Search Results - "SALEEM, Moin A"

Molecular stratification of idiopathic nephrotic syndrome by Saleem, Moin A.

“…Idiopathic nephrotic syndrome (INS) describes a group of pathologies of the renal glomerulus that result in the classic triad of heavy proteinuria, oedema and…”
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Long-Term Outcomes in IgA Nephropathy by Pitcher, David, Braddon, Fiona, Hendry, Bruce, Mercer, Alex, Osmaston, Kate, Saleem, Moin A, Steenkamp, Retha, Wong, Katie, Turner, A Neil, Wang, Kaijun, Gale, Daniel P, Barratt, Jonathan

“…IgA nephropathy can progress to kidney failure, and risk assessment soon after diagnosis has advantages both for clinical management and the development of new…”
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What is the Role of Soluble Urokinase-Type Plasminogen Activator in Renal Disease? by Saleem, Moin A

“…Soluble urokinase-type plasminogen activator -(suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational…”
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β-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes by Audzeyenka, Irena, Szrejder, Maria, Rogacka, Dorota, Angielski, Stefan, Saleem, Moin A., Piwkowska, Agnieszka

“…Podocytes constitute an external layer of the glomerular filtration barrier, injury to which is a hallmark of renal disease. Mitochondrial dysfunction often…”
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Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice by Beckerman, Pazit, Bi-Karchin, Jing, Park, Ae Seo Deok, Qiu, Chengxiang, Dummer, Patrick D, Soomro, Irfana, Boustany-Kari, Carine M, Pullen, Steven S, Miner, Jeffrey H, Hu, Chien-An A, Rohacs, Tibor, Inoue, Kazunori, Ishibe, Shuta, Saleem, Moin A, Palmer, Matthew B, Cuervo, Ana Maria, Kopp, Jeffrey B, Susztak, Katalin

“…Risk variants of APOL1 associated with human chronic kidney disease have been identified, but causality has been unclear. Transgenic expression in mice now…”
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Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management by Bierzynska, Agnieszka, McCarthy, Hugh J, Soderquest, Katrina, Sen, Ethan S, Colby, Elizabeth, Ding, Wen Y, Nabhan, Marwa M, Kerecuk, Larissa, Hegde, Shivram, Hughes, David, Marks, Stephen, Feather, Sally, Jones, Caroline, Webb, Nicholas J A, Ognjanovic, Milos, Christian, Martin, Gilbert, Rodney D, Sinha, Manish D, Lord, Graham M, Simpson, Michael, Koziell, Ania B, Welsh, Gavin I, Saleem, Moin A

“…Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing etiologies with monogenic disease accounting for 2.9-30% in selected…”
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G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes by Wang, Xiaoxin X, Edelstein, Michal Herman, Gafter, Uzi, Qiu, Liru, Luo, Yuhuan, Dobrinskikh, Evgenia, Lucia, Scott, Adorini, Luciano, D'Agati, Vivette D, Levi, Jonathan, Rosenberg, Avi, Kopp, Jeffrey B, Gius, David R, Saleem, Moin A, Levi, Moshe

“…Obesity and diabetes mellitus are the leading causes of renal disease. In this study, we determined the regulation and role of the G protein-coupled bile acid…”
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TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility by Farmer, Louise K, Rollason, Ruth, Whitcomb, Daniel J, Ni, Lan, Goodliff, Alexander, Lay, Abigail C, Birnbaumer, Lutz, Heesom, Kate J, Xu, Shang-Zhong, Saleem, Moin A, Welsh, Gavin I

“…Mutations in the transient receptor potential channel 6 ( ) gene are associated with an inherited form of FSGS. Despite widespread expression, patients with…”
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Defects of CRB2 Cause Steroid-Resistant Nephrotic Syndrome by Ebarasi, Lwaki, Ashraf, Shazia, Bierzynska, Agnieszka, Gee, Heon Yung, McCarthy, Hugh J., Lovric, Svjetlana, Sadowski, Carolin E., Pabst, Werner, Vega-Warner, Virginia, Fang, Humphrey, Koziell, Ania, Simpson, Michael A., Dursun, Ismail, Serdaroglu, Erkin, Levy, Shawn, Saleem, Moin A., Hildebrandt, Friedhelm, Majumdar, Arindam

“…Nephrotic syndrome (NS), the association of gross proteinuria, hypoalbuminaemia, edema, and hyperlipidemia, can be clinically divided into steroid-sensitive…”
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Nephrin--signature molecule of the glomerular podocyte by Welsh, Gavin I, Saleem, Moin A

“…In recent years there has been an explosion of interest in the glomerular podocyte, which plays a central role in control of glomerular filtration. A host of…”
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Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus by Aulicino, Francesco, Pelosse, Martin, Toelzer, Christine, Capin, Julien, Ilegems, Erwin, Meysami, Parisa, Rollarson, Ruth, Berggren, Per-Olof, Dillingham, Mark Simon, Schaffitzel, Christiane, Saleem, Moin A, Welsh, Gavin I, Berger, Imre

“…CRISPR-based precise gene-editing requires simultaneous delivery of multiple components into living cells, rapidly exceeding the cargo capacity of traditional…”
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Role of Klotho in Hyperglycemia: Its Levels and Effects on Fibroblast Growth Factor Receptors, Glycolysis, and Glomerular Filtration by Typiak, Marlena, Kulesza, Tomasz, Rachubik, Patrycja, Rogacka, Dorota, Audzeyenka, Irena, Angielski, Stefan, Saleem, Moin A, Piwkowska, Agnieszka

“…Hyperglycemic conditions (HG), at early stages of diabetic nephropathy (DN), cause a decrease in podocyte numbers and an aberration of their function as key…”
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Dysregulated autophagy contributes to podocyte damage in Fabry's disease by Liebau, Max C, Braun, Fabian, Höpker, Katja, Weitbrecht, Claudia, Bartels, Valerie, Müller, Roman-Ulrich, Brodesser, Susanne, Saleem, Moin A, Benzing, Thomas, Schermer, Bernhard, Cybulla, Markus, Kurschat, Christine E

“…Fabry's disease results from an inborn error of glycosphingolipid metabolism that is due to deficiency of the lysosomal hydrolase α-galactosidase A. This…”
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A novel method for successful induction of interdigitating process formation in conditionally immortalized podocytes from mice, rats, and humans by Doi, Kotaro, Kimura, Hiroshi, Wada, Takehiko, Tanaka, Tetsuhiro, Hiromura, Keiju, Saleem, Moin A., Inagi, Reiko, Nangaku, Masaomi, Fujii, Teruo

“…Formation of processes in podocytes is regarded as the hallmark of maturity and normal physical condition for the cell. There are many accumulated findings…”
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Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking by Dorison, Aude, Ghobrial, Irene, Graham, Alison, Peiris, Thanushi, Forbes, Thomas A, See, Michael, Das, Mithun, Saleem, Moin A, Quinlan, Catherine, Lawlor, Kynan T, Ramialison, Mirana, Howden, Sara E, Little, Melissa H

“…NPHS2 variants are the most common cause of steroid-resistant nephrotic syndrome in children >1 month old. Missense NPHS2 variants were reported to cause…”
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TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways by Dorval, Guillaume, Kuzmuk, Valeryia, Gribouval, Olivier, Welsh, Gavin I., Bierzynska, Agnieszka, Schmitt, Alain, Miserey-Lenkei, Stéphanie, Koziell, Ania, Haq, Shuman, Benmerah, Alexandre, Mollet, Géraldine, Boyer, Olivia, Saleem, Moin A., Antignac, Corinne

“…Steroid-resistant nephrotic syndrome (SRNS) is characterized by high-range proteinuria and most often focal and segmental glomerulosclerosis (FSGS)…”
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Prorenin Receptor Is Essential for Normal Podocyte Structure and Function by OSHIMA, Yoichi, KINOUCHI, Kenichiro, YAMADA, Taketo, TAKEMOTO, Minoru, SALEEM, Moin A, QUAGGIN, Susan E, ITOH, Hiroshi, ICHIHARA, Atsuhiro, SAKODA, Mariyo, KURAUCHI-MITO, Asako, BOKUDA, Kanako, NARITA, Tatsuya, KUROSAWA, Hideaki, SUN-WADA, Ge-Hong, WADA, Yoh

“…The prorenin receptor is an accessory subunit of the vacuolar H(+)-ATPase, suggesting that it has fundamental functions beyond activation of the local…”
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Hypoxia induces ZEB2 in podocytes: Implications in the pathogenesis of proteinuria by Nakuluri, Krishnamurthy, Mukhi, Dhanunjay, Nishad, Rajkishor, Saleem, Moin A., Mungamuri, Sathish Kumar, Menon, Ram K., Pasupulati, Anil Kumar

“…The glomerular filtration barrier (GFB) plays a critical role in ensuing protein free urine. The integrity of the GFB is compromised during hypoxia that…”
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Nicotine Induces Podocyte Apoptosis through Increasing Oxidative Stress by Lan, Xiqian, Lederman, Rivka, Eng, Judith M, Shoshtari, Seyedeh Shadafarin Marashi, Saleem, Moin A, Malhotra, Ashwani, Singhal, Pravin C

“…Cigarette smoking plays an important role in the progression of chronic kidney disease (CKD). Nicotine, one of the major components of cigarette smoking, has…”
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WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing by Amin, Elianna M., Oltean, Sebastian, Hua, Jing, Gammons, Melissa V.R., Hamdollah-Zadeh, Maryam, Welsh, Gavin I., Cheung, Man-Kim, Ni, Lan, Kase, Satoru, Rennel, Emma S., Symonds, Kirsty E., Nowak, Dawid G., Royer-Pokora, Brigitte, Saleem, Moin A., Hagiwara, Masatoshi, Schumacher, Valérie A., Harper, Steven J., Hinton, David R., Bates, David O., Ladomery, Michael R.

“…Angiogenesis is regulated by the balance of proangiogenic VEGF 165 and antiangiogenic VEGF 165b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor…”
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