Search Results - "SAAVEDRA, JUAN M"

Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer’s Disease by Saavedra, Juan M.

“…Alzheimer’s disease is the most frequent type of dementia and diagnosed late in the progression of the illness when irreversible brain tissue loss has already…”
Get full text

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization by Wang, Yunjie, Huang, Yun, Xu, Yazhou, Ruan, Wenchen, Wang, Haojie, Zhang, Yihua, Saavedra, Juan M, Zhang, Luyong, Huang, Zhangjian, Pang, Tao

“…Microglia-mediated neuroinflammation plays an important role in focal ischemic stroke, a disorder with no effective therapeutic agents. Since microglial…”
Get more information

Candesartan could ameliorate the COVID-19 cytokine storm by Elkahloun, Abdel G., Saavedra, Juan M.

“…[Display omitted] •Candesartan downregulates expression of many glutamate upregulated genes in cultured neurons.•Glutamate upregulated genes in neurons…”
Get full text

Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications by Saavedra, Juan M, Sánchez-Lemus, Enrique, Benicky, Julius

“…Summary Poor adaptation to stress, alterations in cerebrovascular function and excessive brain inflammation play critical roles in the pathophysiology of many…”
Get full text

Trace Amines and Trace Amine-Associated Receptors: A New Frontier in Cell Signaling by Freyberg, Zachary, Saavedra, Juan M.

“…Trace amines, including β-phenylethylamine, p -octopamine, p -tyramine, and tryptamine, are produced in high levels in invertebrates where they play major…”
Get full text

Angiotensin II AT1 receptor blockade ameliorates brain inflammation by Benicky, Julius, Sánchez-Lemus, Enrique, Honda, Masaru, Pang, Tao, Orecna, Martina, Wang, Juan, Leng, Yan, Chuang, De-Maw, Saavedra, Juan M

“…Brain inflammation has a critical role in the pathophysiology of brain diseases of high prevalence and economic impact, such as major depression,…”
Get full text

Commercially available angiotensin II At₂ receptor antibodies are nonspecific by Hafko, Roman, Villapol, Sonia, Nostramo, Regina, Symes, Aviva, Sabban, Esther L, Inagami, Tadashi, Saavedra, Juan M

“…Commercially available angiotensin II At₂ receptor antibodies are widely employed for receptor localization and quantification, but they have not been…”
Get full text

Six Commercially Available Angiotensin II AT1 Receptor Antibodies are Non-specific by Benicky, Julius, Hafko, Roman, Sanchez-Lemus, Enrique, Aguilera, Greti, Saavedra, Juan M.

“…Commercially available Angiotensin II AT 1 receptor antibodies are widely employed for receptor localization and quantification, but they have not been…”
Get full text

Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction by Gao, Yuanxue, Xu, Xiaojun, Chang, Sai, Wang, Yunjie, Xu, Yazhou, Ran, Siqi, Huang, Zhangjian, Li, Ping, Li, Jia, Zhang, Luyong, Saavedra, Juan M., Liao, Hong, Pang, Tao

“…The natural product totarol, a phenolic diterpenoid and a major constituent isolated from the sap of Podocarpus totara, has been reported to have a potent…”
Get full text

Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition by Pang, Tao, Wang, Juan, Benicky, Julius, Saavedra, Juan M.

“…Minocycline exhibits anti-inflammatory properties independent of its antibiotic activity, ameliorating inflammatory responses in monocytes and macrophages…”
Get full text

Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways by Pang, Tao, Wang, Juan, Benicky, Julius, Sánchez-Lemus, Enrique, Saavedra, Juan M

“…Blockade of angiotensin II type 1 (AT1) receptors ameliorates brain inflammation, and reduces excessive brain interleukin-1 beta (IL-1β) production and release…”
Get full text

Angiotensin receptor blockers and COVID-19 by Saavedra, Juan M.

“…Angiotensin Receptor Blockers (ARBs) exhibit major pleiotropic protecting effects beyond their antihypertensive properties, including reduction of…”
Get full text

Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery by Benicky, Julius, Sánchez-Lemus, Enrique, Pavel, Jaroslav, Saavedra, Juan M

“…In addition to regulating blood pressure, Angiotensin II (Ang II) exerts powerful pro-inflammatory effects in hypertension through stimulation of its AT₁…”
Get full text

Brain and peripheral angiotensin II play a major role in stress by Saavedra, Juan M, Benicky, Julius

“…Angiotensin II (Ang II), the active principle of the renin-angiotensin system (RAS), was discovered as a vasoconstrictive, fluid retentive circulating hormone…”
Get more information

Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders by Saavedra, Juan M

“…The effects of brain AngII (angiotensin II) depend on AT(1) receptor (AngII type 1 receptor) stimulation and include regulation of cerebrovascular flow,…”
Get more information

Angiotensin Receptor Blockers Are Not Just for Hypertension Anymore by Saavedra, Juan M

“…Beyond blood pressure control, angiotensin receptor blockers reduce common injury mechanisms, decreasing excessive inflammation and protecting endothelial and…”
Get full text

COVID-19, Angiotensin Receptor Blockers, and the Brain by Saavedra, Juan M.

Get full text

Neuroprotective Effects of Angiotensin Receptor Blockers by Villapol, Sonia, Saavedra, Juan M.

“…Angiotensin II receptor blockers (ARBs, collectively called sartans) are widely used compounds therapeutically effective in cardiovascular disorders, renal…”
Get full text

543 The link between preexisting hypertension and COVID-19 severity in a hamster model by Stanic, Branka, Hawks, Seth, Shults, Nataliia, Ji, Hong, de Souza, Aline M.A., Wu, Xie, Saavedra, Juan M., Sandberg, Kathryn, Duggal, Nisha

“…OBJECTIVES/GOALS: Hypertension is a major risk factor for coronavirus disease 2019 (COVID-19) severity. Our goal was to determine if hypertension worsens lung…”
Get full text

Angiotensin II AT1 Receptor Blockade Abolishes Brain Microvascular Inflammation and Heat Shock Protein Responses in Hypertensive Rats by Zhou, Jin, Ando, Hiromichi, Macova, Miroslava, Dou, Jingtao, Saavedra, Juan M

“…Endothelial dysfunction and inflammation enhance vulnerability to hypertensive brain damage. To explore the participation of Angiotensin II (Ang II) in the…”
Get full text