Search Results - "SACHS, Alan"

Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery by Shi, Bin, Keough, Ed, Matter, Andrea, Leander, Karen, Young, Stephanie, Carlini, Ed, Sachs, Alan B., Tao, Weikang, Abrams, Marc, Howell, Bonnie, Sepp-Lorenzino, Laura

“…Chemically stabilized small interfering RNA (siRNA) can be delivered systemically by intravenous injection of lipid nanoparticles (LNPs) in rodents and…”
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Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment by Abrams, Marc T, Koser, Martin L, Seitzer, Jessica, Williams, Stephanie C, DiPietro, Martha A, Wang, Weimin, Shaw, Andrew W, Mao, Xianzhi, Jadhav, Vasant, Davide, Joseph P, Burke, Paul A, Sachs, Alan B, Stirdivant, Steven M, Sepp-Lorenzino, Laura

“…Despite recent progress, systemic delivery remains the major hurdle for development of safe and effective small inhibitory RNA (siRNA)–based therapeutics…”
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High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer's Disease in Human Cerebrospinal Fluid by Hendrickson, Ronald C, Lee, Anita Y H, Song, Qinghua, Liaw, Andy, Wiener, Matt, Paweletz, Cloud P, Seeburger, Jeffrey L, Li, Jenny, Meng, Fanyu, Deyanova, Ekaterina G, Mazur, Matthew T, Settlage, Robert E, Zhao, Xuemei, Southwick, Katie, Du, Yi, Holder, Dan, Sachs, Jeffrey R, Laterza, Omar F, Dallob, Aimee, Chappell, Derek L, Snyder, Karen, Modur, Vijay, King, Elizabeth, Joachim, Catharine, Bondarenko, Andrey Y, Shearman, Mark, Soper, Keith A, Smith, A David, Potter, William Z, Koblan, Ken S, Sachs, Alan B, Yates, Nathan A

“…Disease modifying treatments for Alzheimer's disease (AD) constitute a major goal in medicine. Current trends suggest that biomarkers reflective of AD…”
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An integrative genomics approach to infer causal associations between gene expression and disease by Schadt, Eric E, Lamb, John, Yang, Xia, Zhu, Jun, Edwards, Steve, GuhaThakurta, Debraj, Sieberts, Solveig K, Monks, Stephanie, Reitman, Marc, Zhang, Chunsheng, Lum, Pek Yee, Leonardson, Amy, Thieringer, Rolf, Metzger, Joseph M, Yang, Liming, Castle, John, Zhu, Haoyuan, Kash, Shera F, Drake, Thomas A, Sachs, Alan, Lusis, Aldons J

“…A key goal of biomedical research is to elucidate the complex network of gene interactions underlying complex traits such as common human diseases. Here we…”
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Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses by Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura

“…A major hurdle for harnessing small interfering RNA (siRNA) for therapeutic application is an effective and safe delivery of siRNA to target tissues and cells…”
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Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E by Gross, John D., Moerke, Nathan J., von der Haar, Tobias, Lugovskoy, Alexey A., Sachs, Alan B., McCarthy, John E.G., Wagner, Gerhard

“…The eukaryotic initiation factor 4G (eIF4G) is the core of a multicomponent switch controlling gene expression at the level of translation initiation. It…”
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siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids[S] by Tadin-Strapps, Marija, Peterson, Laurence B., Cumiskey, Anne-Marie, Rosa, Raymond L., Mendoza, Vivienne Halili, Castro-Perez, Jose, Puig, Oscar, Zhang, Liwen, Strapps, Walter R., Yendluri, Satyasri, Andrews, Lori, Pickering, Victoria, Rice, Julie, Luo, Lily, Chen, Zhu, Tep, Samnang, Ason, Brandon, Somers, Elizabeth Polizzi, Sachs, Alan B., Bartz, Steven R., Tian, Jenny, Chin, Jayne, Hubbard, Brian K., Wong, Kenny K., Mitnaul, Lyndon J.

“…Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE–/– and low density…”
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MicroRNA-like off-target transcript regulation by siRNAs is species specific by Burchard, Julja, Jackson, Aimee L, Malkov, Vladislav, Needham, Rachel H V, Tan, Yejun, Bartz, Steven R, Dai, Hongyue, Sachs, Alan B, Linsley, Peter S

“…siRNAs mediate sequence-specific gene silencing in cultured mammalian cells but also silence unintended transcripts. Many siRNA off-target transcripts match…”
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Quantitative evaluation of siRNA delivery in vivo by Pei, Yi, Hancock, Paula J, Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J, Seitzer, Jessica, Koser, Martin L, Abrams, Marc T, Xu, Yan, Kuklin, Nelly A, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura, Barnett, Stanley F

“…Effective small interfering RNA (siRNA)-mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC)…”
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Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes by Sachs, Alan B, Sarnow, Peter, Hentze, Matthias W

“…In both prokaryotes and eukaryotes, ribosomes are recruited to mRNAs in a sequential, multistep process. In eukaryotes, following the recruitment of the small…”
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A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients by HONGYUE DAI, VAN'T VEER, Laura, STOUGHTON, Roland, FRIEND, Stephen, LAMB, John, HE, Yudong D, MAO MAO, FINE, Bernard M, BERNARDS, Rene, VAN DE VIJVER, Marc, DEUTSCH, Paul, SACHS, Alan

“…Breast cancer comprises a group of distinct subtypes that despite having similar histologic appearances, have very different metastatic potentials. Being able…”
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Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo by Kenski, Denise M, Cooper, Abby J, Li, Jenny J, Willingham, Aarron T, Haringsma, Henry J, Young, Tracy A, Kuklin, Nelly A, Jones, Jeffrey J, Cancilla, Mark T, McMasters, Daniel R, Mathur, Melina, Sachs, Alan B, Flanagan, W. Michael

“…Small interfering RNAs (siRNAs) are short, double-stranded RNAs that use the endogenous RNAi pathway to mediate gene silencing. Phosphorylation facilitates…”
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RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice by Wei, Jie, Jones, Jeffrey, Kang, Jing, Card, Ananda, Krimm, Michael, Hancock, Paula, Pei, Yi, Ason, Brandon, Payson, Elmer, Dubinina, Natalya, Cancilla, Mark, Stroh, Mark, Burchard, Julja, Sachs, Alan B, Hochman, Jerome H, Flanagan, W Michael, Kuklin, Nelly A

“…Deeper knowledge of pharmacokinetic and pharmacodynamic (PK/PD) concepts for RNA therapeutics is important to streamline the drug development process and for…”
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Glucose depletion rapidly inhibits translation initiation in yeast by Ashe, M P, De Long, S K, Sachs, A B

“…Glucose performs key functions as a signaling molecule in the yeast Saccharomyces cerevisiae. Glucose depletion is known to regulate gene expression via…”
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Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S] by Ason, Brandon, Tep, Samnang, Davis, Jr. Harry R., Xu, Yiming, Tetzloff, Glen, Galinski, Beverly, Soriano, Ferdie, Dubinina, Natalya, Zhu, Lei, Stefanni, Alice, Wong, Kenny K., Tadin-Strapps, Marija, Bartz, Steven R., Hubbard, Brian, Ranalletta, Mollie, Sachs, Alan B., Flanagan, W. Michael, Strack, Alison, Kuklin, Nelly A.

“…Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce…”
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LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease by Majercak, John, Ray, William J., Espeseth, Amy, Simon, Adam, Shi, Xiao-Ping, Wolffe, Carrie, Getty, Krista, Marine, Shane, Stec, Erica, Ferrer, Marc, Strulovici, Berta, Bartz, Steven, Gates, Adam, Xu, Min, Huang, Qian, Ma, Lei, Shughrue, Paul, Burchard, Julja, Colussi, Dennis, Pietrak, Beth, Kahana, Jason, Beher, Dirk, Rosahl, Thomas, Shearman, Mark, Hazuda, Daria, Sachs, Alan B., Koblan, Kenneth S., Seabrook, Guy R., Stone, David J.

“…Rare familial forms of Alzheimer's disease (AD) are thought to be caused by elevated proteolytic production of the Aβ42 peptide from the β-amyloid-precursor…”
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ApoB siRNA-induced Liver Steatosis is Resistant to Clearance by the Loss of Fatty Acid Transport Protein 5 (Fatp5) by Ason, Brandon, Castro-Perez, Jose, Tep, Samnang, Stefanni, Alice, Tadin-Strapps, Marija, Roddy, Thomas, Hankemeier, Thomas, Hubbard, Brian, Sachs, Alan B., Michael Flanagan, W., Kuklin, Nelly A., Mitnaul, Lyndon J.

“…The association between hypercholesterolemia and elevated serum apolipoprotein B (APOB) has generated interest in APOB as a therapeutic target for patients at…”
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Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels by Cervino, Alessandra C., Li, Guoya, Edwards, Steve, Zhu, Jun, Laurie, Cathy, Tokiwa, George, Lum, Pek Yee, Wang, Susanna, Castellini, Lawrence W., Lusis, Aldons J., Carlson, Sonia, Sachs, Alan B., Schadt, Eric E.

“…The use of inbred strains of mice to dissect the genetic complexity of common diseases offers a viable alternative to human studies, given the control over…”
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Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment by Simon, Jason S., Karnoub, Maha C., Devlin, David J., Arreaza, Maria G., Qiu, Ping, Monks, Stephanie A., Severino, Michael E., Deutsch, Paul, Palmisano, Joanne, Sachs, Alan B., Bayne, Marvin L., Plump, Andrew S., Schadt, Eric E.

“…Niemann-Pick C1-like 1 (NPC1L1) is an intestinal cholesterol transporter and the molecular target of ezetimibe, a cholesterol absorption inhibitor demonstrated…”
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Application of an End-to-End Biomarker Discovery Platform to Identify Target Engagement Markers in Cerebrospinal Fluid by High Resolution Differential Mass Spectrometry by Paweletz, Cloud P, Wiener, Matthew C, Bondarenko, Andrey Y, Yates, Nathan A, Song, Qinghua, Liaw, Andy, Lee, Anita Y. H, Hunt, Brandon T, Henle, Ernst S, Meng, Fanyu, Funk Sleph, Holly, Holahan, Marie, Sankaranarayanan, Sethu, Simon, Adam J, Settlage, Robert E, Sachs, Jeffrey R, Shearman, Mark, Sachs, Alan B, Cook, Jacquelynn J, Hendrickson, Ronald C

“…The rapid identification of protein biomarkers in biofluids is important to drug discovery and development. Here, we describe a general proteomic approach for…”
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