Search Results - "SAITO, Atsuhiro"

Feasibility, Safety, and Therapeutic Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets in a Porcine Ischemic Cardiomyopathy Model by KAWAMURA, Masashi, MIYAGAWA, Shigeru, OKANO, Teruo, SAWA, Yoshiki, MIKI, Kenji, SAITO, Atsuhiro, FUKUSHIMA, Satsuki, HIGUCHI, Takahiro, KAWAMURA, Takuji, KURATANI, Toru, DAIMON, Takashi, SHIMIZU, Tatsuya

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are a promising source of cells for regenerating myocardium. However, several issues,…”
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Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case by Sawa, Yoshiki, Miyagawa, Shigeru, Sakaguchi, Taichi, Fujita, Tomoyuki, Matsuyama, Akifumi, Saito, Atsuhiro, Shimizu, Tatsuya, Okano, Teruo

“…Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently,…”
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Transplantation of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Is Superior to Somatic Stem Cell Therapy for Restoring Cardiac Function and Oxygen Consumption in a Porcine Model of Myocardial Infarction by Ishida, Masaru, Miyagawa, Shigeru, Saito, Atsuhiro, Fukushima, Satsuki, Harada, Akima, Ito, Emiko, Ohashi, Fumiya, Watabe, Tadashi, Hatazawa, Jun, Matsuura, Katsuhisa, Sawa, Yoshiki

“…BACKGROUNDSomatic stem cell (SC) therapy can improve cardiac performance following ischemic injury. In this study, we investigated whether induced pluripotent…”
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Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model by Kawamura, Masashi, Miyagawa, Shigeru, Fukushima, Satsuki, Saito, Atsuhiro, Miki, Kenji, Funakoshi, Shunsuke, Yoshida, Yoshinori, Yamanaka, Shinya, Shimizu, Tatsuya, Okano, Teruo, Daimon, Takashi, Toda, Koichi, Sawa, Yoshiki

“…Transplant of human induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) cell-sheet is a promising approach for treating ischemic cardiomyopathy…”
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Fabrication of natto-structured oxides using metal-EDTA solution by Saito, Atsuhiro, Komatsu, Keiji, Nakamura, Atsushi, Saitoh, Hidetoshi

“…We fabricated unique ceramics matrix composites (CMCs) called natto-structured oxides using metal-ethylenediaminetetraacetic acid (EDTA) solution. The…”
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Phase I Clinical Trial of Autologous Stem Cell-Sheet Transplantation Therapy for Treating Cardiomyopathy by Miyagawa, Shigeru, Domae, Keitaro, Yoshikawa, Yasushi, Fukushima, Satsuki, Nakamura, Teruya, Saito, Atsuhiro, Sakata, Yasushi, Hamada, Seiki, Toda, Koichi, Pak, Kyongsun, Takeuchi, Masahiro, Sawa, Yoshiki

“…When transplanted into failing heart, autologous somatic tissue-derived cells yield functional recovery via paracrine effects that enhance native regeneration…”
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Intratumoral injection of hemagglutinating virus of Japan-envelope vector yielded an antitumor effect for advanced melanoma: a phase I/IIa clinical study by Kiyohara, Eiji, Tanemura, Atsushi, Nishioka, Megumi, Yamada, Mizuho, Tanaka, Aya, Yokomi, Akinori, Saito, Atsuhiro, Sakura, Kazuma, Nakajima, Toshihiro, Myoui, Akira, Sakurai, Toshiharu, Kawakami, Yutaka, Kaneda, Yasufumi, Katayama, Ichiro

“…Hemagglutinating virus of Japan (HVJ; Sendai virus) is an RNA virus that has cell fusion activity. HVJ-envelope (HVJ-E) is a UV-irradiated HVJ particle that…”
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Myocardial regenerative therapy using a scaffold-free skeletal-muscle-derived cell sheet in patients with dilated cardiomyopathy even under a left ventricular assist device: a safety and feasibility study by Yoshikawa, Yasushi, Miyagawa, Shigeru, Toda, Koichi, Saito, Atsuhiro, Sakata, Yasushi, Sawa, Yoshiki

“…Background and purpose Despite promising experimental results, clinically, intramyocardial myoblast injection failed to reverse remodeling and it induced…”
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A novel model of chronic limb ischemia to therapeutically evaluate the angiogenic effects of drug candidates by Shimatani, Kenichiro, Sato, Hiromu, Saito, Atsuhiro, Sasai, Masao, Watanabe, Kenichi, Mizukami, Kazuhiko, Kamohara, Masazumi, Miyagawa, Shigeru, Sawa, Yoshiki

“…Critical limb ischemia (CLI) is a severe state of peripheral artery disease with high unmet clinical needs. Further, there are no effective treatment options…”
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Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells by Takeda, Maki, Miyagawa, Shigeru, Fukushima, Satsuki, Saito, Atsuhiro, Ito, Emiko, Harada, Akima, Matsuura, Ryohei, Iseoka, Hiroko, Sougawa, Nagako, Mochizuki-Oda, Noriko, Matsusaki, Michiya, Akashi, Mitsuru, Sawa, Yoshiki

“…An in vitro drug-induced cardiotoxicity assay is a critical step in drug discovery for clinical use. The use of human induced pluripotent stem cell-derived…”
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Pivotal Role of Non-cardiomyocytes in Electromechanical and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissue by Iseoka, Hiroko, Miyagawa, Shigeru, Fukushima, Satsuki, Saito, Atsuhiro, Masuda, Shigeo, Yajima, Shin, Ito, Emiko, Sougawa, Nagako, Takeda, Maki, Harada, Akima, Lee, Jong-Kook, Sawa, Yoshiki

“…Although engineered cardiac tissues (ECTs) derived from induced pluripotent stem cells (iPSCs) are promising for myocardial regenerative therapy, the…”
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Immunologic targeting of CD30 eliminates tumourigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy by Sougawa, Nagako, Miyagawa, Shigeru, Fukushima, Satsuki, Kawamura, Ai, Yokoyama, Junya, Ito, Emiko, Harada, Akima, Okimoto, Kaori, Mochizuki-Oda, Noriko, Saito, Atsuhiro, Sawa, Yoshiki

“…Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating…”
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CXCL4/PF4 is a predictive biomarker of cardiac differentiation potential of human induced pluripotent stem cells by Ohashi, Fumiya, Miyagawa, Shigeru, Yasuda, Satoshi, Miura, Takumi, Kuroda, Takuya, Itoh, Masayoshi, Kawaji, Hideya, Ito, Emiko, Yoshida, Shohei, Saito, Atsuhiro, Sameshima, Tadashi, Kawai, Jun, Sawa, Yoshiki, Sato, Yoji

“…Selection of human induced pluripotent stem cell (hiPSC) lines with high cardiac differentiation potential is important for regenerative therapy and drug…”
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Role and therapeutic effects of skeletal muscle-derived non-myogenic cells in a rat myocardial infarction model by Iseoka, Hiroko, Miyagawa, Shigeru, Saito, Atsuhiro, Harada, Akima, Sawa, Yoshiki

“…Transplantation of skeletal myoblast sheets is a promising strategy for the treatment of heart failure, and its therapeutic effects have already been proven in…”
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Basic points to consider regarding the preparation of extracellular vesicles and their clinical applications in Japan by Tsuchiya, Atsunori, Terai, Shuji, Horiguchi, Ikki, Homma, Yasuhiro, Saito, Atsuhiro, Nakamura, Norimasa, Sato, Yoji, Ochiya, Takahiro, Kino-oka, Masahiro

“…In recent years, extracellular vesicles (EVs)11Extracellular vesicles; the positioning paper of the International Society of Extracellular Vesicles (ISEV)…”
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Layered implantation of myoblast sheets attenuates adverse cardiac remodeling of the infarcted heart by Sekiya, Naosumi, MD, Matsumiya, Goro, MD, PhD, Miyagawa, Shigeru, MD, PhD, Saito, Atsuhiro, PhD, Shimizu, Tatsuya, MD, PhD, Okano, Teruo, PhD, Kawaguchi, Naomasa, PhD, Matsuura, Nariaki, MD, PhD, Sawa, Yoshiki, MD, PhD

“…Objective We previously showed that autologous myoblast sheets constructed with tissue-engineering techniques improved the function of the impaired heart. In…”
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SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis by Uchinaka, Ayako, Hamada, Yoshinosuke, Mori, Seiji, Miyagawa, Shigeru, Saito, Atsuhiro, Sawa, Yoshiki, Matsuura, Nariaki, Yamamoto, Hirofumi, Kawaguchi, Naomasa

“…Osteopontin (OPN) is involved in various physiological processes such as inflammatory and wound healing. However, little is known about the effects of OPN on…”
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Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats by Kainuma, Satoshi, Miyagawa, Shigeru, Fukushima, Satsuki, Tsuchimochi, Hirotsugu, Sonobe, Takashi, Fujii, Yutaka, Pearson, James T, Saito, Atsuhiro, Harada, Akima, Toda, Koichi, Shirai, Mikiyasu, Sawa, Yoshiki

“…It has been shown that the size of myocardial infarction in rats created by coronary ligation technique is not uniform, varying from 4% to 65%. We hypothesized…”
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Enhanced Pulmonary Vascular and Alveolar Development via Prenatal Administration of a Slow-Release Synthetic Prostacyclin Agonist in Rat Fetal Lung Hypoplasia by Umeda, Satoshi, Miyagawa, Shigeru, Fukushima, Satsuki, Oda, Noriko, Saito, Atsuhiro, Sakai, Yoshiki, Sawa, Yoshiki, Okuyama, Hiroomi

“…Lung hypoplasia and pulmonary hypertension are the major causes of mortality in neonates with congenital diaphragmatic hernia (CDH). Although the prostaglandin…”
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Development of a vitrification method for preserving human myoblast cell sheets for myocardial regeneration therapy by Ohkawara, Hirotatsu, Miyagawa, Shigeru, Fukushima, Satsuki, Yajima, Shin, Saito, Atsuhiro, Nagashima, Hiroshi, Sawa, Yoshiki

“…Tissue-engineered cardiac constructs have potential in the functional recovery of heart failure; however, the preservation of these constructs is crucial for…”
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