Search Results - "SAHOTA, Surinder S"

Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma by Tete, Sarah M, Bijl, Marc, Sahota, Surinder S, Bos, Nicolaas A

“…The plasma cell proliferative disorders monoclonal gammopathy of undetermined significance (MGUS) and malignant multiple myeloma (MM) are characterized by an…”
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Exome Sequencing in Classic Hairy Cell Leukaemia Reveals Widespread Variation in Acquired Somatic Mutations between Individual Tumours Apart from the Signature BRAF V(600)E Lesion by Weston-Bell, Nicola J, Tapper, Will, Gibson, Jane, Bryant, Dean, Moreno, Yurany, John, Melford, Ennis, Sarah, Kluin-Nelemans, Hanneke C, Collins, Andrew R, Sahota, Surinder S

“…In classic Hairy cell leukaemia (HCLc), a single case has thus far been interrogated by whole exome sequencing (WES) in a treatment naive patient, in which…”
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Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines by BABBAGE, Gavin, OTTENSMEIER, Christian H, BLAYDES, Jeremy, STEVENSON, Freda K, SAHOTA, Surinder S

“…When cells transform, phenotypic and genetic profiles can be dramatically altered. Nevertheless, a recent report identifying IgG in breast cancer cells was…”
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Cancer testis antigens in newly diagnosed and relapse multiple myeloma: prognostic markers and potential targets for immunotherapy by VAN DUIN, Mark, BROYL, Annemiek, SAHOTA, Surinder S, SONNEVELD, Pieter, DE KNEGT, Yvonne, GOLDSCHMIDT, Hartmut, RICHARDSON, Paul G, HOP, Wim C. J, VAN DER HOLT, Bronno, JOSEPH-PIETRAS, Debora, MULLIGAN, George, NEUWIRTH, Rachel

“…In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not…”
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Variant B cell receptor isotype functions differ in hairy cell leukemia with mutated BRAF and IGHV genes by Weston-Bell, Nicola J, Forconi, Francesco, Kluin-Nelemans, Hanneke C, Sahota, Surinder S

“…A functional B-cell receptor (BCR) is critical for survival of normal B-cells, but whether it plays a comparable role in B-cell malignancy is as yet not fully…”
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Induction of indoleamine-2,3 dioxygenase in bone marrow stromal cells inhibits myeloma cell growth by Pfeifer, Sabine, Schreder, Martin, Bolomsky, Arnold, Graffi, Sebastian, Fuchs, Dietmar, Sahota, Surinder S., Ludwig, Heinz, Zojer, Niklas

“…Purpose Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme with immunoregulatory properties in cancer. By focusing on multiple myeloma cells…”
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Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch by Forconi, Francesco, Sahota, Surinder S., Raspadori, Donatella, Ippoliti, Micaela, Babbage, Gavin, Lauria, Francesco, Stevenson, Freda K.

“…Hairy cell leukemia (HCL) commonly expresses multiple immunoglobulin isotypes, a feature rare in other B-cell malignancies or in normal B cells. In HCL, there…”
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Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia by Forconi, Francesco, Sozzi, Elisa, Rossi, Davide, Sahota, Surinder S, Amato, Teresa, Raspadori, Donatella, Trentin, Livio, Leoncini, Lorenzo, Gaidano, Gianluca, Lauria, Francesco

“…1 Sezione Ematologia e Trapianti, Università di Siena 2 Divisione di Ematologia, Dipartimento di Medicina Clinica e Sperimentale and Centro Interdisciplinare…”
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The genomic landscape and clonal evolutionary trajectory of classical hairy cell leukemia by Moreno Rueda, Luz Yurany, Bryant, Dean, Tapper, William J., Weston-Bell, Nicola J., Wedge, David C., Ansari-Pour, Naser, Sahota, Surinder S.

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Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma by Noble, Fergus, Mellows, Toby, McCormick Matthews, Leo H., Bateman, Adrian C., Harris, Scott, Underwood, Timothy J., Byrne, James P., Bailey, Ian S., Sharland, Donna M., Kelly, Jamie J., Primrose, John N., Sahota, Surinder S., Bateman, Andrew R., Thomas, Gareth J., Ottensmeier, Christian H.

“…Background Oesophageal adenocarcinoma (OAC) is increasingly common in the west, and survival remains poor at 10–15 % at 5 years. Immune responses are…”
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Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing by Forconi, Francesco, Sahota, Surinder S., Raspadori, Donatella, Mockridge, Christopher I., Lauria, Francesco, Stevenson, Freda K.

“…Hairy cell leukemia (HCL) derives from a mature B cell and expresses markers associated with activation. Analysis of immunoglobulin variable region genes has…”
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Tracking B-Cell Repertoires and Clonal Histories in Normal and Malignant Lymphocytes by Weston-Bell, Nicola J, Cowan, Graeme, Sahota, Surinder S

“…Methods for tracking B-cell repertoires and clonal history in normal and malignant B-cells based on immunoglobulin variable region (IGV) gene analysis have…”
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A VH4-34+ myeloma protein with weak autoreactivity by Froyland, Marianne, Thompson, Keith M, Thorpe, Susan J, Sahota, Surinder S, Gedde-Dahl, Tobias, Bogen, Bjarne

“…From the Institute of Immunology, University of Oslo and Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway (MF, KMT, BB); National Institute for…”
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Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma by Cowan, Graeme, Weston-Bell, Nicola J, Bryant, Dean, Seckinger, Anja, Hose, Dirk, Zojer, Niklas, Sahota, Surinder S

“…Human multiple myeloma (MM) is characterized by accumulation of malignant terminally differentiated plasma cells (PCs) in the bone marrow (BM), raising the…”
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Monoclonal paraprotein influences baseline B-cell repertoire diversity and perturbates influenza vaccination-induced B-cell response by Tete, Sarah M, Kipling, David, Westra, Johanna, de Haan, Aalzen, Bijl, Marc, Dunn-Walters, Deborah K, Sahota, Surinder S, Bos, Nicolaas A

“…Monoclonal gammopathy of undetermined significance (MGUS) arises from a clonal expansion of plasma cells in the bone marrow, secreting monoclonal (M)…”
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DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma by Stevenson, Freda K, King, Catherine A, Spellerberg, Myfanwy B, Zhu, Delin, Rice, Jason, Sahota, Surinder S, Thompsett, Andrew R, Hamblin, Terry J, Radl, Jiri

“…Vaccination with idiotypic protein protects against B-cell lymphoma, mainly through anti-idiotypic antibody. For use in patients, DNA vaccines containing…”
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Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events by Sahota, Surinder S., Forconi, Francesco, Ottensmeier, Christian H., Provan, Drew, Oscier, David G., Hamblin, Terry J., Stevenson, Freda K.

“…There exists a wide spectrum of IgM-secreting B-cell tumors with different clinical behavior. Knowledge of the VH gene status can reveal their origin and…”
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Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events by BABBAGE, Gavin, GARAND, Richard, ROBILLARD, Nelly, ZOJER, Niklas, STEVENSON, Freda K, SAHOTA, Surinder S

“…Isotype switch commonly follows onset of somatic hypermutation in the germinal center (GC), with activation-induced cytidine deaminase (AID) as a prerequisite…”
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Lack of allelic exclusion by secondary rearrangements of tumour B-cell receptor light chains in hairy cell leukaemia by Sozzi, Elisa, Amato, Teresa, Sahota, Surinder S., Nuti, Sandra, Raspadori, Donatella, Sicuranza, Anna, Cencini, Emanuele, Tosi, Piero, Lauria, Francesco, Forconi, Francesco

“…Analyses of the tumour immunoglobulin (Ig) gene (IG) heavy (H) and light chains show heterogeneity of mutational status, but reveal common features of ongoing…”
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PASD1 is a potential multiple myeloma–associated antigen by Sahota, Surinder S., Goonewardena, C. Madusha, Cooper, Christopher D.O., Liggins, Amanda P., Ait-Tahar, Kamal, Zojer, Niklas, Stevenson, Freda K., Banham, Alison H., Pulford, Karen

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