Search Results - "SAKODA, Yukimi"

Improved survival of chimeric antigen receptor‐engineered T (CAR‐T) and tumor‐specific T cells caused by anti‐programmed cell death protein 1 single‐chain variable fragment‐producing CAR‐T cells by Nakajima, Masao, Sakoda, Yukimi, Adachi, Keishi, Nagano, Hiroaki, Tamada, Koji

“…Chimeric antigen receptor‐engineered T (CAR‐T)‐cell therapy holds significant promise for the treatment of hematological malignancies, especially for B‐cell…”
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Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models by Goto, Shunsuke, Sakoda, Yukimi, Adachi, Keishi, Sekido, Yoshitaka, Yano, Seiji, Eto, Masatoshi, Tamada, Koji

“…Chimeric antigen receptor (CAR)-T cell therapy has impressive efficacy in hematological malignancies, but its application in solid tumors remains a challenge…”
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Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment by Umezu, Daisuke, Okada, Nana, Sakoda, Yukimi, Adachi, Keishi, Ojima, Toshiyasu, Yamaue, Hiroki, Eto, Masatoshi, Tamada, Koji

“…Although a role of PD-L1 in the suppression of anti-tumor immunity and its value as a predictive biomarker has been suggested by various preclinical and…”
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Anti‐tumor efficacy of human anti‐c‐met CAR‐T cells against papillary renal cell carcinoma in an orthotopic model by Mori, Jun‐ich, Adachi, Keishi, Sakoda, Yukimi, Sasaki, Takahiro, Goto, Shunsuke, Matsumoto, Hiroaki, Nagashima, Yoji, Matsuyama, Hideyasu, Tamada, Koji

“…Chimeric antigen receptor (CAR)‐T cell therapy has shown salient efficacy in cancer immunotherapy, particularly in the treatment of B cell malignancies…”
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Therapeutic effects of anti‐GM2 CAR‐T cells expressing IL‐7 and CCL19 for GM2‐positive solid cancer in xenograft model by Sasaki, Takahiro, Sakoda, Yukimi, Adachi, Keishi, Tokunaga, Yoshihiro, Tamada, Koji

“…Background While chimeric antigen receptor (CAR)‐T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in…”
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223 CAR-T cells expressing both IL-7 and CCL19 induce epitope spreading via cross presentation of endogenous tumor antigens by Adachi, Keishi, Sakoda, Yukimi, Tamada, Koji

“…BackgroundCAR-T cell therapy against hematological malignancies demonstrated potent therapeutic efficacy, resulting in clinical application of these…”
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Combined adjuvants of poly(I:C) plus LAG‐3‐Ig improve antitumor effects of tumor‐specific T cells, preventing their exhaustion by Kano, Yosuke, Iguchi, Takahiro, Matsui, Hiroto, Adachi, Keishi, Sakoda, Yukimi, Miyakawa, Tomoya, Doi, Shun, Hazama, Shoichi, Nagano, Hiroaki, Ueyama, Yoshiya, Tamada, Koji

“…Therapeutic cancer vaccines are designed to treat cancer by boosting the endogenous immune system to fight against the cancer. In the development of clinically…”
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Dietary Omega-3 Fatty Acids Suppress Experimental Autoimmune Uveitis in Association with Inhibition of Th1 and Th17 Cell Function by Shoda, Hiromi, Yanai, Ryoji, Yoshimura, Takeru, Nagai, Tomohiko, Kimura, Kazuhiro, Sobrin, Lucia, Connor, Kip M, Sakoda, Yukimi, Tamada, Koji, Ikeda, Tsunehiko, Sonoda, Koh-Hei

“…Omega (ω)-3 long-chain polyunsaturated fatty acids (LCPUFAs) inhibit the production of inflammatory mediators and thereby contribute to the regulation of…”
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Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway by Sakoda, Yukimi, Park, Jang-June, Zhao, Yuming, Kuramasu, Atsuo, Geng, Degui, Liu, Yingjia, Davila, Eduardo, Tamada, Koji

“…B and T lymphocyte attenuator (BTLA) is a coinhibitory receptor that interacts with herpesvirus entry mediator (HVEM), and this interaction regulates…”
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Development of cancer immunotherapy by next generation multi-targeting CAR-T cells by Sakoda, Yukimi, Tamada, Koji

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Preventive and therapeutic potential of placental extract in contact hypersensitivity by Kim, Youn Son, Park, Jang-June, Sakoda, Yukimi, Zhao, Yuming, Hisamichi, Katsuya, Kaku, Tai-ichi, Tamada, Koji

“…Immunoregulatory effects of placental extract and placenta-derived factors have been demonstrated in various conditions. Accordingly, placental extract has…”
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IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor by Adachi, Keishi, Kano, Yosuke, Nagai, Tomohiko, Okuyama, Namiko, Sakoda, Yukimi, Tamada, Koji

“…Chimeric antigen receptor (CAR)-T cells expressing the cytokines IL-7 and CCL19 show improved clearance of established solid tumors in mice. Infiltration,…”
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Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity by Omiya, Ryusuke, Tsushima, Fumihiko, Narazaki, Hidehiko, Sakoda, Yukimi, Kuramasu, Atsuo, Kim, Youn, Xu, Haiying, Tamura, Hideto, Zhu, Gefeng, Chen, Lieping, Tamada, Koji

“…Leucocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a membrane receptor of the immunoglobulin (Ig) superfamily that is expressed on most types of…”
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Novel technologies for improving the safety and efficacy of CAR-T cell therapy by Ohta, Keisuke, Sakoda, Yukimi, Tamada, Koji

“…Chimeric antigen receptor-T (CAR-T) cell therapy has shown significant therapeutic efficacy in the treatment of hematological B-cell malignancies. However, the…”
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Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies by TAMADA, Koji, DEGUI GENG, SAKODA, Yukimi, BANSAL, Navneeta, SRIVASTAVA, Ratika, ZHAOYANG LI, DAVILA, Eduardo

“…To develop an adaptable gene-based vector that will confer immune cell specificity to various cancer types. Human and mouse T cells were genetically engineered…”
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Enhanced Antitumor Responses of Tumor Antigen-Specific TCR T Cells Genetically Engineered to Produce IL7 and CCL19 by Tokunaga, Yoshihiro, Sasaki, Takahiro, Goto, Shunsuke, Adachi, Keishi, Sakoda, Yukimi, Tamada, Koji

“…Although adoptive transfer of T cells genetically engineered to express chimeric antigen receptor (CAR) or T-cell receptor (TCR) has been actively developed…”
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B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance by Park, Jang-June, Omiya, Ryusuke, Matsumura, Yumiko, Sakoda, Yukimi, Kuramasu, Atsuo, Augustine, Mathew M., Yao, Sheng, Tsushima, Fumihiko, Narazaki, Hidehiko, Anand, Sudarshan, Liu, Yingjia, Strome, Scott E., Chen, Lieping, Tamada, Koji

“…T-cell tolerance is the central program that prevents harmful immune responses against self-antigens, in which inhibitory PD-1 signal given by B7-H1…”
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Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer by Ohta, Keisuke, Sakoda, Yukimi, Adachi, Keishi, Shinozaki, Taro, Nakajima, Masao, Yasuda, Hiroyuki, Nagano, Hiroaki, Tamada, Koji

“…Cancer immunotherapy using immune checkpoint inhibitors and its combination with other anticancer therapies has emerged as a new standard of care because of…”
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Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease by Sakoda, Yukimi, Hashimoto, Daigo, Asakura, Shoji, Takeuchi, Kengo, Harada, Mine, Tanimoto, Mitsune, Teshima, Takanori

“…Chronic graft-versus-host disease (GVHD) is the most common cause of poor long-term outcomes after allogeneic bone marrow transplantation (BMT), but the…”
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Pathogenic Function of Herpesvirus Entry Mediator in Experimental Autoimmune Uveitis by Induction of Th1- and Th17-Type T Cell Responses by Sakoda, Yukimi, Nagai, Tomohiko, Murata, Sizuka, Mizuno, Yukari, Kurosawa, Hiromi, Shoda, Hiromi, Morishige, Naoyuki, Yanai, Ryoji, Sonoda, Koh-Hei, Tamada, Koji

“…Herpesvirus entry mediator (HVEM), a member of the TNFR superfamily, serves as a unique molecular switch to mediate both stimulatory and inhibitory cosignals,…”
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