Search Results - "SAETTA, Marina"

Immunologic Aspects of Chronic Obstructive Pulmonary Disease by Cosio, Manuel G, Saetta, Marina, Agusti, Alvar

“…This review is an account of how pulmonary damage caused by cigarette smoke and other environmental toxins can incite inflammatory and immunologic reactions…”
Get full text

Severe asthma: phenotyping to endotyping or vice versa? by Papi, Alberto, Saetta, Marina, Fabbri, Leonardo

“…The most recent definition of asthma is that it is a heterogeneous disease, usually characterised by chronic airway inflammation, defined by a history of…”
Get full text

Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today by Bazzan, Erica, Tinè, Mariaenrica, Casara, Alvise, Biondini, Davide, Semenzato, Umberto, Cocconcelli, Elisabetta, Balestro, Elisabetta, Damin, Marco, Radu, Claudia Maria, Turato, Graziella, Baraldo, Simonetta, Simioni, Paolo, Spagnolo, Paolo, Saetta, Marina, Cosio, Manuel G.

“…Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of…”
Get full text

Blood Eosinophilia Neither Reflects Tissue Eosinophils nor Worsens Clinical Outcomes in Chronic Obstructive Pulmonary Disease by Turato, Graziella, Semenzato, Umberto, Bazzan, Erica, Biondini, Davide, Tinè, Mariaenrica, Torrecilla, Nerea, Forner, Marta, Marin, Josè M, Cosio, Manuel G, Saetta, Marina

“…To the Editor: The role of the blood eosinophil count as a biomarker predictor of the frequency of exacerbations and response to corticosteroid treatment in…”
Get full text

Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis by Balestro, Elisabetta, Calabrese, Fiorella, Turato, Graziella, Lunardi, Francesca, Bazzan, Erica, Marulli, Giuseppe, Biondini, Davide, Rossi, Emanuela, Sanduzzi, Alessandro, Rea, Federico, Rigobello, Chiara, Gregori, Dario, Baraldo, Simonetta, Spagnolo, Paolo, Cosio, Manuel G, Saetta, Marina

“…The clinical course in idiopathic pulmonary fibrosis (IPF) is highly heterogeneous, with some patients having a slow progression and others an accelerated…”
Get full text

The Role of the Lung's Microbiome in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis by Spagnolo, Paolo, Molyneaux, Philip L, Bernardinello, Nicol, Cocconcelli, Elisabetta, Biondini, Davide, Fracasso, Federico, Tiné, Mariaenrica, Saetta, Marina, Maher, Toby M, Balestro, Elisabetta

“…Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease that commonly affects older adults and is associated with…”
Get full text

Molecular Mechanism in the Development of Pulmonary Fibrosis in Patients with Sarcoidosis by Cocconcelli, Elisabetta, Bernardinello, Nicol, Castelli, Gioele, Petrarulo, Simone, Bellani, Serena, Saetta, Marina, Spagnolo, Paolo, Balestro, Elisabetta

“…Sarcoidosis is a multisystemic disease of unknown etiology characterized by the formation of granulomas in various organs, especially lung and mediastinal…”
Get full text

Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment by Biondini, Davide, Cocconcelli, Elisabetta, Bernardinello, Nicol, Lorenzoni, Giulia, Rigobello, Chiara, Lococo, Sara, Castelli, Gioele, Baraldo, Simonetta, Cosio, Manuel G, Gregori, Dario, Saetta, Marina, Balestro, Elisabetta, Spagnolo, Paolo

“…A common variant located in the promoter region of MUC5B (rs35705950) is the strongest risk factor for sporadic and familiar IPF, as well as a predictor of…”
Get full text

Extracellular Vesicles (EVs) as Crucial Mediators of Cell-Cell Interaction in Asthma by Tinè, Mariaenrica, Padrin, Ylenia, Bonato, Matteo, Semenzato, Umberto, Bazzan, Erica, Conti, Maria, Saetta, Marina, Turato, Graziella, Baraldo, Simonetta

“…Asthma is the most common chronic respiratory disorder worldwide and accounts for a huge health and economic burden. Its incidence is rapidly increasing but,…”
Get full text

Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma by Baraldo, Simonetta, PhD, Contoli, Marco, MD, PhD, Bazzan, Erica, PhD, Turato, Graziella, PhD, Padovani, Anna, BSc, Marku, Brunilda, MD, Calabrese, Fiorella, MD, Caramori, Gaetano, MD, PhD, Ballarin, Andrea, MD, Snijders, Deborah, MD, Barbato, Angelo, MD, Saetta, Marina, MD, Papi, Alberto, MD

“…Background Impaired immune response to viral infections in atopic asthmatic patients has been recently reported and debated. Whether this condition is present…”
Get full text

Radiological Assessment in Idiopathic Pulmonary Fibrosis (IPF) Patients According to MUC5B Polymorphism by Cocconcelli, Elisabetta, Bernardinello, Nicol, Giraudo, Chiara, Castelli, Gioele, Greco, Clorinda, Polverosi, Roberta, Saetta, Marina, Spagnolo, Paolo, Balestro, Elisabetta

“…The rs35705950 mutant T allele is the strongest genetic risk factor for familial and sporadic IPF. We sought to determine whether genotype influences…”
Get full text

The Emerging Role of Extracellular Vesicles Detected in Different Biological Fluids in COPD by Neri, Tommaso, Celi, Alessandro, Tinè, Mariaenrica, Bernardinello, Nicol, Cosio, Manuel G, Saetta, Marina, Nieri, Dario, Bazzan, Erica

“…The pathogenesis of chronic obstructive pulmonary disease (COPD) is characterized by complex cellular and molecular mechanisms, not fully elucidated so far. It…”
Get full text

Expression of human Interferon Regulatory Factor 3 (IRF-3) in alveolar macrophages relates to clinical and functional traits in COPD by Baraldo, Simonetta, Bonato, Matteo, Cassia, Sebastiano, Casolari, Paolo, De Ferrari, Laura, Tiné, Mariaenrica, Baraldi, Federico, Bigoni, Tommaso, Riccio, Anna Maria, Braido, Fulvio, Saetta, Marina, Papi, Alberto, Contoli, Marco

“…Chronic obstructive pulmonary disease (COPD) is a frequent cause of morbidity and mortality. Dysregulated and enhanced immune-inflammatory responses have been…”
Get full text

Unveiling the Cutting-Edge Impact of Polarized Macrophage-Derived Extracellular Vesicles and MiRNA Signatures on TGF-β Regulation within Lung Fibroblasts by Casara, Alvise, Conti, Maria, Bernardinello, Nicol, Tinè, Mariaenrica, Baraldo, Simonetta, Turato, Graziella, Semenzato, Umberto, Celi, Alessandro, Spagnolo, Paolo, Saetta, Marina, Cosio, Manuel G, Neri, Tommaso, Biondini, Davide, Bazzan, Erica

“…Depending on local cues, macrophages can polarize into classically activated (M1) or alternatively activated (M2) phenotypes. This study investigates the…”
Get full text

Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up by Contoli, Marco, MD, PhD, Baraldo, Simonetta, PhD, Marku, Brunilda, MD, Casolari, Paolo, PhD, Marwick, John A., PhD, Turato, Graziella, PhD, Romagnoli, Micaela, MD, PhD, Caramori, Gaetano, MD, PhD, Saetta, Marina, MD, Fabbri, Leonardo M., MD, Papi, Alberto, MD

“…Background Both smokers and patients with asthma can experience fixed airflow obstruction, which is associated with distinctive patterns of airway pathology…”
Get full text

Immune activation in α1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm by Baraldo, Simonetta, Turato, Graziella, Lunardi, Francesca, Bazzan, Erica, Schiavon, Marco, Ferrarotti, Ilaria, Molena, Beatrice, Cazzuffi, Riccardo, Damin, Marco, Balestro, Elisabetta, Luisetti, Maurizio, Rea, Federico, Calabrese, Fiorella, Cosio, Manuel G, Saetta, Marina

“…α1-Antitrypsin (AAT) is a potent protease inhibitor, deficiency of which is associated with the presence of emphysema. An imbalance of elastase and…”
Get full text

Air Pollution Exposure Impairs Airway Epithelium IFN-β Expression in Pre-School Children by Bonato, Matteo, Gallo, Elisa, Turrin, Martina, Bazzan, Erica, Baraldi, Federico, Saetta, Marina, Gregori, Dario, Papi, Alberto, Contoli, Marco, Baraldo, Simonetta

“…Air pollution is a risk factor for respiratory infections and asthma exacerbations. We previously reported impaired Type-I and Type-III interferons (IFN-β/λ)…”
Get full text

Do Circulating Extracellular Vesicles Strictly Reflect Bronchoalveolar Lavage Extracellular Vesicles in COPD? by Tinè, Mariaenrica, Neri, Tommaso, Biondini, Davide, Bernardinello, Nicol, Casara, Alvise, Conti, Maria, Minniti, Marianna, Cosio, Manuel G, Saetta, Marina, Celi, Alessandro, Nieri, Dario, Bazzan, Erica

“…Cell-derived extracellular vesicles (EVs) found in the circulation and body fluids contain biomolecules that could be used as biomarkers for lung and other…”
Get full text

Airway inflammation in chronic obstructive pulmonary disease by SAETTA, M

“…Cigarette smoking causes an inflammatory process in the central airways, peripheral airways, and lung parenchyma, even in smokers with normal lung function…”
Get full text

High-flow nasal cannula oxygen therapy to treat acute respiratory failure in patients with acute exacerbation of idiopathic pulmonary fibrosis by Vianello, Andrea, Arcaro, Giovanna, Molena, Beatrice, Turato, Cristian, Braccioni, Fausto, Paladini, Luciana, Vio, Stefania, Ferrarese, Silvia, Peditto, Piera, Gallan, Federico, Saetta, Marina

“…Background: Some patients with idiopathic pulmonary fibrosis (IPF) develop acute exacerbation (AE-IPF) leading to severe acute respiratory failure (ARF);…”
Get full text