Search Results - "SADEJ, Rafal"

FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors - implications for therapy of luminal breast cancer by Piasecka, Dominika, Braun, Marcin, Kitowska, Kamila, Mieczkowski, Kamil, Kordek, Radzislaw, Sadej, Rafal, Romanska, Hanna

“…Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in…”
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Dual, enzymatic and non-enzymatic, function of ecto-5'-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells by Sadej, Rafal, Skladanowski, Andrzej C

“…Ecto-5'-nucleotidase (eN, CD73) mediates extracellular adenosine production from 5'-AMP. Non-enzymatic functions of eN have also been reported. The aim of the…”
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Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli by Piasecka, Dominika, Braun, Marcin, Mieszkowska, Magdalena, Kowalczyk, Lukasz, Kopczynski, Janusz, Kordek, Radzislaw, Sadej, Rafal, Romanska, Hanna M.

“…There are data to suggest that some ductal carcinoma in situ (DCIS) may evolve through an evolutionary bottleneck, where minor clones susceptible to the…”
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FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells by Turczyk, Lukasz, Kitowska, Kamila, Mieszkowska, Magdalena, Mieczkowski, Kamil, Czaplinska, Dominika, Piasecka, Dominika, Kordek, Radzisław, Skladanowski, Andrzej C., Potemski, Piotr, Romanska, Hanna M., Sadej, Rafal

“…Signaling mediated by growth factors receptors has long been suggested as one of the key factors responsible for failure of endocrine treatment in breast…”
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FGFR2-triggered autophagy and activation of Nrf-2 reduce breast cancer cell response to anti-ER drugs by Gorska-Arcisz, Monika, Popeda, Marta, Braun, Marcin, Piasecka, Dominika, Nowak, Joanna I, Kitowska, Kamila, Stasilojc, Grzegorz, Okroj, Marcin, Romanska, Hanna M, Sadej, Rafal

“…Genetic abnormalities in the FGFR signalling occur in 40% of breast cancer (BCa) patients resistant to anti-ER therapy, which emphasizes the potential of…”
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FGF7/FGFR2–JunB signalling counteracts the effect of progesterone in luminal breast cancer by Mieczkowski, Kamil, Kitowska, Kamila, Braun, Marcin, Galikowska‐Bogut, Barbara, Gorska‐Arcisz, Monika, Piasecka, Dominika, Stawiski, Konrad, Zaczek, Anna J., Nejc, Dariusz, Kordek, Radzisław, Romanska, Hanna M., Sadej, Rafal

“…We have recently demonstrated that fibroblast growth factor receptor 2 (FGFR2)‐mediated signalling alters progesterone receptor (PR) activity and response of…”
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MET-Pyk2 Axis Mediates Acquired Resistance to FGFR Inhibition in Cancer Cells by Kitowska, Kamila, Gorska-Arcisz, Monika, Antoun, Dima, Zarczynska, Izabela, Czaplinska, Dominika, Szczepaniak, Adrian, Skladanowski, Andrzej C, Wieczorek, Maciej, Stanczak, Aleksandra, Skupinska, Monika, Sadej, Rafal

“…Deregulation of fibroblast growth factor receptors (FGFRs) signaling, as a result of amplification, chromosomal translocation, or mutations, is involved in…”
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Clinical and Biological Significance of ESR1 Gene Alteration and Estrogen Receptors Isoforms Expression in Breast Cancer Patients by Nagel, Anna, Szade, Jolanta, Iliszko, Mariola, Elzanowska, Julia, Welnicka-Jaskiewicz, Marzena, Skokowski, Jaroslaw, Stasilojc, Grzegorz, Bigda, Jacek, Sadej, Rafal, Zaczek, Anna, Markiewicz, Aleksandra

“…The amplification of estrogen receptor alpha (ERα) encoded by the gene has been described as having a prognostic role in breast cancer patients. However,…”
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Suppression of Integrin α3β1 in Breast Cancer Cells Reduces Cyclooxygenase-2 Gene Expression and Inhibits Tumorigenesis, Invasion, and Cross-Talk to Endothelial Cells by MITCHELL, Kara, SVENSON, Kimberly B, LONGMATE, Whitney M, GKIRTZIMANAKI, Katerina, SADEJ, Rafal, XIANHUI WANG, JIHE ZHAO, ELIOPOULOS, Aristides G, BERDITCHEVSKI, Fedor, MICHAEL DIPERSIO, C

“…Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin α3β1 is highly expressed…”
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Subtype-Specific Tumour Immune Microenvironment in Risk of Recurrence of Ductal Carcinoma In Situ: Prognostic Value of HER2 by Solek, Julia, Chrzanowski, Jedrzej, Cieslak, Adrianna, Zielinska, Aleksandra, Piasecka, Dominika, Braun, Marcin, Sadej, Rafal, Romanska, Hanna M

“…Increasing evidence suggests that the significance of the tumour immune microenvironment (TIME) for disease prognostication in invasive breast carcinoma is…”
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p38 Mediates Resistance to FGFR Inhibition in Non-Small Cell Lung Cancer by Zarczynska, Izabela, Gorska-Arcisz, Monika, Cortez, Alexander Jorge, Kujawa, Katarzyna Aleksandra, Wilk, Agata Małgorzata, Skladanowski, Andrzej Cezary, Stanczak, Aleksandra, Skupinska, Monika, Wieczorek, Maciej, Lisowska, Katarzyna Marta, Sadej, Rafal, Kitowska, Kamila

“…FGFR signalling is one of the most prominent pathways involved in cell growth and development as well as cancer progression. FGFR1 amplification occurs in…”
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CD151 Regulates Tumorigenesis by Modulating the Communication between Tumor Cells and Endothelium by Sadej, Rafal, Romanska, Hanna, Baldwin, Gouri, Gkirtzimanaki, Katerina, Novitskaya, Vera, Filer, Andrew D, Krcova, Zuzana, Kusinska, Renata, Ehrmann, Jiri, Buckley, Christopher D, Kordek, Radzislaw, Potemski, Piotr, Eliopoulos, Aristides G, Lalani, El-Nasir, Berditchevski, Fedor

“…The tetraspanin CD151 forms stoichiometric complexes with laminin-binding integrins (e.g., α3β1, α6β1, and α6β4) and regulates their ligand-binding and…”
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A 'Real-Life' Experience on Automated Digital Image Analysis of FGFR2 Immunohistochemistry in Breast Cancer by Braun, Marcin, Piasecka, Dominika, Bobrowski, Mateusz, Kordek, Radzislaw, Sadej, Rafal, Romanska, Hanna M

“…We present here an assessment of a 'real-life' value of automated machine learning algorithm (AI) for examination of immunohistochemistry for fibroblast growth…”
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MicroRNAs in regulation of triple-negative breast cancer progression by Piasecka, Dominika, Braun, Marcin, Kordek, Radzislaw, Sadej, Rafal, Romanska, Hanna

“…Purpose Dysregulation of miRNA profile has been associated with a broad spectrum of cellular processes underlying progression of various human malignancies…”
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Tetraspanin CD151 Regulates Transforming Growth Factor β Signaling: Implication in Tumor Metastasis by SADEJ, Rafat, ROMANSKA, Hanna, KAVANAGH, Dean, BALDWIN, Gouri, TAKAHASHI, Takashi, KALIA, Neena, BERDITCHEVSKI, Fedor

“…Tetraspanin CD151 is associated with laminin-binding integrins and controls tumor cell migration and invasion. By analyzing responses of breast cancer cells to…”
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FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation by Mieczkowski, Kamil, Popeda, Marta, Lesniak, Dagmara, Sadej, Rafal, Kitowska, Kamila

“…The role of fibroblast growth factor receptor 2 (FGFR2), an important mediator of stromal paracrine and autocrine signals, in mammary gland morphogenesis and…”
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FGFR4-driven plasticity in breast cancer progression and resistance to therapy by Braun, Marcin, Piasecka, Dominika, Sadej, Rafal, Romanska, Hanna M.

“…Breast cancer (BCa) is a complex and heterogeneous disease, with different intrinsic molecular subtypes that have distinct clinical outcomes and responses to…”
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FGFR‑related phenotypic and functional profile of CAFs in prognostication of breast cancer (Review) by Solek, Julia, Braun, Marcin, Sadej, Rafal, Romanska, Hanna M

“…While preclinical studies consistently implicate FGFR‑signalling in breast cancer (BC) progression, clinical evidence fails to support these findings. It may…”
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CD151 in cancer progression and metastasis: a complex scenario by Sadej, Rafal, Grudowska, Alicja, Turczyk, Lukasz, Kordek, Radzislaw, Romanska, Hanna M

“…Originally identified as a molecular organizer of interacting proteins into tetraspanin-enriched microdomains, the tetraspanin CD151 has now been shown to be…”
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Bioglass obtained via one-pot synthesis as osseointegrative drug delivery system by Skwira, Adrianna, Szewczyk, Adrian, Sądej, Rafał, Prokopowicz, Magdalena

“…[Display omitted] Osseointegration is a fundamental process during which implantable biomaterial integrates with host bone tissue. The surgical procedure of…”
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