, Anthony G., PhD, Shipp, Nicholas J., PhD, Manavis, Jim, PhD, Wood, John P.M., D Phil, Finnie, John W., BVSc, PhD, Samuel, Chrishan S., PhD, Royce, Simon G., PhD, Twomey, Darragh J., MBBS, Thanigaimani, Shivshanker, PhD, Kalman, Jonathan M., MBBS, PhD, Sanders, Prashanthan, MBBS, PhD

“…Abstract Background Obesity and atrial fibrillation (AF) are public health issues with significant consequences. Objectives This study sought to delineate the…”
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Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension by Krishnan, Shalini M, Ling, Yeong H, Huuskes, Brooke M, Ferens, Dorota M, Saini, Narbada, Chan, Christopher T, Diep, Henry, Kett, Michelle M, Samuel, Chrishan S, Kemp-Harper, Barbara K, Robertson, Avril A B, Cooper, Matthew A, Peter, Karlheinz, Latz, Eicke, Mansell, Ashley S, Sobey, Christopher G, Drummond, Grant R, Vinh, Antony

“…Abstract Aims Renal inflammation, leading to fibrosis and impaired function is a major contributor to the development of hypertension. The NLRP3 inflammasome…”
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Inflammasomes-A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia by Murthi, Padma, Pinar, Anita A, Dimitriadis, Evdokia, Samuel, Chrishan S

“…Preeclampsia (PE) is a pregnancy-specific multisystem disorder and is associated with maladaptation of the maternal cardiovascular system and abnormal…”
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Immune Mechanisms and Related Targets for the Treatment of Fibrosis in Various Organs by Pinar, Anita A, Samuel, Chrishan S

“…Inflammation and fibrosis are two interrelated disease pathologies with several overlapping components. Three specific cell types, namely macrophages, T helper…”
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Anti-inflammatory effects of adult stem cells in sustained lung injury: a comparative study by Moodley, Yuben, Vaghjiani, Vijesh, Chan, James, Baltic, Svetlana, Ryan, Marisa, Tchongue, Jorge, Samuel, Chrishan S, Murthi, Padma, Parolini, Ornella, Manuelpillai, Ursula

“…Lung diseases are a major cause of global morbidity and mortality that are treated with limited efficacy. Recently stem cell therapies have been shown to…”
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Enhancing the Therapeutic Potential of Mesenchymal Stromal Cell-Based Therapies with an Anti-Fibrotic Agent for the Treatment of Chronic Kidney Disease by Li, Yifang, Ricardo, Sharon D, Samuel, Chrishan S

“…Chronic kidney disease (CKD) affects 1 in 10 members of the general population, placing these patients at an increasingly high risk of kidney failure. Despite…”
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Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury by Moodley, Yuben, Atienza, Daniel, Manuelpillai, Ursula, Samuel, Chrishan S, Tchongue, Jorge, Ilancheran, Sivakami, Boyd, Richard, Trounson, Alan

“…Acute respiratory distress syndrome is characterized by loss of lung tissue as a result of inflammation and fibrosis. Augmenting tissue repair by the use of…”
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Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors by Tapia Cáceres, Felipe, Gaspari, Tracey A., Hossain, Mohammed Akhter, Samuel, Chrishan S.

“…Chronic NLRP3 inflammasome activation can promote fibrosis through its production of interleukin (IL)-1β and IL-18. Conversely, recombinant human relaxin (RLX)…”
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Serelaxin enhances the therapeutic effects of human amnion epithelial cell‐derived exosomes in experimental models of lung disease by Royce, Simon G., Patel, Krupesh P., Mao, WeiYi, Zhu, Dandan, Lim, Rebecca, Samuel, Chrishan S.

“…Background and Purpose There is growing interest in stem cell‐derived exosomes for their therapeutic and regenerative benefits given their manufacturing and…”
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IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages by Scott, Tara E., Lewis, Caitlin V., Zhu, Mingyu, Wang, Chao, Samuel, Chrishan S., Drummond, Grant R., Kemp-Harper, Barbara K.

“…In cardiovascular disease, pathological and protective roles are reported for the Th2 cytokines IL-4 and IL-13, respectively. We hypothesised that differential…”
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A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity by Praveen, Praveen, Wang, Chao, Handley, Thomas N G, Wu, Hongkang, Samuel, Chrishan S, Bathgate, Ross A D, Hossain, Mohammed Akhter

“…Human relaxin-2 (H2 relaxin) is therapeutically very important due to its strong anti-fibrotic, vasodilatory, and cardioprotective effects. Therefore,…”
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Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury by Wise, Andrea F, Williams, Timothy M, Kiewiet, Mensiena B G, Payne, Natalie L, Siatskas, Christopher, Samuel, Chrishan S, Ricardo, Sharon D

“…Mesenchymal stem cells (MSCs) ameliorate injury and accelerate repair in many organs, including the kidney, although the reparative mechanisms and interaction…”
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Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation by Abed, Hany S., MBBS, B Pharm, Samuel, Chrishan S., PhD, Lau, Dennis H., MBBS, PhD, Kelly, Darren J., PhD, Royce, Simon G., PhD, Alasady, Muayad, MBChB, Mahajan, Rajiv, MD, Kuklik, Pawel, PhD, Zhang, Yuan, MD, PhD, Brooks, Anthony G., PhD, Nelson, Adam J., MBBS, Worthley, Stephen G., MBBS, PhD, Abhayaratna, Walter P., MBBS, PhD, Kalman, Jonathan M., MBBS, PhD, Wittert, Gary A., MBChB, MD, Sanders, Prashanthan, MBBS, PhD, FHRS

“…Background Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. Objective To examine the effect of…”
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Intranasal administration of mesenchymoangioblast‐derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease by Royce, Simon G., Rele, Siddharth, Broughton, Brad R. S., Kelly, Kilian, Samuel, Chrishan S.

“…ABSTRACT Structural changes known as airway remodeling (AWR) characterize chronic/severe asthma and contribute to lung dysfunction. Thus, we assessed the in…”
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Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis by Chow, Bryna S Man, Kocan, Martina, Bosnyak, Sanja, Sarwar, Mohsin, Wigg, Belinda, Jones, Emma S, Widdop, Robert E, Summers, Roger J, Bathgate, Ross A D, Hewitson, Tim D, Samuel, Chrishan S

“…Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging as an effective antifibrotic…”
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Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS by Chow, Bryna Suet Man, Chew, Elaine Guo Yan, Zhao, Chongxin, Bathgate, Ross A D, Hewitson, Tim D, Samuel, Chrishan S

“…The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-β1/Smad2 axis, via its cognate receptor,…”
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Induced pluripotent stem cell-derived mesenchymal stem cells reverse bleomycin-induced pulmonary fibrosis and related lung stiffness by Chakraborty, Amlan, Wang, Chao, Hodgson-Garms, Margeaux, Broughton, Brad R.S., Frith, Jessica E., Kelly, Kilian, Samuel, Chrishan S.

“…Idiopathic pulmonary fibrosis (IPF) is characterised by lung scarring and stiffening, for which there is no effective cure. Based on the immunomodulatory and…”
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Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1 by Pinar, Anita A, Yuferov, Alexander, Gaspari, Tracey A, Samuel, Chrishan S

“…The NLRP3 inflammasome produces interleukin (IL)-1β and IL-18, which when chronically activated by transforming growth factor (TGF)-β1, contribute to fibrosis…”
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In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism by Barsha, Giannie, Mirabito Colafella, Katrina M., Walton, Sarah L., Gaspari, Tracey A., Spizzo, Iresha, Pinar, Anita A., Hilliard Krause, Lucinda M., Widdop, Robert E., Samuel, Chrishan S., Denton, Kate M.

“…Loss of ovarian hormones following menopause contributes to the rise in cardiovascular risk with age. Estrogen plays a protective role against hypertension and…”
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The Novel AT2 Receptor Agonist β-Pro7-AngIII Exerts Cardiac and Renal Anti-Fibrotic and Anti-Inflammatory Effects in High Salt-Fed Mice by Wang, Yan, Yodgee, Jonathan, Del Borgo, Mark, Spizzo, Iresha, Nguyen, Levi, Aguilar, Marie-Isabel, Denton, Kate M, Samuel, Chrishan S, Widdop, Robert E

“…A high salt (HS) diet is associated with an increased risk for cardiovascular diseases (CVDs) and fibrosis is a key contributor to the organ dysfunction…”
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