Search Results - "SAJAN, M. P"

TQM implementation practices and performance outcome of Indian hospitals: exploratory findings by Puthanveettil, Biju Augustine, Vijayan, Shilpa, Raj, Anil, MP, Sajan

“…PurposeThis paper explores and interprets the linkage between total quality management (TQM) practices and organizational performance measures for improving…”
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Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors by Sajan, M. P., Farese, R. V.

“…Aims/hypothesis We examined the role of protein kinase C-ι (PKC-ι) in mediating alterations in the abundance of enzymes in hepatocytes of type 2 diabetic…”
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AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC by Sajan, M P, Bandyopadhyay, G, Miura, A, Standaert, M L, Nimal, S, Longnus, S L, Van Obberghen, E, Hainault, I, Foufelle, F, Kahn, R, Braun, U, Leitges, M, Farese, R V

“…Activators of 5'-AMP-activated protein kinase (AMPK) 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), metformin, and exercise activate atypical…”
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Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance by Sajan, M. P, Standaert, M. L, Rivas, J, Miura, A, Kanoh, Y, Soto, J, Taniguchi, C. M, Kahn, C. R, Farese, R. V

“…Aims/hypothesis Previous findings in rodents used as a model of diabetes suggest that insulin activation of atypical protein kinase C (aPKC) is impaired in…”
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Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO₄)₃ in muscle of diabetic subjects by Luna, V, Casauban, L, Sajan, M. P, Gomez-Daspet, J, Powe, J. L, Miura, A, Rivas, J, Standaert, M. L, Farese, R. V

“…Aims/hypothesis Metformin is widely used for treating type 2 diabetes mellitus, but its actions are poorly understood. In addition to diminishing hepatic…”
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Lean manufacturing practices in Indian manufacturing SMEs and their effect on sustainability performance by M.P, Sajan, P.R, Shalij, A, Ramesh, P, Biju Augustine

“…Purpose The relevance of small and medium enterprises (SMEs) in contributing to the economy and social development is increasingly felt in the current business…”
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Atypical protein kinase C in insulin action and insulin resistance by Farese, R V, Sajan, M P, Standaert, M L

“…It now seems clear that aPKC (atypical protein kinase C) isoforms are required for insulin-stimulated glucose transport in muscle and adipocytes. Moreover,…”
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Insulin signalling downstream of protein kinase B is potentiated by 5′AMP-activated protein kinase in rat hearts in vivo by Longnus, S. L., Ségalen, C., Giudicelli, J., Sajan, M. P., Farese, R. V., Van Obberghen, E.

“…5'AMP-activated protein kinase (AMPK) and insulin stimulate glucose transport in heart and muscle. AMPK acts in an additive manner with insulin to increase…”
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Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle by Temofonte, N, Sajan, M. P, Nimal, S, Pastoor, T, Fumero, C, Casaubon, L, Powe, J. L, Standaert, M. L, Farese, R. V

“…Aims/hypotheses Insulin-stimulated glucose transport in muscle is impaired in type 2 diabetes, presumably reflecting reduced activation of atypical protein…”
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A multicase study approach in Indian manufacturing SMEs to investigate the effect of Lean manufacturing practices on sustainability performance by M.P, Sajan, P.R, Shalij

“…Purpose The purpose of this study is to investigate whether the adoption of Lean manufacturing (LM) contributes towards the sustainability performance of small…”
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Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans by CASAUBON, L, SAJAN, M. P, RIVAS, J, POWE, J. L, STANDAERT, M. L, FARESE, R. V

“…Insulin-stimulated glucose transport in muscle is impaired in obesity and type 2 diabetes, but alterations in levels of relevant signalling factors, i.e…”
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Dependence of Insulin-Stimulated Glucose Transporter 4 Translocation on 3-Phosphoinositide-Dependent Protein Kinase-1 and Its Target Threonine-410 in the Activation Loop of Protein Kinase C-ζ by Bandyopadhyay, G, Standaert, M. L, Sajan, M. P, Karnitz, L. M, Cong, L, Quon, M. J, Farese, R. V

“…Previous studies have suggested that 1) atypical protein kinase C (PKC) isoforms are required for insulin stimulation of glucose transport, and 2)…”
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Cortical excitability in drug naive juvenile myoclonic epilepsy by Puri, Vinod, Sajan, P.M, Chowdhury, Veena, Chaudhry, Neera

“…Abstract Purpose To evaluate the effect of diurnal variability on cortical excitability using single pulse transcranial magnetic stimulation (TMS), in drug…”
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Protein Kinase C-ζ and Phosphoinositide-dependent Protein Kinase-1 Are Required for Insulin-induced Activation of ERK in Rat Adipocytes by Sajan, Mini P., Standaert, Mary L., Bandyopadhyay, Gautam, Quon, Michael J., Burke, Terrence R., Farese, Robert V.

“…The mechanisms used by insulin to activate the multifunctional intracellular effectors, extracellular signal-regulated kinases 1 and 2 (ERK1/2), are only…”
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Impaired Activation of Protein Kinase C-ζ by Insulin and Phosphatidylinositol-3,4,5-(PO4)3 in Cultured Preadipocyte-Derived Adipocytes and Myotubes of Obese Subjects by Sajan, M. P., Standaert, M. L., Miura, A., Bandyopadhyay, G., Vollenweider, P., Franklin, D. M., Lea-Currie, R., Farese, R. V.

“…Insulin resistance in obesity is partly due to diminished glucose transport in myocytes and adipocytes, but underlying mechanisms are uncertain…”
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Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport by Standaert, M L, Bandyopadhyay, G, Sajan, M P, Cong, L, Quon, M J, Farese, R V

“…Okadaic acid, an inhibitor of protein phosphatases 1 and 2A, is known to provoke insulin-like effects on GLUT4 translocation and glucose transport, but the…”
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Insulin and PIP3 Activate PKC-ζ by Mechanisms That Are Both Dependent and Independent of Phosphorylation of Activation Loop (T410) and Autophosphorylation (T560) Sites by Standaert, Mary L, Bandyopadhyay, Gautam, Kanoh, Yoshinori, Sajan, Mini P, Farese, Robert V

“…Activation of protein kinase C-ζ (PKC-ζ) by insulin requires phosphatidylinositol (PI) 3-kinase-dependent increases in phosphatidylinositol-3,4,5-(PO4)3 (PIP3)…”
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Activation of the ERK Pathway and Atypical Protein Kinase C Isoforms in Exercise- and Aminoimidazole-4-carboxamide- 1-β-d-riboside (AICAR)-stimulated Glucose Transport by Chen, Hubert C., Bandyopadhyay, Gautam, Sajan, Mini P., Kanoh, Yoshinori, Standaert, Mary, Farese, Robert V., Farese, Robert V.

“…Exercise increases glucose transport in muscle by activating 5′-AMP-activated protein kinase (AMPK), but subsequent events are unclear. Presently, we examined…”
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Insulin Activates Protein Kinases C-ζ and C-λ by an Autophosphorylation-dependent Mechanism and Stimulates Their Translocation to GLUT4 Vesicles and Other Membrane Fractions in Rat Adipocytes by Standaert, Mary L., Bandyopadhyay, Gautam, Perez, Liliam, Price, Debbie, Galloway, Lamar, Poklepovic, Andrew, Sajan, Minni P., Cenni, Vitorria, Sirri, Alessandra, Moscat, Jorge, Toker, Alex, Farese, Robert V.

“…In rat adipocytes, insulin provoked rapid increases in (a) endogenous immunoprecipitable combined protein kinase C (PKC)-ζ/λ activity in plasma membranes and…”
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Activity of some respiratory enzymes and cytochrome contents in rat hepatic mitochondria following aflatoxin B1 administration by SAJAN, M. P, SATAV, J. G, BHATTACHARYA, R. K

“…Effects of aflatoxin B1 (AFB1) administration (7 mg/kg body weight, i.p.) on rat hepatic mitochondrial respiratory components have been examined. Succinoxidase…”
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