Search Results - "SAKAGUCHI, MASAKIYO"

S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis by Sakaguchi, Masakiyo

“…Great progress has been made in imaging for cancer metastasis. Eisenblaetter et al. developed an innovative S100A8/A9-specific single photon emission computed…”
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NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions by Murata, Hitoshi, Takamatsu, Hitoshi, Liu, Sulai, Kataoka, Ken, Huh, Nam-Ho, Sakaguchi, Masakiyo

“…Mutations of the PTEN-induced putative kinase 1 (PINK1) gene are a cause of autosomal recessive forms of Parkinson's disease. Recent studies have revealed that…”
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c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration by Murata, Hitoshi, Khine, Cho Cho, Nishikawa, Akane, Yamamoto, Ken-ichi, Kinoshita, Rie, Sakaguchi, Masakiyo

“…Mitochondrial dysfunction is a key pathological feature of many different types of neurodegenerative disease. Sterile alpha and Toll/interleukin receptor…”
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Histidine-Rich Glycoprotein Stimulates Human Neutrophil Phagocytosis and Prolongs Survival through CLEC1A by Takahashi, Yohei, Wake, Hidenori, Sakaguchi, Masakiyo, Yoshii, Yukinori, Teshigawara, Kiyoshi, Wang, Dengli, Nishibori, Masahiro

“…Histidine-rich glycoprotein (HRG) is a multifunctional plasma protein and maintains the homeostasis of blood cells and vascular endothelial cells. In the…”
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S100 Soil Sensor Receptors and Molecular Targeting Therapy Against Them in Cancer Metastasis by Tomonobu, Nahoko, Kinoshita, Rie, Sakaguchi, Masakiyo

“…The molecular mechanisms underlying the ‘seed and soil’ theory are unknown. S100A8/A9 (a heterodimer complex of S100A8 and S100A9 proteins that exhibits a…”
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Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR‐TKIs in non‐small cell lung cancer by Sato, Hiroki, Yamamoto, Hiromasa, Sakaguchi, Masakiyo, Shien, Kazuhiko, Tomida, Shuta, Shien, Tadahiko, Ikeda, Hirokuni, Hatono, Minami, Torigoe, Hidejiro, Namba, Kei, Yoshioka, Takahiro, Kurihara, Eisuke, Ogoshi, Yusuke, Takahashi, Yuta, Soh, Junichi, Toyooka, Shinichi

“…Compensatory activation of the signal transduction pathways is one of the major obstacles for the targeted therapy of non‐small cell lung cancer (NSCLC)…”
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SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes by Wang, Tianyi, Gao, Tong, Fujisawa, Masayoshi, Ohara, Toshiaki, Sakaguchi, Masakiyo, Yoshimura, Teizo, Matsukawa, Akihiro

“…Sprouty-related enabled/vasodilator-stimulated phosphoprotein homology 1 domain containing 2 (SPRED2) is an inhibitor of the mitogen-activated protein kinase…”
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PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice by Kasano-Camones, Carlos Ichiro, Takizawa, Masayuki, Ohshima, Noriyasu, Saito, Chinatsu, Iwasaki, Wakana, Nakagawa, Yuko, Fujitani, Yoshio, Yoshida, Ryo, Saito, Yoshifumi, Izumi, Takashi, Terawaki, Shin-Ichi, Sakaguchi, Masakiyo, Gonzalez, Frank J, Inoue, Yusuke

“…HNF4α regulates various genes to maintain liver function. There have been reports linking HNF4α expression to the development of non-alcoholic fatty liver…”
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Antitumor effect of afatinib, as a human epidermal growth factor receptor 2‐targeted therapy, in lung cancers harboring HER2 oncogene alterations by Suzawa, Ken, Toyooka, Shinichi, Sakaguchi, Masakiyo, Morita, Mizuki, Yamamoto, Hiromasa, Tomida, Shuta, Ohtsuka, Tomoaki, Watanabe, Mototsugu, Hashida, Shinsuke, Maki, Yuho, Soh, Junichi, Asano, Hiroaki, Tsukuda, Kazunori, Miyoshi, Shinichiro

“…Human epidermal growth factor receptor 2 (HER2) is a member of the HER family of proteins containing four receptor tyrosine kinases. It plays an important role…”
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PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1 by Saito, Ken, Mitsui, Ayaka, Sumardika, I. Wayan, Yokoyama, Yusuke, Sakaguchi, Masakiyo, Kondo, Eisaku

“…We previously reported that high expression of procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2) leads to stabilization and plasma membrane…”
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TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding by Sakaguchi, Masakiyo, Murata, Hitoshi, Yamamoto, Ken-ichi, Ono, Tomoyuki, Sakaguchi, Yoshihiko, Motoyama, Akira, Hibino, Toshihiko, Kataoka, Ken, Huh, Nam-ho

“…The receptor for advanced glycation end products (RAGE) is thought to be involved in the pathogenesis of a broad range of inflammatory, degenerative and…”
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SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells by Gao, Tong, Yang, Xu, Fujisawa, Masayoshi, Ohara, Toshiaki, Wang, Tianyi, Tomonobu, Nahoko, Sakaguchi, Masakiyo, Yoshimura, Teizo, Matsukawa, Akihiro

“…The downregulation of SPRED2, a negative regulator of the ERK1/2 pathway, was previously detected in human cancers; however, the biological consequence remains…”
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Novel Germline Mutation in the Transmembrane Domain of HER2 in Familial Lung Adenocarcinomas by YAMAMOTO, Hiromasa, HIGASA, Koichiro, MATSUO, Keitaro, KIURA, Katsuyuki, MIYOSHI, Shinichiro, MATSUDA, Fumihiko, TOYOOKA, Shinichi, SAKAGUCHI, Masakiyo, SHIEN, Kazuhiko, SOH, Junichi, ICHIMURA, Koichi, FURUKAWA, Masashi, HASHIDA, Shinsuke, TSUKUDA, Kazunori, TAKIGAWA, Nagio

“…We encountered a family of Japanese descent in which multiple members developed lung cancer. Using whole-exome sequencing, we identified a novel germline…”
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SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria by Murata, Hitoshi, Sakaguchi, Masakiyo, Kataoka, Ken, Huh, Nam-Ho

“…Mutations in PTEN-induced putative kinase 1 (PINK1) or parkin cause autosomal recessive forms of Parkinson's disease. Recent work suggests that loss of…”
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The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis by Araki, Kota, Kinoshita, Rie, Tomonobu, Nahoko, Gohara, Yuma, Tomida, Shuta, Takahashi, Yuta, Senoo, Satoru, Taniguchi, Akihiko, Itano, Junko, Yamamoto, Ken-ichi, Murata, Hitoshi, Suzawa, Ken, Shien, Kazuhiko, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Ichimura, Kouichi, Nishibori, Masahiro, Miyahara, Nobuaki, Toyooka, Shinichi, Sakaguchi, Masakiyo

“…In patients with interstitial pneumonia, pulmonary fibrosis is an irreversible condition that can cause respiratory failure. Novel treatments for pulmonary…”
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Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer by Li, Chunning, Yoshimura, Teizo, Tian, Miao, Wang, Yuze, Kondo, Takamasa, Yamamoto, Ken-Ichi, Fujisawa, Masayoshi, Ohara, Toshiaki, Sakaguchi, Masakiyo, Matsukawa, Akihiro

“…Background Patients with triple-negative breast cancer (TNBC) often have poorer prognosis than those with other subtypes because of its aggressive behaviors…”
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exMCAM-Fc, an S100A8/A9-mediated-metastasis blocker, efficiently reduced the number of circulating tumor cells that appeared in the blood flow by Tomonobu, Nahoko, Kinoshita, Rie, Sakaguchi, Masakiyo

“…Metastasis is the major cause of treatment failure in cancer patients and of cancer-associated death so that therapeutic regulation of metastasis is very…”
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PODXL1 promotes metastasis of the pancreatic ductal adenocarcinoma by activating the C5aR/C5a axis from the tumor microenvironment by Saito, Ken, Iioka, Hidekazu, Maruyama, Satoshi, Sumardika, I. Wayan, Sakaguchi, Masakiyo, Kondo, Eisaku

“…Pancreatic invasive ductal adenocarcinoma (PDAC) is a representative intractable malignancy under the current cancer therapies, and is considered a scirrhous…”
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Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration by Murata, Hitoshi, Phoo, May Tha Zin, Ochi, Toshiki, Tomonobu, Nahoko, Yamamoto, Ken-ichi, Kinoshita, Rie, Miyazaki, Ikuko, Nishibori, Masahiro, Asanuma, Masato, Sakaguchi, Masakiyo

“…Abstract Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) is a NAD+ hydrolase that plays a key role in axonal degeneration and…”
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Inhibiting S100A8/A9 attenuates airway obstruction in a mouse model of heterotopic tracheal transplantation by Shimizu, Dai, Okazaki, Mikio, Sugimoto, Seiichiro, Kinoshita, Rie, Nakata, Kentaro, Tanaka, Shin, Hashimoto, Kohei, Miyoshi, Kentaroh, Yamane, Masaomi, Matsukawa, Akihiro, Sakaguchi, Masakiyo, Toyooka, Shinichi

“…Although bronchiolitis obliterans syndrome (BOS) is a major cause of death after lung transplantation, an effective drug therapy for BOS has not yet developed…”
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