Search Results - "SACCI, John"

Transfer Hydrogenation in Water via a Ruthenium Catalyst with OH Groups near the Metal Center on a bipy Scaffold by Nieto, Ismael, Livings, Michelle S, Sacci, John B, Reuther, Lauren E, Zeller, Matthias, Papish, Elizabeth T

“…The new ligand 6,6′-dihydroxy-2,2′-bipyridyl (dhbp) was synthesized via its tautomer, and this provides an efficient route to novel metal complexes of dhbp. In…”
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Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development by Aguiar, Joao C, Bolton, Jessica, Wanga, Joyce, Sacci, John B, Iriko, Hideyuki, Mazeika, Julie K, Han, Eun-Taek, Limbach, Keith, Patterson, Noelle B, Sedegah, Martha, Cruz, Ann-Marie, Tsuboi, Takafumi, Hoffman, Stephen L, Carucci, Daniel, Hollingdale, Michael R, Villasante, Eileen D, Richie, Thomas L

“…Nearly 100% protection against malaria infection can be achieved in humans by immunization with P. falciparum radiation-attenuated sporozoites (RAS). Although…”
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Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design by VanBuskirk, Kelley M, O'Neill, Matthew T, De La Vega, Patricia, Maier, Alexander G, Krzych, Urszula, Williams, Jack, Dowler, Megan G, Sacci, John B. Jr, Kangwanrangsan, Niwat, Tsuboi, Takafumi, Kneteman, Norman M, Heppner, Donald G. Jr, Murdock, Brant A, Mikolajczak, Sebastian A, Aly, Ahmed S.I, Cowman, Alan F, Kappe, Stefan H.I

“…Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium sporozoite stage during a blood meal. Irradiated sporozoites confer sterile…”
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Novel malaria antigen Plasmodium yoelii E140 induces antibody-mediated sterile protection in mice against malaria challenge by Smith, Emily C, Limbach, Keith J, Rangel, Nonenipha, Oda, Kyosuke, Bolton, Jessica S, Du, Mengyan, Gowda, Kalpana, Wang, Jianyang, Moch, J Kathleen, Sonawane, Sharvari, Velasco, Rachel, Belmonte, Arnel, Danner, Rebecca, Lumsden, Joanne M, Patterson, Noelle B, Sedegah, Martha, Hollingdale, Michael R, Richie, Thomas L, Sacci, Jr, John B, Villasante, Eileen D, Aguiar, Joao C

“…Only a small fraction of the antigens expressed by malaria parasites have been evaluated as vaccine candidates. A successful malaria subunit vaccine will…”
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CD8 + T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes by Chakravarty, Sumana, Cockburn, Ian A, Sacci, John B, Overstreet, Michael G, Zavala, Fidel, Kuk, Salih

“…The success of immunization with irradiated sporozoites is unparalleled among the current vaccination approaches against malaria, but its mechanistic…”
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Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites by Voss, Christiane, Ehrenman, Karen, Mlambo, Godfree, Mishra, Satish, Kumar, Kota Arun, Sacci, Jr, John B, Sinnis, Photini, Coppens, Isabelle

“…Plasmodium parasites undergo continuous cellular renovation to adapt to various environments in the vertebrate host and insect vector. In hepatocytes,…”
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Cellular immune response to DNA and vaccinia prime-boost immunization kills Plasmodium yoelii-infected hepatocytes in vitro by Sacci, Jr, John B, Hollingdale, Michael R, Sedegah, Martha

“…Plasmid DNA encoding Plasmodium yoelii circumsporozoite protein (PyCSP) followed by boosting with recombinant vaccinia virus containing the PyCSP elicited…”
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A proteomic view of the Plasmodium falciparum life cycle by Yates, John R, Florens, Laurence, Washburn, Michael P, Raine, J. Dale, Anthony, Robert M, Grainger, Munira, Haynes, J. David, Moch, J. Kathleen, Muster, Nemone, Sacci, John B, Tabb, David L, Witney, Adam A, Wolters, Dirk, Wu, Yimin, Gardner, Malcolm J, Holder, Anthony A, Sinden, Robert E, Carucci, Daniel J

“…The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here,…”
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Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity by Hickey, Bradley W, Lumsden, Joanne M, Reyes, Sharina, Sedegah, Martha, Hollingdale, Michael R, Freilich, Daniel A, Luke, Thomas C, Charoenvit, Yupin, Goh, Lucy M, Berzins, Mara P, Bebris, Lolita, Sacci, Jr, John B, De La Vega, Patricia, Wang, Ruobing, Ganeshan, Harini, Abot, Esteban N, Carucci, Daniel J, Doolan, Denise L, Brice, Gary T, Kumar, Anita, Aguiar, Joao, Nutman, Thomas B, Leitman, Susan F, Hoffman, Stephen L, Epstein, Judith E, Richie, Thomas L

“…In this phase 1 clinical trial, healthy adult, malaria-naïve subjects were immunized with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) by…”
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Plasmodium falciparum PF10_0164 (ETRAMP10.3) Is an Essential Parasitophorous Vacuole and Exported Protein in Blood Stages by Mackellar, Drew C, O'Neill, Matthew T, Aly, Ahmed S I, Sacci, John B, Cowman, Alan F, Kappe, Stefan H I

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Disruption of the Plasmodium falciparum liver‐stage antigen‐1 locus causes a differentiation defect in late liver‐stage parasites by Mikolajczak, Sebastian A., Sacci, Jr, John B., De La Vega, Patricia, Camargo, Nelly, VanBuskirk, Kelly, Krzych, Urszula, Cao, Jun, Jacobs‐Lorena, Marcelo, Cowman, Alan F., Kappe, Stefan H. I.

“…Summary The malaria parasite Plasmodium falciparum infects humans and first targets the liver where liver‐stage parasites undergo pre‐erythrocytic replication…”
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A full-length Plasmodium falciparum recombinant circumsporozoite protein expressed by Pseudomonas fluorescens platform as a malaria vaccine candidate by Noe, Amy R, Espinosa, Diego, Li, Xiangming, Coelho-Dos-Reis, Jordana G A, Funakoshi, Ryota, Giardina, Steve, Jin, Hongfan, Retallack, Diane M, Haverstock, Ryan, Allen, Jeffrey R, Vedvick, Thomas S, Fox, Christopher B, Reed, Steven G, Ayala, Ramses, Roberts, Brian, Winram, Scott B, Sacci, John, Tsuji, Moriya, Zavala, Fidel, Gutierrez, Gabriel M

“…The circumsporozoite protein (CSP) of Plasmodium falciparum is a major surface protein, which forms a dense coat on the sporozoite's surface. Preclinical…”
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Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates by Limbach, Keith, Aguiar, Joao, Gowda, Kalpana, Patterson, Noelle, Abot, Esteban, Sedegah, Martha, Sacci, John, Richie, Thomas

“…Despite years of effort, a licensed malaria vaccine is not yet available. One of the obstacles facing the development of a malaria vaccine is the extensive…”
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Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers by Sacci, John B., Alam, Uzma, Douglas, Donna, Lewis, Jamie, Tyrrell, D Lorne J., Azad, Abdu F., Kneteman, Norman M.

“…The exoerythrocytic stage of Plasmodium falciparum has remained a difficult phase of the parasite life-cycle to study. The host and tissue specificity of the…”
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Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA by Richie, Thomas L., Charoenvit, Yupin, Wang, Ruobing, Epstein, Judith E., Hedstrom, Richard C., Kumar, Sanjai, Luke, Thomas C., Freilich, Daniel A., Aguiar, Joao C., Sacci, Jr, John B., Sedegah, Martha, Nosek, Jr, Ronald A., De La Vega, Patricia, Berzins, Mara P., Majam, Victoria F., Abot, Esteban N., Ganeshan, Harini, Richie, Nancy O., Banania, Jo Glenna, Baraceros, Maria Fe B., Geter, Tanya G., Mere, Robin, Bebris, Lolita, Limbach, Keith, Hickey, Bradley W., Lanar, David E., Ng, Jennifer, Shi, Meng, Hobart, Peter M., Norman, Jon A., Soisson, Lorraine A., Hollingdale, Michael R., Rogers, William O., Doolan, Denise L., Hoffman, Stephen L.

“…When introduced in the 1990s, immunization with DNA plasmids was considered potentially revolutionary for vaccine development, particularly for vaccines…”
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Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals by Nguyen, Thanh V, Sacci, Jr, John B, de la Vega, Patricia, John, Chandy C, James, Anthony A, Kang, Angray S

“…MB2 protein is a sporozoite surface antigen on the human malaria parasite Plasmodium falciparum. MB2 was identified by screening a P. falciparum sporozoite…”
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High-throughput generation of P. falciparum functional molecules by recombinational cloning by Aguiar, João Carlos, LaBaer, Joshua, Blair, Peter L, Shamailova, Victoria Y, Koundinya, Malvika, Russell, Joshua A, Huang, Fengying, Mar, Wenhong, Anthony, Robert M, Witney, Adam, Caruana, Sonia R, Brizuela, Leonardo, Sacci, Jr, John B, Hoffman, Stephen L, Carucci, Daniel J

“…Large-scale functional genomics studies for malaria vaccine and drug development will depend on the generation of molecular tools to study protein expression…”
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Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase by Nicoll, William S, Sacci, John B, Rodolfo, Carlo, Di Giacomo, Giuseppina, Piacentini, Mauro, Holland, Zoe Jm, Doerig, Christian, Hollingdale, Michael R, Lanar, David E

“…Plasmodium falciparum sporozoites injected by mosquitoes into the blood rapidly enter liver hepatocytes and undergo pre-erythrocytic developmental schizogony…”
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Monoclonal Antibody MG96 Completely Blocks Plasmodium yoelii Development in Anopheles stephensi by DINGLASAN, Rhoel R, FIELDS, Iesha, SHAHABUDDIN, Mohammed, AZAD, Abdu F, SACCI, John B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Functional immunoassays using an in-vitro malaria liver-stage infection model: where do we go from here? by House, Brent L, Hollingdale, Michael R, Sacci, John B, Richie, Thomas L

“…For more than 25 years, the ISI assay and ILSDA have been used to study the development of the malaria parasite in the liver, to discover and characterize…”
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