Search Results - "SAEKI, K"

Adjunctive perampanel in partial‐onset seizures: Asia‐Pacific, randomized phase III study by Nishida, T., Lee, S. K., Inoue, Y., Saeki, K., Ishikawa, K., Kaneko, S.

“…Objectives To evaluate the efficacy, safety, and tolerability of perampanel, a selective, non‐competitive, α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid…”
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Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial‐onset seizures by Takenaka, O., Ferry, J., Saeki, K., Laurenza, A.

“…Objectives Explore perampanel pharmacokinetics (PK) in all subjects (aged ≥12 years) vs adolescents (aged ≥12 to ≤17 years) with partial‐onset seizures (POS)…”
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FAM115c that upregulates proliferation and invasion under hypoxia could be a predictive biomarker for pancreatic cancer by Saeki, K., Onishi, H., Oda, Y., Nakamura, M.

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Association of low back pain and sleep quality with presenteeism by Tezuka, M, Oka, T, Nakatsuka, K, Saeki, K, Ono, R

“…Low back pain (LBP) and poor subjective sleep quality (SSQ) are major risk factors for presenteeism. However, no studies have investigated whether combined LBP…”
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Working hours, occupational stress and depression among physicians by TOMIOKA, K, MORITA, N, SAEKI, K, OKAMOTO, N, KURUMATANI, N

“…Physicians report high prevalence of depression, work long hours and are exposed to many occupational stresses (OSs). To investigate the cross-sectional…”
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Thermoluminescence and optically stimulated luminescence properties of Dy3+-doped CaO–Al2O3–B2O3-based glasses by Yahaba, T., Fujimoto, Y., Yanagida, T., Koshimizu, M., Tanaka, H., Saeki, K., Asai, K.

“…We developed Dy3+-doped CaO–Al2O3–B2O3 based glasses with Dy concentrations of 0.5, 1.0, and 2.0mol% using a melt-quenching technique. The as-synthesized…”
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Evaluation of epithelial and mesenchymal cell markers in canine urinary bladder transitional cell carcinoma by Shinada, M., Saeki, K., Yoshitake, R., Eto, S., Tsuboi, M., Chambers, J.K., Uchida, K., Kato, D., Yoshimoto, S., Kamoto, S., Ikeda, N., Kinoshita, R., Fujita, N., Nishimura, R., Nakagawa, T.

“…•Canine transitional cell carcinoma (cTCC) is invasive and metastatic.•Epithelial-mesenchymal transition contributed to tumour invasion and…”
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The relationship between indoor, outdoor and ambient temperatures and morning BP surges from inter-seasonally repeated measurements by Saeki, K, Obayashi, K, Iwamoto, J, Tone, N, Okamoto, N, Tomioka, K, Kurumatani, N

“…Higher morning blood pressure (BP) surge is a risk factor for cardiovascular disease independent of 24-h mean BP. Although low outdoor temperatures are…”
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Distinct decalcification process of dentin by different cariogenic organic acids: Kinetics, ultrastructure and mechanical properties by Chien, Y-C, Burwell, A.K, Saeki, K, Fernandez-Martinez, A, Pugach, M.K, Nonomura, G, Habelitz, S, Ho, S.P, Rapozo-Hilo, M, Featherstone, J.D, Marshall, S.J, Marshall, G.W

“…Highlights • Lactate and acetate buffers had different demineralization kinetics at pH 5. • Elastic modulus of lactate and acetate demineralized lesions is…”
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Molecular investigation of the direct anti-tumour effects of nonsteroidal anti-inflammatory drugs in a panel of canine cancer cell lines by Yoshitake, R., Saeki, K., Watanabe, M., Nakaoka, N., Ong, S.M., Hanafusa, M., Choisunirachon, N., Fujita, N., Nishimura, R., Nakagawa, T.

“…•Nonsteroidal anti-inflammatory drugs (NSAIDs) are promising cancer therapeutics.•Cyclooxygenase (COX)-related molecule expression vs. NSAID sensitivity was…”
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Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma by Yoshitake, Ryohei, Saeki, Kohei, Eto, Shotaro, Shinada, Masahiro, Nakano, Rei, Sugiya, Hiroshi, Endo, Yoshifumi, Fujita, Naoki, Nishimura, Ryohei, Nakagawa, Takayuki

“…Cancer-promoting inflammation is an important event in cancer development. Canine urothelial carcinoma (cUC) overexpresses prostaglandin E 2 (PGE 2 ) and has a…”
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Recovery after PILP remineralization of dentin lesions created with two cariogenic acids by Saeki, K, Chien, Y-C, Nonomura, G, Chin, A.F, Habelitz, S, Gower, L.B, Marshall, S.J, Marshall, G.W

“…Highlights • Acetate and lactate made different residual dentin structures in artificial lesions. • PILP process recovered both structure and mechanical…”
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The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction by Yoshimura, Akihiko, Saeki, Kazuko, Miura, Yoshiki, Aki, Daisuke, Kurosaki, Tomohiro

“…Recent evidence indicates that membrane microdomains, termed lipid rafts, have a role in B‐cell activation as platforms for B‐cell antigen receptor (BCR)…”
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Expression of the Short Form of RON/STK in Feline Mammary Carcinoma by Maniscalco, Lorella, Guil-Luna, Silvia, Iussich, Selina, Gattino, Francesca, Trupia, Calogero, Millan, Yolanda, de Las Mulas, Juana Martín, Cespedez, Raquel Sanchez, Saeki, K., Accornero, Paolo, De Maria, Raffaella

“…RON is a tyrosine kinase receptor activated by the macrophage-stimulating protein (MSP) ligand that is overexpressed in human breast cancer. In humans, RON…”
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Effects of etoposide alone and in combination with piroxicam on canine osteosarcoma cell lines by Ong, S.M., Saeki, K., Tanaka, Y., Nishimura, R., Nakagawa, T.

“…•Canine osteosarcoma (OSA) is highly malignant and has a poor overall survival rate.•The effects of etoposide against canine OSA with or without piroxicam were…”
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Repair of dentin defects from DSPP knockout mice by PILP mineralization by Nurrohman, Hamid, Saeki, Kunkio, Carneiro, Karina M.M., Chien, Yung-Ching, Djomehri, Sabra, Ho, Sunita P., Qin, Chunlin, Gower, Laurie B., Marshall, Sally J., Marshall, Grayson W., Habelitz, Stefan

“…Dentinogenesis imperfecta type II (DGI-II) lacks intrafibrillar mineral with severe compromise of dentin mechanical properties. A Dspp knockout (Dspp –/–)…”
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Anti-tumour efficacy of etoposide alone and in combination with piroxicam against canine osteosarcoma in a xenograft model by Ong, S.M., Saeki, K., Kok, M.K., Tanaka, Y., Choisunirachon, N., Yoshitake, R., Nishimura, R., Nakagawa, T.

“…Osteosarcoma (OSA) in dogs is locally invasive and highly malignant. Distant metastasis is the most common cause of death. To date, the survival rate in dogs…”
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Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells by Saeki, K, Yuo, A, Okuma, E, Yazaki, Y, Susin, S A, Kroemer, G, Takaku, F

“…To understand the roles of bcl-2 for the survival of leukemic cells, we constructed human leukemic HL60 transformant lines in which full length bcl-2 antisense…”
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Anti-tumour effect of metformin in canine mammary gland tumour cells by Saeki, K., Watanabe, M., Tsuboi, M., Sugano, S., Yoshitake, R., Tanaka, Y., Ong, S.M., Saito, T., Matsumoto, K., Fujita, N., Nishimura, R., Nakagawa, T.

“…•Metformin is a mitochondrial respiratory chain complex inhibitor (MRCI).•MRCIs are potent anti-tumour agents and metformin may be clinically…”
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Gene silencing of STAT6 with siRNA ameliorates contact hypersensitivity and allergic rhinitis by Hosoya, K, Satoh, T, Yamamoto, Y, Saeki, K, Igawa, K, Okano, M, Moriya, T, Imamura, O, Nemoto, Y, Yokozeki, H

“…To cite this article: Hosoya K, Satoh T, Yamamoto Y, Saeki K, Igawa K, Okano M, Moriya T, Imamura O, Nemoto Y, Yokozeki H. Gene silencing of STAT6 with siRNA…”
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