Search Results - "SACHAN, Nita"
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FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
Published in Proceedings of the National Academy of Sciences - PNAS (18-12-2007)“…Insulin resistance and metabolic syndrome are rapidly expanding public health problems. Acting through the PI3K/Akt pathway, insulin and insulin-like growth…”
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2
Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling
Published in Circulation (New York, N.Y.) (12-09-2006)“…Cellular hypertrophy requires coordinated regulation of progrowth and antigrowth mechanisms. In cultured neonatal cardiomyocytes, Foxo transcription factors…”
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3
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo
Published in PLoS genetics (01-05-2012)“…Defects of atrial and ventricular septation are the most frequent form of congenital heart disease, accounting for almost 50% of all cases. We previously…”
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4
The Down Syndrome Critical Region Protein RCAN1 Regulates Long-Term Potentiation and Memory via Inhibition of Phosphatase Signaling
Published in The Journal of neuroscience (28-11-2007)“…Regulator of calcineurin 1 (RCAN1/MCIP1/DSCR1) regulates the calmodulin-dependent phosphatase calcineurin. Because it is located on human chromosome 21, RCAN1…”
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5
Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion
Published in Journal of molecular and cellular cardiology (01-09-2014)“…Abstract Many important components of the cardiovascular system display circadian rhythmicity. In both humans and mice, cardiac damage from…”
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Abstract P275: Time-of-Day--Dependent Variation in Myocardial Ischemia/Reperfusion Injury Is Lost in Mice Lacking the Regulator of Calcineurin 1 Gene
Published in Circulation research (09-12-2011)“…Abstract only Many important components of the cardiovascular system display circadian rhythmicity. In humans, the incidence of myocardial infarction peaks in…”
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Sustained Hemodynamic Stress Disrupts Normal Circadian Rhythms in Calcineurin-Dependent Signaling and Protein Phosphorylation in the Heart
Published in Circulation research (18-02-2011)“…RATIONALE:Despite overwhelming evidence of the importance of circadian rhythms in cardiovascular health and disease, little is known regarding the circadian…”
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8
Reactive oxygen species regulate alkaloid metabolism in undifferentiated N. tabacum cells
Published in Plant cell reports (01-05-2010)“…Plants produce an immense number of natural products and undifferentiated cells from various plant tissues have long been considered an ideal source for their…”
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Abstract 3442: Normal Circadian Rhythms In Calcineurin-dependent Signaling And Protein Phosphorylation Are Disrupted In Heart Failure
Published in Circulation (New York, N.Y.) (28-10-2008)“…Abstract only Many important cardiovascular factors, including metabolism, heart rate, blood pressure, and hormone release, oscillate over a 24-hour period. In…”
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10
Wound-induced gene expression of putrescine N-methyltransferase in leaves of Nicotiana tabacum
Published in Phytochemistry (Oxford) (01-12-2002)“…Putrescine N-methyltransferase (PMT) catalyzes the first committed step in the biosynthesis of pyrrolinium ring-containing alkaloids. Earlier studies have…”
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