Search Results - "SACHINIDIS, A"

Induced pluripotent stem cells as a model for accelerated patient- and disease-specific drug discovery by Gunaseeli, I, Doss, M X, Antzelevitch, C, Hescheler, J, Sachinidis, A

“…Human induced pluripotent stem (iPS) cells hold great promise for therapy of a number of degenerative diseases such as ischemic heart failure, Parkinson's…”
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Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP by Krug, A K, Gutbier, S, Zhao, L, Pöltl, D, Kullmann, C, Ivanova, V, Förster, S, Jagtap, S, Meiser, J, Leparc, G, Schildknecht, S, Adam, M, Hiller, K, Farhan, H, Brunner, T, Hartung, T, Sachinidis, A, Leist, M

“…Assessment of the network of toxicity pathways by Omics technologies and bioinformatic data processing paves the road toward a new toxicology for the…”
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Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach by Krug, Anne K., Kolde, Raivo, Gaspar, John A., Rempel, Eugen, Balmer, Nina V., Meganathan, Kesavan, Vojnits, Kinga, Baquié, Mathurin, Waldmann, Tanja, Ensenat-Waser, Roberto, Jagtap, Smita, Evans, Richard M., Julien, Stephanie, Peterson, Hedi, Zagoura, Dimitra, Kadereit, Suzanne, Gerhard, Daniel, Sotiriadou, Isaia, Heke, Michael, Natarajan, Karthick, Henry, Margit, Winkler, Johannes, Marchan, Rosemarie, Stoppini, Luc, Bosgra, Sieto, Westerhout, Joost, Verwei, Miriam, Vilo, Jaak, Kortenkamp, Andreas, Hescheler, Jürgen, Hothorn, Ludwig, Bremer, Susanne, van Thriel, Christoph, Krause, Karl-Heinz, Hengstler, Jan G., Rahnenführer, Jörg, Leist, Marcel, Sachinidis, Agapios

“…Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based…”
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Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells by Meganathan, K, Jagtap, S, Srinivasan, S P, Wagh, V, Hescheler, J, Hengstler, J, Leist, M, Sachinidis, A

“…Human embryonic stem cells (hESCs) may be applied to develop human-relevant sensitive in vitro test systems for monitoring developmental toxicants. The aim of…”
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Differences in the Early Development of Human and Mouse Embryonic Stem Cells by Gabdoulline, R, Kaisers, W, Gaspar, A, Meganathan, K, Doss, M X, Jagtap, S, Hescheler, J, Sachinidis, A, Schwender, H

“…We performed a systematic analysis of gene expression features in early (10-21 days) development of human vs mouse embryonic cells (hESCs vs mESCs). Many…”
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Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery by Zimmer, B., Pallocca, G., Dreser, N., Foerster, S., Waldmann, T., Westerhout, J., Julien, S., Krause, K. H., van Thriel, C., Hengstler, J. G., Sachinidis, A., Bosgra, S., Leist, M.

“…Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem…”
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Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation by Jagtap, S, Meganathan, K, Gaspar, J, Wagh, V, Winkler, J, Hescheler, J, Sachinidis, A

“…BACKGROUND AND PURPOSE Teratogenic substances induce adverse effects during the development of the embryo. Multilineage differentiation of human embryonic stem…”
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Characterisation of a neural teratogenicity assay based on human ESCs differentiation following exposure to valproic acid by Colleoni, S, Galli, C, Gaspar, J A, Meganathan, K, Jagtap, S, Hescheler, J, Sachinidis, A, Lazzari, G

“…The development of in vitro testing strategies for chemical and drug screening is a priority need in order to protect human health, to increase safety, to…”
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The potential of embryonic stem cells combined with -omics technologies as model systems for toxicology by Winkler, J, Sotiriadou, I, Chen, S, Hescheler, J, Sachinidis, A

“…The derivation of pluripotent embryonic stem (ES) cell lines has opened up new areas of research in basic and applied science, most significantly in…”
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Fam40b is required for lineage commitment of murine embryonic stem cells by Wagh, V, Doss, M X, Sabour, D, Niemann, R, Meganathan, K, Jagtap, S, Gaspar, J A, Ardestani, M A, Papadopoulos, S, Gajewski, M, Winkler, J, Hescheler, J, Sachinidis, A

“…FAM40B (STRIP2) is a member of the striatin-interacting phosphatase and kinase (STRIPAK) complex that is involved in the regulation of various processes such…”
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A method for the rapid construction of cRNA standard curves in quantitative real-time reverse transcription polymerase chain reaction by Fronhoffs, S., Totzke, G., Stier, S., Wernert, N., Rothe, M., Brüning, T., Koch, B., Sachinidis, A., Vetter, H., Ko, Y.

“…Quantification of nucleic acids, especially of mRNA, is increasingly important in biomedical research. The recently developed quantitative real-time polymerase…”
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A liver-derived rat epithelial cell line from biliary origin acquires hepatic functions upon sequential exposure to hepatogenic growth factors and cytokines by De Kock, J, Snykers, S, Branson, S, Jagtap, S, Gaspar, J A, Sachinidis, A, Vanhaecke, T, Rogiers, V

“…Withdrawal of promising drug candidates is often due to the detection of liver toxicity. In particular the parenchymal liver cells or hepatocytes are targeted…”
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Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells by Lucendo-Villarin, B, Nell, P, Hellwig, B, Filis, P, Feuerborn, D, O'Shaughnessy, P J, Godoy, P, Rahnenführer, J, Hengstler, J G, Cherianidou, A, Sachinidis, A, Fowler, P A, Hay, D C

“…The debate about possible adverse effects of bisphenol A (BPA) has been ongoing for decades. Bisphenol F (BPF) and S (BPS) have been suggested as "safer"…”
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A tanscriptomics study to elucidate the toxicological mechanism of methylmercury chloride in a human stem cell based in vitro test by Vojnits, K, Ensenat-Waser, R, Gaspar, J A, Meganathan, K, Jagtap, S, Hescheler, J, Sachinidis, A, Bremer-Hoffmann, S

“…Traditional approaches in evaluating the hazard of drug candidates on the developing offspring are often time-consuming and cost-intensive. Moreover,…”
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Effective surface-based cryopreservation of human embryonic stem cells by vitrification by Beier, A.F.J., Schulz, J.C., Dörr, D., Katsen-Globa, A., Sachinidis, A., Hescheler, J., Zimmermann, H.

“…► We established a surface-based protocol for bulk vitrification of hESCs. ► It results in very high recovery rates and maintains pluripotency. ► Method is…”
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Upregulation of vascular angiotensin II receptor gene expression by low-density lipoprotein in vascular smooth muscle cells by NICKENING, G, SACHINIDIS, A, MICHAELSEN, F, BÖHM, M, SEEWALD, S, VETTER, H

“…Because LDL and the angiotensin II type 1 (AT1) receptor are thought to be involved in the pathogenesis of chronic vascular disease, we studied possible…”
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Molecular mechanisms explaining the preventive effects of catechins on the development of proliferative diseases by Gouni-Berthold, I, Sachinidis, A

“…Various growth factors such as the platelet derived growth factor (PDGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), fibroblast growth…”
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Derivation of es Cells From Early Stage Preimplantation Embryos and Characterisation of their Cardiac Differentiation Potential in Mice by Bag, S, Pfannkuche, K, Krzyzak, V, Wagner, B, Sachinidis, A, Hescheler, J

“…Most murine embryonic stem cell lines have been derived from the inner cell mass of blastocysts and extensively studied in different aspects including…”
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Limitations of the reverse transcription-polymerase chain reaction method for the detection of carcinoembryonic antigen-positive tumor cells in peripheral blood by YON KO, KLINZ, M, TOTZKE, G, GOUNI-BERTHOLD, I, SACHINIDIS, A, VETTER, H

“…To examine the limitations of reverse transcription (RT)-PCR for the detection of circulating tumor cells in blood, we established a RT-PCR for…”
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THE ASSOCIATION OF EGFR AND ALBUMINURIA WITH SYSTOLIC HYPERTENSION IN PATIENTS WITH DIABETES by Georgianou, E., Markakis, K., Georgianos, P., Zografou, I., Sachinidis, A., Sabanis, C., Doumas, M.

“…Objective: Large epidemiological studies have shown that the prevalence of hypertension increases in parallel with the staging of chronic kidney disease…”
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