Search Results - "SAGARA, Takeshi"

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents by Hirai, Hiroshi, Iwasawa, Yoshikazu, Okada, Megumu, Arai, Tsuyoshi, Nishibata, Toshihide, Kobayashi, Makiko, Kimura, Toshifumi, Kaneko, Naoki, Ohtani, Junko, Yamanaka, Kazunori, Itadani, Hiraku, Takahashi-Suzuki, Ikuko, Fukasawa, Kazuhiro, Oki, Hiroko, Nambu, Tadahiro, Jiang, Jian, Sakai, Takumi, Arakawa, Hiroharu, Sakamoto, Toshihiro, Sagara, Takeshi, Yoshizumi, Takashi, Mizuarai, Shinji, Kotani, Hidehito

“…Wee1 is a tyrosine kinase that phosphorylates and inactivates CDC2 and is involved in G 2 checkpoint signaling. Because p53 is a key regulator in the G 1…”
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Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use by Ito, Satoru, Otsuki, Sachie, Ohsawa, Hirokazu, Hirano, Atsushi, Kazuno, Hideki, Yamashita, Satoshi, Egami, Kosuke, Shibata, Yoshihiro, Yamamiya, Ikuo, Yamashita, Fumiaki, Kodama, Yasuo, Funabashi, Kaoru, Kazuno, Hiromi, Komori, Toshiharu, Suzuki, Satoshi, Sootome, Hiroshi, Hirai, Hiroshi, Sagara, Takeshi

“…Deregulating fibroblast growth factor receptor (FGFR) signaling is a promising strategy for cancer therapy. Herein, we report the discovery of compound 5…”
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Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii by Maehara, Yoshihiko, Oki, Eiji, Ota, Mitsuhiko, Harimoto, Norifumi, Ando, Koji, Nakanishi, Ryota, Kawazoe, Tetsuro, Fujimoto, Yoshiaki, Nonaka, Kentaro, Kitao, Hiroyuki, Iimori, Makoto, Makino, Kunio, Takechi, Teiji, Sagara, Takeshi, Miyadera, Kazutaka, Matsuoka, Kazuaki, Tsukihara, Hiroshi, Kataoka, Yuki, Wakasa, Takeshi, Ochiiwa, Hiroaki, Kamahori, Yoshihiro, Tokunaga, Eriko, Saeki, Hiroshi, Yoshizumi, Tomoharu, Kakeji, Yoshihiro, Shirabe, Ken, Baba, Hideo, Shimada, Mitsuo

“…Prof. Setsuro Fujii achieved significant results in the field of drug discovery research in Japan. He developed nine well-known drugs: FT, UFT, S-1 and FTD/TPI…”
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Enhancing Findability and Searchability of Research Data: Metadata Conversion and Registration in Institutional Repositories by Nosé, Masahito, Shinbori, Atsuki, Miyoshi, Yoshizumi, Hori, Tomoaki, Ohira, Tsukasa, Hashiba, Junko, Naoe, Chizuko, Gakiya, Rui, Okamoto, Maiko, Sagara, Takeshi, Aoki, Takaaki, Matsubara, Shigeki, Takahashi, Ichiro, Hayashi, Hidekazu, Yamada, Kazunari, Minamiyama, Yasuyuki, Tanaka, Yoshimasa, Abe, Shuji, UeNo, Satoru, Imajo, Shun, Saito, Yasuo, Ashikita, Takuya, Hori, Yuko, Shimizu, Toshiyuki, Okamura, Nanako, Hirano, Kaoru, Bargatze, Lee

“…This paper outlines our practice to enhance the findability and searchability of research data through metadata conversion from the Space Physics Archive…”
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The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity by Wakasa, Takeshi, Nonaka, Kentaro, Harada, Akihito, Ohkawa, Yasuyuki, Kikutake, Chie, Suyama, Mikita, Kobunai, Takashi, Tsunekuni, Kenta, Matsuoka, Kazuaki, Kataoka, Yuki, Ochiiwa, Hiroaki, Miyadera, Kazutaka, Sagara, Takeshi, Oki, Eiji, Ohdo, Shigehiro, Maehara, Yoshihiko, Iimori, Makoto, Kitao, Hiroyuki

“…The fluorinated thymidine analog trifluridine (FTD) is a chemotherapeutic drug commonly used to treat cancer; however, the mechanism by which FTD induces…”
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Efficacy and safety of first-line or second-line selective laser trabeculoplasty for normal-tension glaucoma: a multicentre cohort study by Nitta, Koji, Sugihara, Kae, Narita, Akiko, Naito, Tomoko, Miki, Takako, Katai, Maki, Mizoue, Shiro, Yoshikawa, Keiji, Tanito, Masaki, Sugiyama, Kazuhisa, Nitta, Koji, Sugihara, Kae, Narita, Akiko, Naito, Tomoko, Miki, Takako, Katai, Maki, Mizoue, Shiro, Yoshikawa, Keiji, Tanito, Masaki, Sugiyama, Kazuhisa, Ikuno, Yasushi, Matsuda, Takuji, Ozaki, Hiroaki, Hirooka, Kazuyuki, Komatsu, Kaori, Saito, Yoshiaki, Kimura, Itaru, Kimura, Tairo, Sagara, Takeshi, Suzuki, Katsuyoshi, Tsutsui, Aika, Ishida, Akiko, Nakazawa, Toru, Tsuda, Satoru, Tsumura, Toyoaki, Tojo, Naoki, Tokuda, Naoto, Nakano, Tadashi, Watanabe, Tomoyuki, Nakamoto, Kenji, Shiratori, Naka, Nanno, Mami, Nezu, Naoya, Tasaka, Yoshitaka, Mori, Shigeru, Yamabayashi, Shigeki, Konno, Kimihito, Domoto, Miyuki

“…Background/aimsThis study aimed to investigate and compare the efficacy and safety of first-line and second-line selective laser trabeculoplasty (SLT) in…”
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Aromatic Substitution Reaction of 2-Chloropyridines Catalyzed by Microsomal Glutathione S-Transferase 1 by INOUE, Kazuko, OHE, Tomoyuki, MORI, Kenichi, SAGARA, Takeshi, ISHII, Yasuyuki, CHIBA, Masato

“…We investigated the substitution reaction of a series of 2-chloropyridine derivatives catalyzed by rat liver microsomal glutathione S -transferase 1. Various…”
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Induction by Latanoprost of Collagen Gel Contraction Mediated by Human Tenon Fibroblasts: Role of Intracellular Signaling Molecules by Liu, Yang, Ko, Ji-Ae, Yanai, Ryoji, Kimura, Kazuhiro, Chikama, Tai-ichiro, Sagara, Takeshi, Nishida, Teruo

“…The outcome of glaucoma filtration surgery is affected by subconjunctival wound healing. The effects of the antiglaucoma drug latanoprost on the contractility…”
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SLC1A1 Gene Variants and Normal Tension Glaucoma: An Association Study by Nishisako, Mami, Meguro, Akira, Nomura, Eiichi, Yamane, Takahiro, Takeuchi, Masaki, Ota, Masao, Kashiwagi, Kenji, Mabuchi, Fumihiko, Iijima, Hiroyuki, Kawase, Kazuhide, Yamamoto, Tetsuya, Nakamura, Makoto, Negi, Akira, Sagara, Takeshi, Nishida, Teruo, Inatani, Masaru, Tanihara, Hidenobu, Aihara, Makoto, Araie, Makoto, Fukuchi, Takeo, Abe, Haruki, Higashide, Tomomi, Sugiyama, Kazuhisa, Kanamoto, Takashi, Kiuchi, Yoshiaki, Iwase, Aiko, Chin, Shinki, Ohno, Shigeaki, Inoko, Hidetoshi, Mizuki, Nobuhisa

“…It has been hypothesized that dysfunction of the solute carrier family 1, member1 gene (SLC1A1), which encodes the glutamate aspartate transporter, may play a…”
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Effects of Antiglaucoma Drugs on Collagen Gel Contraction Mediated by Human Corneal Fibroblasts by Liu, Yang, Yanai, Ryoji, Lu, Ying, Hirano, Shinji, Sagara, Takeshi, Nishida, Teruo

“…PURPOSEMeasurement of intraocular pressure is affected by the shape and thickness of the cornea, and corneal shape is thought to be maintained by contraction…”
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Decrease in intraocular pressure following orthokeratology measured with a noncontact tonometer by Ishida, Yasuhito, Yanai, Ryoji, Sagara, Takeshi, Nishida, Teruo, Toshida, Hiroshi, Murakami, Akira

“…Purpose Orthokeratology for correction of myopia reduces corneal power by flattening corneal curvature and thinning central corneal thickness (CCT)…”
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Intraobserver and interobserver agreement of computer software-assisted optic nerve head photoplanimetry by Tanito, Masaki, Sagara, Takeshi, Takamatsu, Michiya, Kiuchi, Yoshiaki, Nakagawa, Toshiaki, Fujita, Yasuyuki, Ohira, Akihiro

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Permissive Effect of Fibronectin on Collagen Gel Contraction Mediated by Bovine Trabecular Meshwork Cells by Nakamura, Yoshikuni, Sagara, Takeshi, Seki, Keisuke, Hirano, Shinji, Nishida, Teruo

“…The effect of fibronectin on the contractility of trabecular meshwork (TM) cells was investigated. The contractility of bovine TM cells was evaluated by…”
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Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors by Sootome, Hiroshi, Fujita, Hidenori, Ito, Kenjiro, Ochiiwa, Hiroaki, Fujioka, Yayoi, Ito, Kimihiro, Miura, Akihiro, Sagara, Takeshi, Ito, Satoru, Ohsawa, Hirokazu, Otsuki, Sachie, Funabashi, Kaoru, Yashiro, Masakazu, Matsuo, Kenichi, Yonekura, Kazuhiko, Hirai, Hiroshi

“…FGFR signaling is deregulated in many human cancers, and FGFR is considered a valid target in FGFR-deregulated tumors. Here, we examine the preclinical profile…”
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Pupillary block in Peters’ anomaly by Sagara, Takeshi, Kozawa, Maki, Ota, Kayoko, Fujitsu, Yoichiro, Suzuki, Katsuyoshi, Nishida, Teruo

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Fundus photoplanimetry of the optic nerve head in the Sakurae Study by Tanito, Masaki, Sagara, Takeshi, Takamatsu, Michiya, Kiuchi, Yoshiaki, Nakagawa, Toshiaki, Fujita, Yasuyuki, Ohira, Akihiro

“…To explore the fundus photoplanimetric distribution of the optic nerve head in a population-based health survey conducted in Sakurae area, in Shimane,…”
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Aqueous humor dynamics associated with the phorbol ester-induced decrease in intraocular pressure in the rabbit by Oka, Takayuki, Taniguchi, Toru, Kitazawa, Yoshiaki, Sagara, Takeshi, Nishida, Teruo

“…To determine the effects of injection of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) into the anterior chamber of the eye on…”
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Additional reduction in intraocular pressure achieved with latanoprost in normal-tension glaucoma patients previously treated with unoprostone by Enoki, Miho, Saito, Jun, Hara, Makiko, Uchida, Tetsuya, Sagara, Takeshi, Nishida, Teruo

“…To determine whether treatment with latanoprost eye drops is able to further reduce intraocular pressure (IOP) in normal-tension glaucoma (NTG) patients whose…”
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Abstract A063: TAS1553, a novel class of RNR inhibitor, demonstrates synergistic antitumor efficacy in combination with nucleoside analogues by Hoshino, Takuya, Ueno, Hiroyuki, Yano, Wakako, Tsukioka, Sayaka, Miyahara, Seiji, Suzuki, Takamasa, Miyadera, Kazutaka, Utsugi, Teruhiro, Sagara, Takeshi

“…Background: Ribonucleotide reductase (RNR) is an essential metabolic enzyme that catalyzes a rate-limiting step for de novo dNTP biosynthesis via converting…”
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The Efficacy, Safety, and Satisfaction Associated with Switching from Brinzolamide or Brimonidine to Brinzolamide/Brimonidine in Open-Angle Glaucoma Patients by Onoe, Hiromitsu, Hirooka, Kazuyuki, Nagayama, Mikio, Mochizuki, Hideki, Hirota, Atsushi, Suzuki, Katsuyoshi, Sagara, Takeshi, Kiuchi, Yoshiaki

“…We evaluated switching from brinzolamide 1% or brimonidine 0.1% to a fixed-combination of brinzolamide 1% and brimonidine 0.1%, and then determined the…”
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