Search Results - "SAITO, Hidehiko"

Unrecognized blood clotting factors by Saito, Hidehiko, Kojima, Tetsuhito

“…Most clotting factors were initially discovered as agents functionally deficient in the plasmas of rare patients with hereditary coagulation disorders. During…”
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Advances in the understanding of MYH9 disorders by Kunishima, Shinji, Saito, Hidehiko

“…PURPOSE OF REVIEWMYH9 disorders are autosomal dominant macrothrombocytopenias with leukocyte inclusion bodies caused by mutations in MYH9, the gene for the…”
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ACTN1 Mutations Cause Congenital Macrothrombocytopenia by Kunishima, Shinji, Okuno, Yusuke, Yoshida, Kenichi, Shiraishi, Yuichi, Sanada, Masashi, Muramatsu, Hideki, Chiba, Kenichi, Tanaka, Hiroko, Miyazaki, Koji, Sakai, Michio, Ohtake, Masatoshi, Kobayashi, Ryoji, Iguchi, Akihiro, Niimi, Gen, Otsu, Makoto, Takahashi, Yoshiyuki, Miyano, Satoru, Saito, Hidehiko, Kojima, Seiji, Ogawa, Seishi

“…Congenital macrothrombocytopenia (CMTP) is a heterogeneous group of rare platelet disorders characterized by a congenital reduction of platelet counts and…”
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TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia by Kunishima, Shinji, Nishimura, Satoshi, Suzuki, Hidenori, Imaizumi, Masue, Saito, Hidehiko

“…This report describes a family with TUBB1‐associated macrothrombocytopenia diagnosed based on abnormal platelet β1‐tubulin distribution. A circumferential…”
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Brief history of the Asiatic International Society of Hematology: our roots of international cooperation with Asian countries by Saito, Hidehiko, Hotta, Tomomitsu, Naoe, Tomoki

“…This year, 2018, marks the 60th anniversary of the Asiatic International Society of Hematology founded in 1958 and it seems to be a fitting occasion on which…”
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Thrombosis from a Prothrombin Mutation Conveying Antithrombin Resistance by Miyawaki, Yuhri, Suzuki, Atsuo, Fujita, Junko, Maki, Asuka, Okuyama, Eriko, Murata, Moe, Takagi, Akira, Murate, Takashi, Kunishima, Shinji, Sakai, Michio, Okamoto, Kohji, Matsushita, Tadashi, Naoe, Tomoki, Saito, Hidehiko, Kojima, Tetsuhito

“…Thrombophilias are usually caused by loss-of-function mutations in natural anticoagulants or gain-of-function mutations in procoagulants. A mutation in a…”
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The Japan Marrow Donor Program, 25 years of experience in achieving 20,000 bone marrow transplantations: organization structure, activity, and financial basis by Saito, Hidehiko, Ito, Masaharu, Kato, Shunichi, Kodera, Yoshihisa, Okamoto, Shinichiro, Taniguchi, Shuichi, Takanashi, Minoko, Kanamori, Heiwa, Masaoka, Toru, Takaku, Fumimaro

“…The Japan Marrow Donor Program (JMDP), established in 1991, has continued to grow in its capacity to facilitate unrelated bone marrow (BMT) and peripheral…”
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Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain by KIYOI, Hitoshi, OHNO, Ryuzo, UEDA, Ryuzo, SAITO, Hidehiko, NAOE, Tomoki

“…Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly…”
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Myh9 R702C is associated with erythroid abnormality with splenomegaly in mice by Kanematsu, Takeshi, Suzuki, Nobuaki, Tamura, Shogo, Suzuki, Atsuo, Ishikawa, Yuichi, Katsumi, Akira, Kiyoi, Hitoshi, Saito, Hidehiko, Kunishima, Shinji, Kojima, Tetsuhito, Matsushita, Tadashi

“…MYH9 disorders are characterized by giant platelets, thrombocytopenia, and Döhle body-like cytoplasmic inclusion bodies in granulocytes. However, whether these…”
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Recombinant human soluble thrombomodulin (thrombomodulin alfa) to treat disseminated intravascular coagulation in solid tumors: results of a one-arm prospective trial by Tamura, Kazuo, Saito, Hidehiko, Asakura, Hidesaku, Okamoto, Kohji, Tagawa, Jun, Hayakawa, Toru, Aoki, Nobuo

“…Background Disseminated intravascular coagulation (DIC) associated with solid tumors (DIC-ST) is often encountered in clinical practice. Patients with DIC-ST…”
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Somatic mosaicism in MYH9 disorders: the need to carefully evaluate apparently healthy parents by Kunishima, Shinji, Kitamura, Katsumasa, Matsumoto, Tae, Sekine, Takashi, Saito, Hidehiko

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Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders by Kunishima, Shinji, Hamaguchi, Motohiro, Saito, Hidehiko

“…MYH9 disorders such as May-Hegglin anomaly are characterized by macrothrombocytopenia and cytoplasmic granulocyte inclusion bodies that result from mutations…”
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Historical hematology: May–Hegglin anomaly by Saito, Hidehiko, Kunishima, Shinji

“…May–Hegglin anomaly is a rare autosomal dominant platelet disorder characterized by thrombocytopenia, giant platelets, and unique leukocyte inclusion bodies…”
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Combined medialis pedis and medial plantar fasciocutaneous flaps for coverage of soft tissue defects of multiple adjacent fingers by Okada, Mitsuhiro, Saito, Hidehiko, Kazuki, Kenichi, Nakamura, Hiroaki

“…Soft tissue defects of adjacent multiple fingers covered by a single large flap require secondary separation of the flap into each finger. Such covering…”
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A historical glance at hemophilia by Saito, Hidehiko

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Molecular mechanisms of syndecan-4 upregulation by TNF-α in the endothelium-like EAhy926 cells by Okuyama, Eriko, Suzuki, Atsuo, Murata, Moe, Ando, Yumi, Kato, Io, Takagi, Yuki, Takagi, Akira, Murate, Takashi, Saito, Hidehiko, Kojima, Tetsuhito

“…Syndecan-4, a cell-surface heparan sulfate proteoglycan, can participate in inflammation and wound healing as a host defense molecule. Tumour necrosis factor…”
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Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability by Suzuki, Nobuaki, Kunishima, Shinji, Ikejiri, Makoto, Maruyama, Shoichi, Sone, Michihiko, Takagi, Akira, Ikawa, Masahito, Okabe, Masaru, Kojima, Tetsuhito, Saito, Hidehiko, Naoe, Tomoki, Matsushita, Tadashi

“…Nonmuscle myosin heavy chain IIA (NMMHCIIA) encoded by MYH9 is associated with autosomal dominantly inherited diseases called MYH9 disorders. MYH9 disorders…”
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Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines by HAYAKAWA, F, TOWATARI, M, KIYOI, H, TANIMOTO, M, KITAMURA, T, SAITO, H, NAOE, T

“…We have recently identified an internal tandem duplication of the human Flt3 gene in approximately 20% of acute myeloid leukemia (AML) cases. In the present…”
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Bernard-Soulier syndrome caused by a hemizygous GPIbβ mutation and 22q11.2 deletion by Kunishima, Shinji, Imai, Tsuyoshi, Kobayashi, Ryoji, Kato, Motohiro, Ogawa, Seishi, Saito, Hidehiko

“…Background Bernard–Soulier syndrome (BSS) is a rare autosomal recessive bleeding disorder characterized by giant platelets, thrombocytopenia, and a prolonged…”
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Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial by Ito, Takashi, Maruyama, Ikuro, Shimazaki, Shuji, Yamamoto, Yasuhiro, Aikawa, Naoki, Hirayama, Akio, Honda, Goichi, Saito, Hidehiko

“…The efficacy and safety of thrombomodulin alfa (TM‐α), a cofactor protein promoting thrombin‐mediated protein C activation, have been examined in a phase 3…”
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