Search Results - "SABBAGH, I"

Synthesis and antiviral activity of new pyrazole and thiazole derivatives by El-Sabbagh, Osama I., Baraka, Mohamed M., Ibrahim, Samy M., Pannecouque, Christophe, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Rashad, Adel A.

“…New N-acetyl ( 5– 8) and N-thiocarbamoyl ( 9– 12) derivatives of 4,5-dihydropyrazole were synthesized starting from α,β-unsaturated ketones under the effect of…”
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Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors by Salem, Ibrahim M., Mostafa, Samia M., Salama, Ismail, El-Sabbagh, Osama I., Hegazy, Wael A. H., Ibrahim, Tarek S.

“…The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel…”
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The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme by Malebari, Azizah M., Ibrahim, Tarek S., Salem, Ibrahim M., Salama, Ismail, Khayyat, Ahdab N., Mostafa, Samia M., El-Sabbagh, Osama I., Darwish, Khaled M.

“…The membrane-bound human carbonic anhydrase (hCA) IX is widely recognized as a marker of tumor hypoxia and a prognostic factor within several human cancers…”
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Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium by El-Sabbagh, Osama I.

“…Two new series of benzenesulfonamide (4a–f, 5a–b, 6, 7) and 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide (9a–c, 10, 12a–d) derivatives were prepared starting from…”
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Effect of microstructural changes on thermal, electrical, and mechanical properties of HDPE reinforced by sisal fibers by Abou-Kandil, Ahmed I, Shehata, AB, Yousef, E, El-Sabbagh, I, Salem, K

“…Chemically modified sisal fibers are used to reinforce high-density polyethylene to seek applications in electrical appliances and car industry requiring light…”
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New thiopyridine complexes: design, electrochemical preparation and biological assessment by El-Sabbagh, Osama I., Yamany, Yamany B., Eldeab, Hany A.

“…Novel complexes of Ru (III), Cu (II) and Au (III) ( ) were prepared using 6-phenyl-2-thioxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (HL, )…”
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New octahydroquinazoline derivatives: Synthesis and hypotensive activity by El-Sabbagh, O.I., Shabaan, Mohamed A., Kadry, Hanan H., Al-Din, Ehab Saad

“…Several novel 1-(4-chlorophenyl)-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydro-5-oxo-3-(substitutedphenyl)quinazoline derivatives ( 2– 21) structurally similar to…”
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Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation by El-Sabbagh, Osama I., Ibrahim, Samy M., Baraka, Mohamed M., Kothayer, Hend

“…Starting from isatoic anhydrides, several new 2,3‐dihydroquinazolin‐4(1H)‐one derivatives bearing chalcone or pyrazole or thiazole moieties at the third…”
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Synthesis and Biological Evaluation of Some N-Arylpyrazoles and Pyrazolo[3,4-d]pyridazines as Anti-Inflammatory Agents by El-Sabbagh, Osama I., Mostafa, Samia, Abdel-Aziz, Hatem A., Ibrahim, Hany S., Elaasser, Mahmoud M.

“…A series of 3,4‐bis‐chalcone‐N‐arylpyrazoles 3a–k was prepared from diacetyl pyrazoles 2a–e. The reaction of 2d and 2e with hydrazine hydrate gave…”
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Forecasting and visualization of wildfires in a 3D geographical information system by Castrillón, M., Jorge, P.A., López, I.J., Macías, A., Martín, D., Nebot, R.J., Sabbagh, I., Quintana, F.M., Sánchez, J., Sánchez, A.J., Suárez, J.P., Trujillo, A.

“…This paper describes a wildfire forecasting application based on a 3D virtual environment and a fire simulation engine. A novel open-source framework is…”
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Synthesis of New Nonclassical Acridines, Quinolines, and Quinazolines Derived from Dimedone for Biological Evaluation by Sabbagh, Osama I. El, Shabaan, Mohamed A., Kadry, Hanan H., Al-Din, Ehab Saad

“…New nonclassical acridines, quinolines, and quinazolines were prepared starting from cyclic β‐diketones, namely dimedone, through application of Hantzsch…”
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Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines by Abdelkhalek, Ahmed S., Kothayer, Hend, Rezq, Samar, Orabi, Khaled Y., Romero, Damian G., El-Sabbagh, Osama I.

“…A new series of thieno[2,3-d]pyrimidine derivatives 4, 5, 6a-o, and 11 was designed and synthesized starting from cyclohexanone under Gewald condition with the…”
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Seasonality of top-down control of bacterioplankton at two central Red Sea sites with different trophic status by Sabbagh, Eman I, Calleja, Maria Ll, Daffonchio, Daniele, Morán, Xosé Anxelu G

“…The role of bottom-up (nutrient availability) and top-down (grazers and viruses mortality) controls on tropical bacterioplankton have been rarely investigated…”
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Synthesis of new acridines and hydrazones derived from cyclic β-diketone for cytotoxic and antiviral evaluation by El-Sabbagh, Osama I., Rady, Hanaa M.

“…Cyclic β-diketone namely, dimedone was utilized to prepare different chemical entities whether cyclic such as acridines, thiadiazole and triazole or acyclic…”
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Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors by Taher, Ehab S., Ibrahim, Tarek S., Fares, Mohamed, AL-Mahmoudy, Amany M.M., Radwan, Abdullah F., Orabi, Khaled Y., El-Sabbagh, Osama I.

“…Two new series of 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives containing either five membered heterocyclic rings or aryl hydrazones were synthesized…”
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Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo[3,4–d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study by Salem, Ibrahim M., Mostafa, Samia M., Salama, Ismail, El-Sabbagh, Osama I., A. H. Hegazy, Wael, Ibrahim, Tarek S.

“…[Display omitted] •Novel pyrazolo[3,4–d]pyrimidine derivatives structurally similar with the classical MTX and MTX related antifolates were synthesized as…”
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Ionic distribution and polymer conformation, near phase separation, in sodium polyacrylate/divalent cations mixtures : small angle X-ray and neutron scattering by SABBAGH, I, DELSANTI, M, LESIEUR, P

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Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold by Ibrahim, Tarek S., Salem, Ibrahim M., Mostafa, Samia M., El-Sabbagh, Osama I., ElKhamisi, Mohamed K.M., Hegazy, Lamees, Elgendy, Bahaa

“…[Display omitted] •Novel and selective COX-2 inhibitors based on bumetanide scaffold were developed.•Compounds 6b, 9a, and 9c were more potent than…”
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Synthesis, DNA Binding and Antiviral Activity of New Uracil, Xanthine, and Pteridine Derivatives by El-Sabbagh, Osama I., El-Sadek, Mohamed E., El-Kalyoubi, Samar, Ismail, Ibrahim

“…Some new 6‐amino‐1,3‐dimethyl‐5‐(substituted methylidene)aminouracils were synthesized. Most of them were cyclized with triethyl orthoformate as a one‐carbon…”
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Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides by Kothayer, Hend, Elshanawani, Abdalla A., Abu Kull, Mansour E., El-Sabbagh, Osama I., Shekhar, Malathy P.V., Brancale, Andrea, Jones, Arwyn T., Westwell, Andrew D.

“…Series of substituted 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides have been synthesised, based on molecular modelling of candidate…”
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