Search Results - "SALAZAR, D. E"
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Cytochrome P450 3A Inhibition by Ketoconazole Affects Prasugrel and Clopidogrel Pharmacokinetics and Pharmacodynamics Differently
Published in Clinical pharmacology and therapeutics (01-05-2007)“…Prasugrel and clopidogrel inhibit platelet aggregation through active metabolite formation. Prasugrel's active metabolite (R‐138727) is formed primarily by…”
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2
A simple assay to study social behavior in Drosophila: measurement of social space within a group
Published in Genes, brain and behavior (01-03-2012)“…We have established a new simple behavioral paradigm in Drosophila melanogaster to determine how genes and the environment influence the behavior of flies…”
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3
The Use of Modeling and Simulation to Guide Clinical Development of Olmesartan Medoxomil in Pediatric Subjects
Published in Clinical pharmacology and therapeutics (01-02-2012)“…Modeling and simulation were used extensively in the development of an indication for the use of olmesartan medoxomil in pediatric patients with hypertension…”
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4
Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects
Published in Current medical research and opinion (01-08-2009)“…ABSTRACT Objective: Prasugrel is a thienopyridine antiplatelet agent for the prevention of atherothrombotic events in patients with acute coronary syndrome…”
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5
Pharmacokinetics and pharmacodynamics of prasugrel in subjects with moderate liver disease
Published in Journal of clinical pharmacy and therapeutics (01-10-2009)“…Summary Background and Objective: Prasugrel is a thienopyridine antiplatelet agent under investigation for the prevention of atherothrombotic events in…”
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6
Induction of cytochrome P450IIE1 in the obese overfed rat
Published in Molecular pharmacology (01-03-1991)“…Cytochrome P450IIE1 (IIE1) is a microsomal xenobiotic-activating enzyme that is inducible not only by various chemical agents but also by fasting and diabetes…”
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7
Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end-stage renal disease
Published in Journal of clinical pharmacy and therapeutics (01-10-2009)“…Objective: The pharmacokinetic (PK) and pharmacodynamic (PD) responses to prasugrel were compared in three studies of healthy subjects vs. those with moderate…”
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Coadministration of nefazodone and benzodiazepines. III: A pharmacokinetic interaction study with alprazolam
Published in Journal of clinical psychopharmacology (01-12-1995)“…This study was conducted to determine the potential for an interaction between nefazodone, a new antidepressant, and alprazolam after single- and multiple-dose…”
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9
Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass
Published in The American journal of medicine (01-06-1988)“…Existing methods for predicting creatinine clearance provide accurate estimates for normal-weight patients but not for patients who are obese. Studies into…”
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10
Carbamazepine-nefazodone interaction in healthy subjects
Published in Journal of clinical psychopharmacology (01-02-2000)“…The pharmacokinetic interaction between nefazodone and carbamazepine was investigated in 12 healthy male volunteers. Subjects received nefazodone 200 mg twice…”
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Pharmacokinetic evaluation of co-administration of nefazodone and lithium in healthy subjects
Published in European journal of clinical pharmacology (01-02-1999)“…To evaluate the possible pharmacokinetic interaction between nefazodone and lithium. Twelve healthy volunteers received nefazodone 200 mg b.i.d. for 5 days. A…”
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12
Coadministration of nefazodone and benzodiazepines. I: Pharmacodynamic assessment
Published in Journal of clinical psychopharmacology (01-10-1995)“…One hundred two healthy men were evaluated in one of three studies conducted to evaluate the coadministration of nefazodone, 200 mg twice daily, and three…”
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13
Monitoring of Acute Migraine Attacks: Placebo Response and Safety Data
Published in Headache (01-01-1998)“…In the course of evaluating the safety and efficacy of an investigational compound for acute migraine headaches, a large number of patients received placebo at…”
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14
Evaluation of cerebral pharmacokinetics of the novel antidepressant drug, BMS-181101, by positron emission tomography
Published in The Journal of pharmacology and experimental therapeutics (01-10-1996)“…BMS-181101 is a novel antidepressant drug that is currently under clinical investigation. The goal of this study was to evaluate the pharmacokinetics and…”
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15
Obesity decreases hepatic glutathione concentrations and markedly potentiates allyl alcohol-induced periportal necrosis in the overfed rat
Published in International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity (01-01-1994)“…Liver biopsies from 9 out of every 10 obese individuals exhibit pathological changes of unknown aetiology and 3 out of every 10 reflect severe injury in the…”
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Pharmacokinetics, Tolerability, and Safety of Aripiprazole following Multiple Oral Dosing in Normal Healthy Volunteers
Published in Journal of clinical pharmacology (01-02-2004)“…Two 14‐day, placebo‐controlled, double‐blind studies evaluated the fasting pharmacokinetics, safety, and tolerability of aripiprazole, a new antipsychotic, in…”
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Obesity as a risk factor in drug-induced organ injury. IV. Increased gentamicin nephrotoxicity in the obese overfed rat
Published in The Journal of pharmacology and experimental therapeutics (01-01-1989)“…Obese humans suffer from excessive organ dysfunction, altered drug pharmacokinetics and may be at increased risk of various drug toxicities. A recent report…”
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Pharmacokinetics and Pharmacodynamics of Avitriptan in Patients With Migraine After Oral Dosing
Published in Headache (01-06-1998)“…Avitriptan (BMS‐180048) is a 5‐HT1‐like receptor agonist for the treatment of migraine. This double‐blind, placebo‐controlled, randomized, parallel‐group study…”
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Coadministration of nefazodone and benzodiazepines. IV: A pharmacokinetic interaction study with lorazepam
Published in Journal of clinical psychopharmacology (01-12-1995)“…This study was conducted to determine the potential for an interaction between nefazodone (NEF), a new antidepressant, and lorazepam (LOR) after single- and…”
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20
A Pharmacokinetic-Pharmacodynamic Model of d-Sotalol Q-Tc Prolongation During Intravenous Administration to Healthy Subjects
Published in Journal of clinical pharmacology (01-09-1997)“…The objective of this study was to assess the pharmacokinetics and pharmacodynamics of the dextro (d‐) isomer of sotalol, a class III antiarrhythmic agent, in…”
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