Search Results - "SAMESHIMA, HISAYO"

A microchip flow-chamber system for quantitative assessment of the platelet thrombus formation process by Hosokawa, Kazuya, Ohnishi, Tomoko, Fukasawa, Masashi, Kondo, Taro, Sameshima, Hisayo, Koide, Takehiko, Tanaka, Kenichi A., Maruyama, Ikuro

“…As the pathogenesis of arterial thrombosis often includes platelet thrombus formation (PTF), antiplatelet agents are commonly used for the prevention of…”
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Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model by Hosokawa, Kazuya, Ohnishi, Tomoko, Sameshima, Hisayo, Miura, Naoki, Koide, Takehiko, Maruyama, Ikuro, Tanaka, Kenichi A

“…Dabigatran and rivaroxaban are novel oral anticoagulants that specifically inhibit thrombin and factor Xa, respectively. The aim of this study is to elucidate…”
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Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions by Hosokawa, Kazuya, Ohnishi, Tomoko, Miura, Naoki, Sameshima, Hisayo, Koide, Takehiko, Tanaka, Kenichi A, Maruyama, Ikuro

“…Abstract Introduction Thrombin-mediated activation of human platelets involves the G-protein-coupled protease-activated receptors PAR1 and PAR4. Inhibition of…”
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Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis by Kikuchi, Kiyoshi, Setoyama, Kentaro, Kawahara, Ko-ichi, Nagasato, Tomoka, Terashi, Takuto, Ueda, Koki, Nakanishi, Kazuki, Otsuka, Shotaro, Miura, Naoki, Sameshima, Hisayo, Hosokawa, Kazuya, Harada, Yoichiro, Shrestha, Binita, Yamamoto, Mika, Morimoto-Yamashita, Yoko, Kikuchi, Haruna, Kiyama, Ryoji, Kamikokuryo, Chinatsu, Tancharoen, Salunya, Sakakima, Harutoshi, Morioka, Motohiro, Tanaka, Eiichiro, Ito, Takashi, Maruyama, Ikuro

“…The combination of alteplase, a recombinant tissue plasminogen activator, and edaravone, an antioxidant, reportedly enhances recanalization after acute…”
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Nucleophosmin may act as an alarmin: implications for severe sepsis by Nawa, Yuko, Kawahara, Ko‐ichi, Tancharoen, Salunya, Meng, Xiaojie, Sameshima, Hisayo, Ito, Takashi, Masuda, Yoshiki, Imaizumi, Hitoshi, Hashiguchi, Teruto, Maruyama, Ikuro

“…Nucleophosmin exerts potent biological activities that contribute to systemic inflammation. NPM is a major nucleolar multifunctional protein involved in…”
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Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model by Hosokawa, Kazuya, Ohnishi-Wada, Tomoko, Sameshima-Kaneko, Hisayo, Nagasato, Tomoka, Miura, Naoki, Kikuchi, Kiyoshi, Koide, Takehiko, Maruyama, Ikuro, Urano, Tetsumei

“…Abstract Introduction Despite the proven benefits of thrombolytic therapy with tissue plasminogen activator (t-PA) for peripheral thromboembolism, perfusion…”
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Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells by Kikuchi, Kiyoshi, Kawahara, Ko-ichi, Biswas, Kamal Krishna, Ito, Takashi, Tancharoen, Salunya, Morimoto, Yoko, Matsuda, Fumiyo, Oyama, Yoko, Takenouchi, Kazunori, Miura, Naoki, Arimura, Noboru, Nawa, Yuko, Meng, Xiaojie, Shrestha, Binita, Arimura, Shinichiro, Iwata, Masahiro, Mera, Kentaro, Sameshima, Hisayo, Ohno, Yoshiko, Maenosono, Ryuichi, Yoshida, Yoshihiro, Tajima, Yutaka, Uchikado, Hisaaki, Kuramoto, Terukazu, Nakayama, Kenji, Shigemori, Minoru, Hashiguchi, Teruto, Maruyama, Ikuro

“…High mobility group box-1 (HMGB1), a non-histone DNA-binding protein, is massively released into the extracellular space from neuronal cells after ischemic…”
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Attenuation of LPS-induced iNOS expression by 1,5-anhydro- d-fructose by Meng, Xiaojie, Kawahara, Ko-ichi, Matsushita, Kenji, Nawa, Yuko, Shrestha, Binita, Kikuchi, Kiyoshi, Sameshima, Hisayo, Hashiguchi, Teruto, Maruyama, Ikuro

“…1,5-anhydro- d-fructose (1,5-AF), a monosaccharide formed from starch and glycogen, exhibits antioxidant and antibacterial activity, and inhibits cytokine…”
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HMGB1: A new marker for estimation of the postmortem interval by KIKUCHI, KIYOSHI, KAWAHARA, KO-ICHI, BISWAS, KAMAL KRISHNA, ITO, TAKASHI, TANCHAROEN, SALUNYA, SHIOMI, NAOTO, KODA, YOSHIRO, MATSUDA, FUMIYO, MORIMOTO, YOKO, OYAMA, YOKO, TAKENOUCHI, KAZUNORI, MIURA, NAOKI, ARIMURA, NOBORU, NAWA, YUKO, ARIMURA, SHINICHIRO, JIE, MENG XIAO, SHRESTHA, BINITA, IWATA, MASAHIRO, MERA, KENTARO, SAMESHIMA, HISAYO, OHNO, YOSHIKO, MAENOSONO, RYUICHI, TAJIMA, YUTAKA, UCHIKADO, HISAAKI, KURAMOTO, TERUKAZU, NAKAYAMA, KENJI, SHIGEMORI, MINORU, YOSHIDA, YOSHIHIRO, HASHIGUCHI, TERUTO, MARUYAMA, IKURO

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Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions by Hosokawa, Kazuya, Ohnishi, Tomoko, Sameshima, Hisayo, Miura, Naoki, Ito, Takashi, Koide, Takehiko, Maruyama, Ikuro

“…High residual platelet aggregability and circulating platelet-monocyte aggregates in patients administered aspirin and clopidogrel are associated with…”
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Combined Dabigatran and Antiplatelet Agents Assessed by the Novel Microchip-Based Flow Chamber System by Tanaka, Kenichi, Hosokawa, Kazuya, Ohnishi, Tomoko, Sameshima, Hisayo, Koide, Takehiko, Maruyama, Ikuro

“…Abstract 1167 Evaluation of the overall antithrombotic activity of dabigatran in combination with antiplatelet agents is difficult because plasma-based…”
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Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4 by Kikuchi, Kiyoshi, Tancharoen, Salunya, Matsuda, Fumiyo, Biswas, Kamal Krishna, Ito, Takashi, Morimoto, Yoko, Oyama, Yoko, Takenouchi, Kazunori, Miura, Naoki, Arimura, Noboru, Nawa, Yuko, Meng, Xiaojie, Shrestha, Binita, Arimura, Shinichiro, Iwata, Masahiro, Mera, Kentaro, Sameshima, Hisayo, Ohno, Yoshiko, Maenosono, Ryuichi, Tajima, Yutaka, Uchikado, Hisaaki, Kuramoto, Terukazu, Nakayama, Kenji, Shigemori, Minoru, Yoshida, Yoshihiro, Hashiguchi, Teruto, Maruyama, Ikuro, Kawahara, Ko-ichi

“…Aquaporin-4 (AQP4) plays a role in the generation of post-ischemic edema. Pharmacological modulation of AQP4 function may thus provide a novel therapeutic…”
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Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc by Kawahara, Ko-ichi, Hashiguchi, Teruto, Masuda, Kazuo, Saniabadi, Abbi, Kikuchi, Kiyoshi, Tancharoen, Salunya, Ito, Takashi, Miura, Naoki, Morimoto, Yoko, Biswas, Kamal, Nawa, Yuko, Meng, Xiaojie, Oyama, Yoko, Takenouchi, Kazunori, Shrestha, Binita, Sameshima, Hisayo, Shimizu, Toshiaki, Adachi, Taro, Adachi, Masakazu, Maruyama, Ikuro

“…High mobility group box-1 protein (HMGB1), primarily from the nucleus, is released into the extracellular milieu either passively from necrotic cells or…”
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1,5-Anhydro- d-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-κB p65 phosphorylation by Meng, Xiaojie, Kawahara, Ko-ichi, Nawa, Yuko, Miura, Naoki, Shrestha, Binita, Tancharoen, Salunya, Sameshima, Hisayo, Hashiguchi, Teruto, Maruyama, Ikuro

“…Lipopolysaccharide (LPS) stimulates macrophages by activating NF-κB, which contributes to the release of tumor necrosis factor (TNF)-α and interleukin (IL)-6…”
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1,5-Anhydro-D-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-{kappa}B p65 phosphorylation by Meng Xiaojie, Kawahara, Ko-ichi, Nawa, Yuko, Miura, Naoki, Shrestha, Binita, Tancharoen, Salunya, Sameshima, Hisayo, Hashiguchi, Teruto, Maruyama, Ikuro

“…Lipopolysaccharide (LPS) stimulates macrophages by activating NF-{kappa}B, which contributes to the release of tumor necrosis factor (TNF)-{alpha} and…”
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Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells by Kawahara, Ko-ichi, Hashiguchi, Teruto, Kikuchi, Kiyoshi, Tancharoen, Salunya, Miura, Naoki, Ito, Takashi, Oyama, Yoko, Nawa, Yuko, Biswas, Kamal, Meng, Xiaojie, Morimoto, Yoko, Shrestha, Binita, Sameshima, Hisayo, Maruyama, Ikuro

“…High mobility group box 1 (HMGB1) is a non-histone nuclear protein which is released from the nucleus of activated macrophages into the extracellular space in…”
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New methodological approaches for assessing thrombus formation in cardiovascular disease by Hosokawa, Kazuya, Ohnishi-Wada, Tomoko, Nagasato, Tomoka, Sameshima-Kaneko, Hisayo, Oyamada, Chiaki, Dahlen, Jeffrey

“…Antiplatelet therapy is the mainstay preventive strategy for cardiovascular diseases, and dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor is…”
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HMGB1: A new marker for estimation of the postmortem interval by KIKUCHI, KIYOSHI, KAWAHARA, KO-ICHI, BISWAS, KAMAL KRISHNA, ITO, TAKASHI, TANCHAROEN, SALUNYA, SHIOMI, NAOTO, KODA, YOSHIRO, MATSUDA, FUMIYO, MORIMOTO, YOKO, OYAMA, YOKO, TAKENOUCHI, KAZUNORI, MIURA, NAOKI, ARIMURA, NOBORU, NAWA, YUKO, ARIMURA, SHINICHIRO, JIE, MENG XIAO, SHRESTHA, BINITA, IWATA, MASAHIRO, MERA, KENTARO, SAMESHIMA, HISAYO, OHNO, YOSHIKO, MAENOSONO, RYUICHI, TAJIMA, YUTAKA, UCHIKADO, HISAAKI, KURAMOTO, TERUKAZU, NAKAYAMA, KENJI, SHIGEMORI, MINORU, YOSHIDA, YOSHIHIRO, HASHIGUCHI, TERUTO, MARUYAMA, IKURO

“…Estimation of the postmortem interval (PMI) is one of the most important tasks in forensic medicine. Numerous methods have been proposed for the determination…”
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1,5-Anhydro-D-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-kappaB p65 phosphorylation by Meng, Xiaojie, Kawahara, Ko-ichi, Nawa, Yuko, Miura, Naoki, Shrestha, Binita, Tancharoen, Salunya, Sameshima, Hisayo, Hashiguchi, Teruto, Maruyama, Ikuro

“…Lipopolysaccharide (LPS) stimulates macrophages by activating NF-kappaB, which contributes to the release of tumor necrosis factor (TNF)-alpha and interleukin…”
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