Search Results - "SAKER, P. J"

An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes by CASSELL, P. G, NEVEROVA, M, EASLICK, J, RAMACHANDRAN, A, SNEHALATHA, C, PECQUEUR, C, RICQUIER, D, WARDEN, C, HITMAN, G. A, JANMOHAMED, S, UWAKWE, N, QURESHI, A, MCCARTHY, M. I, SAKER, P. J, ALBON, L, KOPELMAN, P, NOONAN, K

“…Linkage between markers close to the uncoupling protein 2 and 3 genes (11q13) and resting metabolic rate and a pre-diabetic phenotype have been found. The…”
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Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin by CASSELL, P. G, SAKER, P. J, SNEHELATHA, C, HITMAN, G. A, MCCARTHY, M. I, HUXTABLE, S. J, KOUSTA, E, JACKSON, A. E, HATTERSLEY, A. T, FRAYLING, T. M, WALKER, M, KOPELMAN, P. G, RAMACHANDRAN, A

“…Uncoupling proteins are mitochondrial transmembrane carriers implicated in the regulation of energy balance. Dysfunction of UCP3 (the predominant uncoupling…”
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Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles by Huxtable, S J, Saker, P J, Haddad, L, Walker, M, Frayling, T M, Levy, J C, Hitman, G A, O'Rahilly, S, Hattersley, A T, McCarthy, M I

“…Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through…”
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UKPDS 21: Low Prevalence of the Mitochondrial Transfer RNA gene (tRNA Leu(UUR)) Mutation at Position 3243bp in UK Caucasian Type 2 Diabetic Patients by Saker, P.J., Hattersley, A.T., Barrow, B., Hammersley, M.S., Horton, V., Gillmer, M.D., Turner, R.C.

“…Some patients with Type 2 (non‐insulin‐dependent) diabetes mellitus possess a mitochondrial mutation in the tRNALeu(UUR) gene at position 3243 bp. These…”
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Glucokinase mutations in a phenotypically selected multiethnic group of women with a history of gestational diabetes by Kousta, E., Ellard, S., Allen, L. I. S., Saker, P. J., Huxtable, S. J., Hattersley, A. T., McCarthy, M. I.

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Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young by ZHANG, Y, COOK, J. T. E, HATTERSLEY, A. T, FIRTH, R, SAKER, P. J, WARREN-PERRY, M, STOFFEL, M, TURNER, R. C

“…Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion…”
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High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population by Saker, P J, Hattersley, A T, Barrow, B, Hammersley, M S, McLellan, J A, Lo, Y M, Olds, R J, Gillmer, M D, Holman, R R, Turner, R C

“…A high proportion of the female patients who are members of maturity onset diabetes of the young (MODY) pedigrees, and whose diabetes mellitus is due to a…”
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Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect? by Gough, S C, Saker, P J, Pritchard, L E, Merriman, T R, Merriman, M E, Rowe, B R, Kumar, S, Aitman, T, Barnett, A H, Turner, R C

“…Recent evidence suggests that a mutation of the glucagon receptor (GCG-R) gene is involved in the development of type 2 diabetes in French patients. We have…”
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Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase by ZHANG, Y, WARREN-PERRY, M, SAKER, P. J, HATTERSLEY, A. T, MACKIE, A. D. R, BAIRD, J. D, GREENWOOD, R. H, STOFFEL, M, BELL, G. I, TURNER, R. C

“…Maturity-onset diabetes of the young (MODY) is a form of non-insulin-dependent diabetes mellitus characterised by an early age of onset and an autosomal…”
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Prohormone convertase 1 in obesity, gestational diabetes mellitus, and NIDDM : No evidence for a major susceptibility role by KALIDAS, K, DOW, E, JOHNSTON, D. G, O'RAHILLY, S, MCCARTHY, M. I, SAKER, P. J, WAREHAM, N, HALSALL, D, JACKSON, R. S, CHAN, S.-P, GELDING, S, WALKER, M, KOUSTA, E

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Microsatellite polymorphisms at the glucokinase locus: a population association study in Caucasian type 2 diabetic subjects by Hattersley, A T, Saker, P J, Cook, J T, Stratton, I M, Patel, P, Permutt, M A, Turner, R C, Wainscoat, J S

“…Glucokinase has a central role in glucose metabolism in pancreatic beta cells and hepatocytes and is an important candidate gene for Type 2 diabetes. Mutations…”
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Mitochondrial FAD-glycerophosphate dehydrogenase and G-protein-coupled inwardly rectifying K+ channel: No evidence for linkage in maturity-onset diabetes of the young or NIDDM by Warren-Perry, M. G., Stoffel, M., Saker, P. J., Zhang, Y., Brown, L. J., MacDonald, M. J., Turner, R. C.

“…Mitochondrial FAD-glycerophosphate dehydrogenase and G-protein-coupled inwardly rectifying K+ channel: No evidence for linkage in maturity-onset diabetes of…”
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Linkage of maturity-onset diabetes of the young to the glucokinase gene--evidence of genetic heterogeneity by Hattersley, A T, Saker, P J, Patel, P, Lo, Y M, Page, R, O'Rahilly, S, Turner, R C, Permutt, M A, Wainscoat, J S

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Mitochondrial FAD-glycerophosphate dehydrogenase and G-protein-coupled inwardly rectifying K+ channel : No evidence for linkage in maturity-onset diabetes of the young or NIDDM by WARREN-PERRY, M. G, STOFFEL, M, SAKER, P. J, ZHANG, Y, BROWN, L. J, MACDONALD, M. J, TURNER, R. C

“…Two genes that have potentially important regulatory roles in insulin secretion are both located on chromosome 2q24.1. G-protein-coupled muscarinic potassium…”
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Studies of Association between the Gene for Calpain-10 and Type 2 Diabetes Mellitus in the United Kingdom by Evans, Julie C., Frayling, Timothy M., Cassell, Paul G., Saker, Philip J., Hitman, Graham A., Walker, Mark, Levy, Jonathan C., O’Rahilly, Stephen, Rao, Pamidighantam V. Subba, Bennett, Amanda J., Jones, Elizabeth C., Menzel, Stephan, Prestwich, Philip, Simecek, Nikol, Wishart, Marie, Dhillon, Ranjit, Fletcher, Chris, Millward, Ann, Demaine, Andrew, Wilkin, Terence, Horikawa, Yukio, Cox, Nancy J., Bell, Graeme I., Ellard, Sian, McCarthy, Mark I., Hattersley, Andrew T.

“…Variation in CAPN10, the gene encoding the ubiquitously expressed cysteine protease calpain-10, has been associated with type 2 diabetes in Mexican Americans…”
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High prevalence of a missence mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population by SAKER, P. J, HATTERSLEY, A. T, BARROW, B, HAMMERSLEY, M. S, MCLELLAN, J.-A, LO, Y.-M. D, OLDS, R. J, GILLMER, M. D, HOLMAN, R. R, TURNER, R. C

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