Search Results - "SACHS, J. R"

Using Model‐Based “Learn and Confirm” to Reveal the Pharmacokinetics‐Pharmacodynamics Relationship of Pembrolizumab in the KEYNOTE‐001 Trial by Elassaiss‐Schaap, J, Rossenu, S, Lindauer, A, Kang, SP, de Greef, R, Sachs, JR, de Alwis, DP

“…Evaluation of pharmacokinetic/pharmacodynamic (PK/PD) properties played an important role in the early clinical development of pembrolizumab. Because analysis…”
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Dual-Energy Parathyroid 4D-CT: Improved Discrimination of Parathyroid Lesions from Thyroid Tissue Using Noncontrast 40-keV Virtual Monoenergetic Images by Bunch, P.M., Pavlina, A.A., Lipford, M.E., Sachs, J.R.

“…BACKGROUND AND PURPOSEIn parathyroid CT, a noncontrast phase aids discrimination of parathyroid lesions (not iodine-containing) from thyroid tissue…”
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Can Assessment of the Tongue on Brain MRI Aid Differentiation of Seizure from Alternative Causes of Transient Loss of Consciousness? by Erickson, J.A., Benayoun, M.D., Lack, C.M., Sachs, J.R., Bunch, P.M.

“…BACKGROUND AND PURPOSETransient loss of consciousness is commonly evaluated in the emergency department. Although typically caused by epileptic seizure,…”
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The Pharyngolaryngeal Venous Plexus: A Potential Pitfall in Surveillance Imaging of the Neck by Bunch, P M, Hughes, R T, White, E P, Sachs, J R, Frizzell, B A, Lack, C M

“…Among patients undergoing serial neck CTs, we have observed variability in the appearance of the pharyngolaryngeal venous plexus, which comprises the…”
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Internal Auditory Canal Diverticula among Pediatric Patients: Prevalence and Assessment for Hearing Loss and Anatomic Associations by Bunch, P M, Zapadka, M E, Lack, C M, Kiell, E P, Kirse, D J, Sachs, J R

“…Internal auditory canal diverticula are focal lucencies along the anterior-inferior aspect of the internal auditory canal fundus. Studies in adults report…”
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Soluble polycations and cationic amphiphiles inhibit volume-sensitive K-Cl cotransport in human red cell ghosts by Sachs, J R

“…We have measured the effect of soluble polycations (spermine and methylglyoxal) and cationic amphiphiles (sphingosine and tetracaine) on K-Cl cotransport in…”
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Sitagliptin 100 mg daily effect on DPP-4 inhibition and compound-specific glycemic improvement by Alba, M., Sheng, D., Guan, Y., Williams-Herman, D., Larson, P., Sachs, J.R., Thornberry, N., Herman, G., Kaufman, K.D., Goldstein, B.J.

“…Abstract Objective: In clinical trials, the degree of glucose lowering with sitagliptin has been correlated with the magnitude of dipeptidyl peptidase-4…”
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Interaction of magnesium with the sodium pump of the human red cell by Sachs, J R

“…1. In broken red cell membranes, Mg2+ inhibition of Na+,K+-adenosine-5'-triphosphatase (Na+,K+-ATPase) activity was partially competitive with MgATP. Mg2+…”
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Potassium-potassium exchange as part of the over-all reaction mechanism of the sodium pump of the human red blood cell by Sachs, J R

“…When the efflux components of the Na-K exchange and K-K exchange are measured under identical conditions, the apparent K 1/2 (the concentration of K at which…”
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Phosphate inhibition of the human red cell sodium pump: simultaneous binding of adenosine triphosphate and phosphate by Sachs, J R

“…1. The Na+-K+ exchange carried out by the Na+ pump of human red cell ghosts and the Na+ + K+-dependent adenosine triphosphatase (Na+,K+-ATPase) activity of…”
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The order of addition of sodium and release of potassium at the inside of the sodium pump of the human red cell by Sachs, J R

“…1. Inhibition of Na,K-adenosine 5'-triphosphatase (Na,K-ATPase) activity of human red cell membranes by vanadate rapidly reaches a steady-state level and is…”
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Cross-linking of the erythrocyte (Na+,K+)-ATPase. Chemical cross-linkers induce alpha-subunit-band 3 heterodimers and do not induce alpha-subunit homodimers by MARTIN, D. W, SACHS, J. R

“…Earlier studies (Periyasamy, S. M., Huang, W.-H., and Askari, A. (1983) J. Biol. Chem. 258, 9878-9885) suggested that Cu2+ and o-phenanthroline induced the…”
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The order of release of sodium and addition of potassium in the sodium-potassium pump reaction mechanism by Sachs, J R

“…1. The characteristics of oligomycin inhibition of the Na--K pump of human red cell membranes was investigated. Oligomycin inhibition of the pump was found to…”
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Ligands Presumed to Label High Affinity and Low Affinity ATP Binding Sites Do Not Interact in an (αβ)2 Diprotomer in Duck Nasal Gland Na+,K+-ATPase, nor Do the Sites Coexist in Native Enzyme by Martin, Dwight W., Sachs, John R.

“…The interaction of ligands deemed to be ATP analogues with renal Na+,K+-ATPase suggests that two ATP binding sites coexist on each functional unit. Previous…”
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Mechanistic implications of the potassium-potassium exchange carried out by the sodium-potassium pump by Sachs, J R

“…1. The magnitude of the K-K exchange carried out by the Na pump in human red cells was measured as a function of the external K concentration in cells with…”
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Kinetic evaluation of the Na-K pump reaction mechanism by Sachs, J R

“…1. The ouabain-sensitive K influx was measured at varying external K concentrations ([K]o) and at several fixed internal Na concentrations ([Na]c). The cells…”
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Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxide-dependent oxidations by ram seminal vesicle microsomes by Pagels, W R, Sachs, R J, Marnett, L J, Dewitt, D L, Day, J S, Smith, W L

“…Monoclonal antibodies against prostaglandin H (PGH) synthase have been used to precipitate cyclooxygenase and peroxidase activities from detergent-solubilized…”
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Perialveolar interstitial resistance and compliance in isolated rat lung by Pitt Ford, T R, Sachs, J R, Grotberg, J B, Glucksberg, M R

“…We have developed a method to characterize fluid transport through the perialveolar interstitium using micropuncture techniques. In 10 experiments we…”
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Kinetics of the inhibition of the Na-K pump by external sodium by Sachs, J R

“…1. When the ouabain-sensitive K influx or the ouabain-sensitive Cs influx is measured as a function of the extracellular concentration of K or Cs in Na-free…”
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Internal potassium stimulates the sodium-potassium pump by increasing cell ATP concentration by Sachs, J R

“…1. Intracellular K increases the ouabain-sensitive Na-K exchange in human red blood cells. Pump rate increases hyperbolically with internal K with a K12 for K…”
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