Search Results - "SALAS, José A."

A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols by Fernández-Salas, José A., Manzini, Simone, Nolan, Steven P.

“…A synthetic protocol making use of a well‐defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the…”
Get full text

Antitumor compounds from marine actinomycetes by Olano, Carlos, Méndez, Carmen, Salas, José A

“…Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly…”
Get full text

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering by Olano, Carlos, Lombó, Felipe, Méndez, Carmen, Salas, José A.

“…Production of secondary metabolites is a process influenced by several physico-chemical factors including nutrient supply, oxygenation, temperature and pH…”
Get full text

Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches by Becerril, Adriana, Álvarez, Susana, Braña, Alfredo F, Rico, Sergio, Díaz, Margarita, Santamaría, Ramón I, Salas, José A, Méndez, Carmen

“…Sequencing of Streptomyces genomes has revealed they harbor a high number of biosynthesis gene cluster (BGC), which uncovered their enormous potentiality to…”
Get full text

Volatile communication in Actinobacteria: a language for secondary metabolism regulation by Cuervo, Lorena, Méndez, Carmen, Salas, José A, Olano, Carlos, Malmierca, Mónica G

“…Volatile compounds are key elements in the interaction and communication between organisms at both interspecific and intraspecific levels. In complex bacterial…”
Get full text

Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147 by Prado-Alonso, Laura, Pérez-Victoria, Ignacio, Malmierca, Mónica G, Montero, Ignacio, Rioja-Blanco, Elisa, Martín, Jesús, Reyes, Fernando, Méndez, Carmen, Salas, José A, Olano, Carlos

“…The improvement of genome sequencing techniques has brought to light the biosynthetic potential of actinomycetes due to the large number of gene clusters they…”
Get full text

Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller Streptomyces sp. CS113 by García-Gutiérrez, Coral, Pérez-Victoria, Ignacio, Montero, Ignacio, Fernández-De la Hoz, Jorge, Malmierca, Mónica G, Martín, Jesús, Salas, José A, Olano, Carlos, Reyes, Fernando, Méndez, Carmen

“…Piperazic acid is a cyclic nonproteinogenic amino acid that contains a hydrazine N-N bond formed by a piperazate synthase (KtzT-like). This amino acid, found…”
Get full text

Uncovering the Cryptic Gene Cluster ahb for 3-amino-4-hydroxybenzoate Derived Ahbamycins, by Searching SARP Regulator Encoding Genes in the Streptomyces argillaceus Genome by Ye, Suhui, Molloy, Brian, Pérez-Victoria, Ignacio, Montero, Ignacio, Braña, Alfredo F, Olano, Carlos, Arca, Sonia, Martín, Jesús, Reyes, Fernando, Salas, José A, Méndez, Carmen

“…Genome mining using standard bioinformatics tools has allowed for the uncovering of hidden biosynthesis gene clusters for specialized metabolites in genomes…”
Get full text

The aureolic acid family of antitumor compounds : structure, mode of action, biosynthesis, and novel derivatives by LOMBO, Felipe, MENENDEZ, Nuria, SALAS, José A, MENDEZ, Carmen

“…Members of the aureolic acid family are tricyclic polyketides with antitumor activity which are produced by different streptomycete species. These members are…”
Get full text

New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway by Malmierca, Mónica G, Pérez-Victoria, Ignacio, Martín, Jesús, Reyes, Fernando, Méndez, Carmen, Salas, José A, Olano, Carlos

“…The appearance of new infectious diseases, the increase in multidrug-resistant bacteria, and the need for more effective chemotherapeutic agents have oriented…”
Get full text

Cooperative Involvement of Glycosyltransferases in the Transfer of Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin by Streptomyces sp. Strain CS149 by Malmierca, Mónica G, Pérez-Victoria, Ignacio, Martín, Jesús, Reyes, Fernando, Méndez, Carmen, Olano, Carlos, Salas, José A

“…Macrolactams comprise a family of natural compounds with important bioactivities, such as antibiotic, antifungal, and antiproliferative activities. Sipanmycins…”
Get full text

Chemoselective Ruthenium-Catalysed Reduction of Carboxylic Acids by Fernández-Salas, José A., Manzini, Simone, Nolan, Steven P.

“…A very general and efficient catalytic protocol for the selective reduction of carboxylic acids to their corresponding alcohols under mild conditions is…”
Get full text

Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family by Becerril, Adriana, Pérez-Victoria, Ignacio, Ye, Suhui, Braña, Alfredo F, Martín, Jesús, Reyes, Fernando, Salas, José A, Méndez, Carmen

“…Largimycins are hybrid nonribosomal peptide-polyketides that constitute a new group of metabolites in the leinamycin family of natural products displaying…”
Get full text

Regioselective synthesis of C3 alkylated and arylated benzothiophenes by Shrives, Harry J., Fernández-Salas, José A., Hedtke, Christin, Pulis, Alexander P., Procter, David J.

“…Benzothiophenes are heterocyclic constituents of important molecules relevant to society, including those with the potential to meet modern medical challenges…”
Get full text

Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway by Cano-Prieto, Carolina, García-Salcedo, Raúl, Sánchez-Hidalgo, Marina, Braña, Alfredo F., Fiedler, Hans-Peter, Méndez, Carmen, Salas, José A., Olano, Carlos

“…Streptomyces sp. Tü 6176 produces the cytotoxic benzoxazole nataxazole. Bioinformatic analysis of the genome of this organism predicts the presence of 38…”
Get full text

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074 by Olano, Carlos, García, Ignacio, González, Aranzazu, Rodriguez, Miriam, Rozas, Daniel, Rubio, Julio, Sánchez‐Hidalgo, Marina, Braña, Alfredo F., Méndez, Carmen, Salas, José A.

“…Summary Streptomyces albus J1074 is a streptomycete strain widely used as a host for expression of secondary metabolite gene clusters. Bioinformatic analysis…”
Get full text

Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus by Zabala, Daniel, Braña, Alfredo F., Flórez, Ana B., Salas, José A., Méndez, Carmen

“…Mithramycin (MTM) is a polyketide antitumor compound produced by Streptomyces argillaceus constituted by a tricyclic aglycone with two aliphatic side chains, a…”
Get full text

Volatile Compounds in Actinomycete Communities: A New Tool for Biosynthetic Gene Cluster Activation, Cooperative Growth Promotion, and Drug Discovery by Cuervo, Lorena, Méndez, Carmen, Salas, José A, Olano, Carlos, Malmierca, Mónica G

“…The increasing appearance of multiresistant pathogens, as well as emerging diseases, has highlighted the need for new strategies to discover natural compounds…”
Get full text

Exploring the biocombinatorial potential of benzoxazoles: generation of novel caboxamycin derivatives by Losada, Armando A, Méndez, Carmen, Salas, José A, Olano, Carlos

“…The biosynthesis pathway of benzoxazole compounds caboxamycin and nataxazole have been recently elucidated. Both compounds share one of their precursors,…”
Get full text

Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase by Li, Liyuan, Pan, Guohui, Zhu, Xifen, Fan, Keqiang, Gao, Wubin, Ai, Guomin, Ren, Jinwei, Shi, Mingxin, Olano, Carlos, Salas, José A., Yang, Keqian

“…Glycosyltransferases (GTs)-mediated glycodiversification studies have drawn significant attention recently, with the goal of generating bioactive compounds…”
Get full text