Search Results - "SAKARELLOS, C."

Synthetic carriers: sequential oligopeptide carriers SOCn-I and SOCn-II as an innovative and multifunctional approach by Alexopoulos, Ch, Sakarellos-Daitsiotis, M, Sakarellos, C

“…Nowadays, the use of synthetic carriers as biochemical reagents and immunogens is entering a new phase. The multimeric nature of these constructs, the…”
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The clinical relevance of antibodies to ribosomal-P common epitope in two targeted systemic lupus erythematosus populations: a large cohort of consecutive patients and patients with active central nervous system disease by Tzioufas, A G, Tzortzakis, N G, Panou-Pomonis, E, Boki, K A, Sakarellos-Daitsiotis, M, Sakarellos, C, Moutsopoulos, H M

“…OBJECTIVES To develop an enzyme linked immunosorbent assay (ELISA) using as substrate a synthetic 22-aminoacid peptide, corresponding to the ribosomal P0, P1…”
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Clinical, immunological, and immunogenetic aspects of autoantibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjögren's syndrome (pSS): a European multicentre study by Tzioufas, A G, Wassmuth, R, Dafni, U G, Guialis, A, Haga, H-J, Isenberg, D A, Jonsson, R, Kalden, J R, Kiener, H, Sakarellos, C, Smolen, J S, Sutcliffe, N, Vitali, C, Yiannaki, E, Moutsopoulos, H M

“…Objectives: To investigate the clinical and immunogenetic aspects of antibody formation against Ro/SSA and La/SSB as well as their linear B cell epitopes in…”
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Calreticulin binds preferentially with B cell linear epitopes of Ro60 kD autoantigen, enhancing recognition by anti‐Ro60 kD autoantibodies by STAIKOU, E. V., ROUTSIAS, J. G., MAKRI, A. A., TERZOGLOU, A., SAKARELLOS‐DAITSIOTIS, M., SAKARELLOS, C., PANAYOTOU, G., MOUTSOPOULOS, H. M., TZIOUFAS, A. G.

“…SUMMARY Calreticulin is a molecular chaperone to newly synthesized polypeptides. Previous studies suggested that calreticulin is probably a protein member of…”
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Highly constrained cyclic (S,S) ‐CXaaC‐ peptides as inhibitors of fibrinogen binding to platelets by KOUKI, A., MITSIOS, J. V., SAKARELLOS‐DAITSIOTIS, M., SAKARELLOS, C., TSELEPIS, A. D., TSIKARIS, V., TSOUKATOS, D. C.

“…The Arg‐Gly‐Asp RGD motif of adhesive proteins is recognized by the activated platelet integrin αIIbβ3. Binding of fibrinogen (Fg) to activated αIIbβ3 causes…”
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The relative orientation of the Arg and Asp side chains defined by a pseudodihedral angle as a key criterion for evaluating the structure-activity relationship of RGD peptides by Kostidis, Sarantos, Stavrakoudis, Athanassios, Biris, Nikolaos, Tsoukatos, Demokritos, Sakarellos, Constantinos, Tsikaris, Vassilios

“…The ability of an integrin to distinguish between the RGD‐containing extracellular matrix proteins is thought to be due partially to the variety of RGD…”
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B-cell autoepitopes on the acetylcholinesterase-homologous region of human thyroglobulin : association with Graves' disease and thyroid eye disease by THRASYVOULIDES, Apollon, SAKARELLOS-DAITSIOTIS, Maria, PHILIPPOU, George, SOUVATZOGLOU, Athanasios, SAKARELLOS, Constantinos, LYMBERI, Peggy

“…Thyroglobulin (Tg) is a large autoantigen involved in autoimmune thyroid diseases. Tg epitopes have, so far, been identified within large peptides. In the…”
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T cell help is required to induce idiotypic–anti‐idiotypic autoantibody network after immunization with complementary epitope 289–308aa of La/SSB autoantigen in non‐autoimmune mice by PAPAMATTHEOU, M. G., ROUTSIAS, J. G., KARAGOUNI, E. E., SAKARELLOS, C., SAKARELLOS‐DAITSIOTIS, M., MOUTSOPOULOS, H. M., TZIOUFAS, A. G., DOTSIKA, E. N.

“…Summary Immunotherapies against autoimmune diseases have been of limited success. Preventive vaccines could be developed on the basis to abrogate unwanted…”
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The value of synthetic linear epitope analogues of La/SSB for the detection of autoantibodies to La/SSB; specificity, sensitivity and comparison of methods by YIANNAKI, E. E, TZIOUFAS, A. G, BACHMANN, M, HANTOUMI, J, TSIKARIS, V, SAKARELLOS-DAITSIOTIS, M, SAKARELLOS, C, MOUTSOPOULOS, H. M

“…In a previous study it was shown that La/SSB contains four linear epitopes, p147–154, p291–302, p301–318 and p349–364. The aim of the present study was to…”
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Fine specificity of autoantibodies to La/SSB: epitope mapping, and characterization by TZIOUFAS, A. G., YIANNAKI, E., SAKARELLOS‐DAITSIOTIS, M., ROUTSIAS, J. G., SAKARELLOS, C., MOUTSOPOULOS, H. M.

“…The B cell epitope mapping of La/SSB was performed using 20 mer synthetic peptides overlapping by eight amino acids covering the whole sequence of the protein…”
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Study of antibody and T cell responses in rabbits immunized with synthetic human B cell epitope analogues of La (SSB) autoantigen by Yiannaki, E., Vlachoyiannopoulos, P. G., Manoussakis, M. N., Sakarellos, C., Sakarellos‐Daitsiotis, M., Moutsopoulos, H. M., Tzioufas, A. G.

“…The aim of this study was to investigate the immunogenicity of four synthetic peptides, representing linear B cell epitopes of the human La/SSB autoantigen:…”
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A three-residue cyclic scaffold of non-RGD containing peptide analogues as platelet aggregation inhibitors: Design, synthesis, and structure-function relationships by Stavrakoudis, Athanassios, Bizos, George, Eleftheriadis, Damianos, Kouki, Aggeliki, Panou-Pomonis, Eugenia, Sakarellos-Daitsiotis, Maria, Sakarellos, Constantinos, Tsoukatos, Demokritos, Tsikaris, Vassilios

“…Antagonists of fibrinogen at the GPIIb/IIIa receptor, which is the most abundant membrane protein on the platelet surface, are under active investigation as…”
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The Ser-Arg-Tyr-Asp region of the major surface glycoprotein of Leishmania mimics the Arg-Gly-Asp-Ser cell attachment region of fibronectin by SOTERIADOU, K. P, REMOUNDOS, M. S, KATSIKAS, M. C, TZINIA, A. K, TSIKARIS, V, SAKARELLOS, C, TZARTOS, S. J

“…The major surface glycoprotein of Leishmania, gp63, a fibronectin-like molecule, plays a key role in parasite-macrophage interaction. Binding of gp63 to…”
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A crystal molecular conformation of leucine-enkephalin related to the morphine molecule by Aubry, A, Birlirakis, N, Sakarellos-Daitsiotis, M, Sakarellos, C, Marraud, M

“…Leucine-enkephalin (Try1-Gly2-Gly3-Phe4-Leu5) has been crystallized as a trihydrate from water solution. X-ray diffraction reveals a tightly folded molecular…”
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No Evidence of Epitope Spreading After Immunization with the Major Sm Epitope P-P-G-M-R-P-P Anchored to Sequential Oligopeptide Carriers (SOCs) by Vlachoyiannopoulos, P.G, Petrovas, C, Tzioufas, A.G, Alexopoulos, Ch, Tsikaris, V, Guialis, A, Nakopoulou, L, Sakarellos-Daitsiotis, M, Sakarellos, C, Davaris, P, Moutsopoulos, H.M

“…The sequence Pro-Pro-Gly-Meth-Arg-Pro-Pro (PPGMRPP) is the major B-cell epitope of the Sm autoantigen. The aim of the present study was to evaluate the immune…”
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Epitope mapping of the Ro/SSA60KD autoantigen reveals disease-specific antibody-binding profiles by Routsias, J G, Tzioufas, A G, Sakarellos-Daitsiotis, M, Sakarellos, C, Moutsopoulos, H M

“…Anti-Ro60KD autoantibodies are commonly found in sera from patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). In order to…”
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The third-dimensional structure of the complex between an Fv antibody fragment and an analogue of the main immunogenic region of the acetylcholine receptor: A combined two-dimensional NMR, homology, and molecular modeling approach by Kleinjung, Jens, Petit, Marie-Christine, Orlewski, Piotr, Mamalaki, Avgi, Tzartos, Socrates J., Tsikaris, Vassilios, Sakarellos-Daitsiotis, Maria, Sakarellos, Constantinos, Marraud, Michel, Cung, Manh-Thong

“…Binding of autoantibodies to the acetylcholine receptor (AChR) plays a major role in the autoimmune disease Myasthenia gravis (MG). In this paper, we propose a…”
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Structural, Molecular and Immunological Properties of Linear B‐Cell Epitopes of Ro60KD Autoantigen by Routsias, Sakarellos‐Daitsiotis, Tsikaris, Sakarellos, Moutsopoulos, Tzioufas

“…Antibodies to Ro60KD protein are found with high frequency in sera from patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS)…”
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Calreticulin synthetic peptide analogues: anti‐peptide antibodies in autoimmune rheumatic diseases by ROUTSIAS, J. G., TZIOUFAS, A. G., SAKARELLOS‐DAITSIOTIS, M., SAKARELLOS, C., MOUTSOPOULOS, H. M.

“…SUMMARY Autoantibodies in sera from patients with systemic lupus erythemalosus (SLE) and onchocerciasis recognize calreticulin (CaR). a calcium‐binding…”
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Multiple anchoring of myelopeptides on sequential oligopeptide carriers (SOCn): synthesis, conformation and studies in human leukemia cells by Keramisanou, D., Tsikaris, V., Sakarellos-Daitsiotis, M., Sakarellos, C., Mikhailova, A. A., Strelkov, L. A.

“…: Myelopeptides, MP‐6 (Val‐Asp‐Pro‐Pro) and MP‐4 (Phe‐Arg‐Pro‐Arg‐Ile‐Met‐Thr‐Pro), induce metabolic changes in human leukemia cells, HL‐60, characteristic of…”
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