Search Results - "SALAZAR, Santiago"

Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease by Salazar, Santiago V., Strittmatter, Stephen M.

“…Soluble oligomers of amyloid-beta (Aβo) are implicated by biochemical and genetic evidence as a trigger for Alzheimer's disease (AD) pathophysiology. A key…”
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Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss by Salazar, Santiago V, Cox, Timothy O, Lee, Suho, Brody, A Harrison, Chyung, Annabel S, Haas, Laura T, Strittmatter, Stephen M

“…Dozens of genes have been implicated in late onset Alzheimer's disease (AD) risk, but none has a defined mechanism of action in neurons. Here, we show that the…”
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Fyn inhibition rescues established memory and synapse loss in Alzheimer mice by Kaufman, Adam C., Salazar, Santiago V., Haas, Laura T., Yang, Jinhee, Kostylev, Mikhail A., Jeng, Amanda T., Robinson, Sophie A., Gunther, Erik C., van Dyck, Christopher H., Nygaard, Haakon B., Strittmatter, Stephen M.

“…Objective Currently no effective disease‐modifying agents exist for the treatment of Alzheimer disease (AD). The Fyn tyrosine kinase is implicated in AD…”
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Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss by Lee, Suho, Salazar, Santiago V, Cox, Timothy O, Strittmatter, Stephen M

“…The intracellular tyrosine kinase Pyk2 (PTK2B) is related to focal adhesion kinase and localizes to postsynaptic sites in brain. Pyk2 genetic variation…”
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Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease by Haas, Laura T, Salazar, Santiago V, Kostylev, Mikhail A, Um, Ji Won, Kaufman, Adam C, Strittmatter, Stephen M

“…Alzheimer's disease-related phenotypes in mice can be rescued by blockade of either cellular prion protein or metabotropic glutamate receptor 5. We sought…”
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Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas by Stretch, Cynthia, Aubin, Jean-Michel, Mickiewicz, Beata, Leugner, Derek, Al-Manasra, Tariq, Tobola, Elizabeth, Salazar, Santiago, Sutherland, Francis R, Ball, Chad G, Dixon, Elijah, Vogel, Hans J, Damaraju, Sambasivario, Baracos, Vickie E, Bathe, Oliver F

“…Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low…”
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Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes by Haas, Laura T., Salazar, Santiago V., Smith, Levi M., Zhao, Helen R., Cox, Timothy O., Herber, Charlotte S., Degnan, Andrew P., Balakrishnan, Anand, Macor, John E., Albright, Charles F., Strittmatter, Stephen M.

“…Metabotropic glutamate receptor 5 (mGluR5) has been implicated in Alzheimer’s disease (AD) pathology. We sought to understand whether mGluR5’s role in AD…”
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Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy by Brody, A Harrison, Nies, Sarah Helena, Guan, Fulin, Smith, Levi M, Mukherjee, Bandhan, Salazar, Santiago A, Lee, Suho, Lam, Tu Kiet T, Strittmatter, Stephen M

“…Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer's disease risk. Neurons express Pyk2 and the protein is required for…”
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Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease by Salazar, Santiago V, Gallardo, Christopher, Kaufman, Adam C, Herber, Charlotte S, Haas, Laura T, Robinson, Sophie, Manson, Jean C, Lee, Michael K, Strittmatter, Stephen M

“…Biochemical and genetic evidence implicate soluble oligomeric amyloid-β (Aβo) in triggering Alzheimer's disease (AD) pathophysiology. Moreover, constitutive…”
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Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model by Wang, Shoutang, Mustafa, Meer, Yuede, Carla M, Salazar, Santiago Viveros, Kong, Philip, Long, Hua, Ward, Michael, Siddiqui, Omer, Paul, Robert, Gilfillan, Susan, Ibrahim, Adiljan, Rhinn, Hervé, Tassi, Ilaria, Rosenthal, Arnon, Schwabe, Tina, Colonna, Marco

“…TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer's disease (AD) risk. In…”
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Chronic Cardiac Herniation: A Peculiar Diagnosis by Ayala Torres, Juan D, Gómez Salazar, Santiago Andrés, Vélez Zuluaga, Juan Gonzalo

“…The presented case describes a 56-year-old male with adult-onset Still's disease, exhibiting polyserositis in 2019, who underwent pleurectomy and…”
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Recombinant Subunit Vaccine Candidate against the Bovine Viral Diarrhea Virus by Avello, Verónica, Salazar, Santiago, González, Eddy E, Campos, Paula, Manríque, Viana, Mathieu, Christian, Hugues, Florence, Cabezas, Ignacio, Gädicke, Paula, Parra, Natalie C, Acosta, Jannel, Sánchez, Oliberto, González, Alaín, Montesino, Raquel

“…Multivalent live-attenuated or inactivated vaccines are often used to control the bovine viral diarrhea disease (BVD). Still, they retain inherent…”
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Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy by Brody, A Harrison, Nies, Sarah Helena, Guan, Fulin, Smith, Levi M, Mukherjee, Bandhan, Salazar, Santiago A, Lee, Suho, Lam, Tu Kiet T, Strittmatter, Stephen M

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Review of Acute Traumatic Closed Mallet Finger Injuries in Adults by Salazar Botero, Santiago, Hidalgo Diaz, Juan Jose, Benaïda, Anissa, Collon, Sylvie, Facca, Sybille, Liverneaux, Philippe André

“…In adults, mallet finger is a traumatic zone I lesion of the extensor tendon with either tendon rupture or bony avulsion at the base of the distal phalanx…”
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New insight into the biological activity of Salmo salar NK-lysin antimicrobial peptides by Ortega, Leonardo, Carrera, Crisleri, Muñoz-Flores, Carolina, Salazar, Santiago, Villegas, Milton F, Starck, María F, Valenzuela, Ariel, Agurto, Niza, Montesino, Raquel, Astuya, Allisson, Parra, Natalie, Pérez, Ercilia T, Santibáñez, Natacha, Romero, Alex, Ruíz, Pamela, Lamazares, Emilio, Reyes, Fátima, Sánchez, Oliberto, Toledo, Jorge R, Acosta, Jannel

“…NK-lysin is a potent antimicrobial peptide (AMP) with antimicrobial activity against bacteria, fungi, viruses, and parasites. NK-lysin is a type of granulysin,…”
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Response of a specialist leaf miner insect to the environmental stress of its host plant by Santiago‐Salazar, César Miguel, Barrera, Juan F., Rojas, Julio C., Huerta‐Palacios, Graciela, Escamilla‐Prado, Esteban

“…The coffee leaf miner, Leucoptera coffeella (Guérin-Mèneville), is one of the main coffee pests ( Coffea spp.) in the Neotropical region. This moth species…”
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The oviposition preference of Leucoptera coffeella is not determined by the cultivar of Coffea arabica, but it may influence some traits of its offspring performance by Santiago-Salazar, César Miguel, Barrera, Juan F., Rojas, Julio C., Huerta-Palacios, Graciela, Escamilla-Prado, Esteban

“…The coffee leaf miner, Leucoptera coffeella (Guérin-Méneville), is one of the main pests of coffee ( Coffea spp.) in the Neotropical region. Leucoptera…”
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Conservative treatment of distal fractures after the age of 65: a review of literature by Bruyere, Alexandra, Vernet, Paul, Botero, Santiago Salazar, Igeta, Yuka, Hidalgo Diaz, Juan José, Liverneaux, Philippe

“…The goal of this study was to evaluate the role of conservative treatment of distal radius fractures in the elderly since 2000. Our series included 22…”
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Anemia frequency in children living at Andean high altitude in Ecuador, Peru, and Bolivia by Garrido-Salazar, David Israel, Garrido-Salazar, Santiago Moisés, Vivas-Armas, Gina

“…OBJECTIVE: To establish the frequency of anemia among children living in the Andean region of Ecuador, Perú, and Bolivia.MATERIALS AND METHODS: A transversal…”
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New Formulation of a Subunit Vaccine Candidate against Lawsonia intracellularis Increases Humoral and Cellular Immune Responses by Salazar, Santiago, Starck, María Francisca, Villegas, Milton F, Acosta, Jannel, Sánchez, Oliberto, Ramos, Eduardo, Nova-Lamperti, Estefanía, Toledo, Jorge R, Gädicke, Paula, Ruiz, Álvaro, González, Alaín, Montesino, Raquel

“…Previously, we designed a subunit vaccine candidate based on three antigens with promising results in pigs. In this study, antigens were produced individually…”
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