Search Results - "SAEHO CHONG"

Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N -Acetylgalactosamine-Conjugated RNA Interference Therapeutic by Li, Jing, Liu, Ju, Zhang, Xuemei, Clausen, Valerie, Tran, Chris, Arciprete, Michael, Wang, Qianfan, Rocca, Carrie, Guan, Li-Hua, Zhang, Guodong, Najarian, Diana, Xu, Yuanxin, Smith, Peter, Wu, Jing-Tao, Chong, Saeho

“…Givosiran is an -acetylgalactosamine-conjugated RNA interference therapeutic that targets 5'-aminolevulinate synthase 1 mRNA in the liver and is currently…”
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Chitosan oligosaccharide–arachidic acid-based nanoparticles for anti-cancer drug delivery by Termsarasab, Ubonvan, Cho, Hyun-Jong, Kim, Dong Hwan, Chong, Saeho, Chung, Suk-Jae, Shim, Chang-Koo, Moon, Hyun Tae, Kim, Dae-Duk

“…Chitosan oligosaccharide–arachidic acid (CSOAA) was synthesized and doxorubicin (DOX)-loaded CSOAA-based self-assembled nanoparticles were prepared…”
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Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet by Cho, Sung-Joon, Kim, Sang-Bum, Cho, Hyun-Jong, Chong, Saeho, Chung, Suk-Jae, Kang, Il-Mo, Lee, Jangik Ike, Yoon, In-Soo, Kim, Dae-Duk

“…Nonalcoholic fatty liver disease (NAFLD) refers to hepatic pathologies, including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH), fibrosis, and…”
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In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism by Kim, Sang-Bum, Yoon, In-Soo, Kim, Kyu-Sang, Cho, Sung-Jun, Kim, Yeong Shik, Cho, Hyun-Jong, Chung, Suk-Jae, Chong, Saeho, Kim, Dae-Duk

“…Puerarin (8-β-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a major pharmacological component of Puerariae Radix, the root of…”
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PLAG (1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol) Modulates Eosinophil Chemotaxis by Regulating CCL26 Expression from Epithelial Cells by Jeong, Jinseon, Kim, Young-Jun, Yoon, Sun Young, Kim, Yong-Jae, Kim, Joo Heon, Sohn, Ki-Young, Kim, Heung-Jae, Han, Yong-Hae, Chong, Saeho, Kim, Jae Wha

“…Increased number of eosinophils in the circulation and sputum is associated with the severity of asthma. The respiratory epithelium produces chemokine (C-C…”
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Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats by Zhang, Hongjian, Yao, Ming, Morrison, Richard A, Chong, Saeho

“…Tween 80 (Polysorbate 80) is a hydrophilic nonionic surfactant commonly used as an ingredient in dosing vehicles for pre-clinical in vivo studies (e.g.,…”
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Enhanced metabolism of indinavir and formation of M6, the major metabolite, by the co-administration of HM-30181, a selective p-glycoprotein inhibitor by Ryu, Heon-Min, Jeong, Yoo-Seong, Chong, Saeho, Lee, Wooin, Kim, Dae-Duk, Chung, Suk-Jae

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Comparison of saline vs. blood replenishment after blood sampling in a rat pharmacokinetic study by Kim, Sang-Bum, Kim, Kyu-Sang, Ryu, Heon-Min, Yoon, In-Soo, Cho, Hyun-Jong, Chung, Suk-Jae, Chong, Saeho, Kim, Dae-Duk

“…The objective of this study was to examine the effect of reduced hematocrit and plasma protein levels, which may occur in rats after normal saline…”
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Induction of heme oxygenase-1 (HO-1) and NAD[P]H : Quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert -butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes by KEUM, Young-Sam, HAN, Yong-Hae, LIEW, Celine, KIM, Jung-Hwan, CHANGJIANG XU, XIAOLING YUAN, SHAKARJIAN, Michael P, CHONG, Saeho, KONG, Ah-Ng

“…This study was aimed to investigate the effects of a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) on…”
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Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers by TAVELIN, Staffan, TAIPALENSUU, Jan, SÖDERBERG, Lauri, MORRISON, Rick, SAEHO CHONG, ARTURSSON, Per

“…To characterize the paracellular route of 2/4/A1 monolayers and to compare the permeabilities of incompletely absorbed oral drugs in 2/4/A1 with those in…”
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Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds by Marino, Anthony M., Yarde, Melissa, Patel, Hetal, Chong, Saeho, Balimane, Praveen V.

“…The use of Caco-2 cells for permeability screening of discovery compounds is quite well established and serves as the “method-of-choice” across the…”
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Effect of fruit juices on the oral bioavailability of fexofenadine in rats by Kamath, Amrita V, Yao, Ming, Zhang, Yueping, Chong, Saeho

“…Fexofenadine has been identified as a substrate for both the efflux transporter, P-glycoprotein (P-gp), as well as the influx transporter, organic anion…”
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Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery by Balimane, Praveen V, Patel, Karishma, Marino, Anthony, Chong, Saeho

“…The use of Caco-2 cells for screening of discovery compounds for their permeability characteristics and P-glycoprotein interactions is well established and…”
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In Silico Prediction of Biliary Excretion of Drugs in Rats Based on Physicochemical Properties by GANG LUO, JOHNSON, Stephen, HSUEH, Mei-Mann, ZHENG, Joanna, HONG CAI, BAOMIN XIN, SAEHO CHONG, KAN HE, HARPER, Timothy W

“…Evaluating biliary excretion, a major elimination pathway for many compounds, is important in drug discovery. The bile duct-cannulated (BDC) rat model is…”
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Functional consequences of genetic variations in the human organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population by Chae, Yoon-Jee, Lee, Kyeong-Ryoon, Noh, Chi-Kyung, Chong, Saeho, Kim, Dae-Duk, Shim, Chang-Koo, Chung, Suk-Jae

“…The objectives of this study were to investigate the allele frequencies and linkage disequilibrium (LD) in the organic anion transporting polypeptide 1B3…”
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Lack of a Primary Physicochemical Determinant in the Direct Transport of Drugs to the Brain after Nasal Administration in Rats: Potential Involvement of Transporters in the Pathway by Lee, Kyeong-Ryoon, Maeng, Han-Joo, Chae, Jung-Byung, Chong, Saeho, Kim, Dae-Duk, Shim, Chang-Koo, Chung, Suk-Jae

“…The objectives of this study were to evaluate the relative contribution of the direct pathway in overall brain transport for 17 model drugs with different…”
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Functional Impairment of Rat Taurine Transporter by Activation of Nitrogen Oxide through Superoxide by Koo, Tae-Sung, Kwon, Hyun-Jung, Kim, Mi-Hwa, Kim, Dae-Duk, Shim, Chang-Koo, Chung, Suk-Jae, Chong, Saeho

“…The objective of this study was to identify the nitrogen oxide form(s) involved in the functional impairment of the rat taurine transport system. Taurine…”
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1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) Modulates Th2 Immunity through Attenuation of IL-4 Expression by Yoon, Sun Young, Kang, Ho Bum, Ko, Young-Eun, Shin, Su-Hyun, Kim, Young-Jun, Sohn, Ki-Young, Han, Yong-Hae, Chong, Saeho, Kim, Jae Wha

“…Controlling balance between T-helper type 1 (Th1) and T-helper type 2 (Th2) plays a pivotal role in maintaining the biological rhythm of Th1/Th2 and…”
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Discovery of (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity by Hunt, John T, Ding, Charles Z, Batorsky, Roberta, Bednarz, Mark, Bhide, Rajeev, Cho, Young, Chong, Saeho, Chao, Sam, Gullo-Brown, Johnni, Guo, Peng, Kim, Soong Hoon, Lee, Francis Y. F, Leftheris, Katerina, Miller, Arthur, Mitt, Toomas, Patel, Manorama, Penhallow, Becky A, Ricca, Carol, Rose, William C, Schmidt, Robert, Slusarchyk, William A, Vite, Gregory, Manne, Veeraswamy

“…Continuing structure−activity studies were performed on the 2,3,4,5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors…”
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A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma by Yao, Ming, Zhang, Hongjian, Chong, Saeho, Zhu, Mingshe, Morrison, Richard A

“…Digoxin is a cardiac glycoside that is widely used for the treatment of congestive heart failure. To evaluate pharmacokinetics of digoxin in rats, a sensitive…”
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