Search Results - "S. Sawicki"

The mechanics and energetics of human walking and running: a joint level perspective by Farris, Dominic James, Sawicki, Gregory S.

“…Humans walk and run at a range of speeds. While steady locomotion at a given speed requires no net mechanical work, moving faster does demand both more…”
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Reducing the energy cost of human walking using an unpowered exoskeleton by Collins, Steven H., Wiggin, M. Bruce, Sawicki, Gregory S.

“…With efficiencies derived from evolution, growth and learning, humans are very well-tuned for locomotion 1 . Metabolic energy used during walking can be partly…”
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The exoskeleton expansion: improving walking and running economy by Sawicki, Gregory S, Beck, Owen N, Kang, Inseung, Young, Aaron J

“…Since the early 2000s, researchers have been trying to develop lower-limb exoskeletons that augment human mobility by reducing the metabolic cost of walking…”
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Human medial gastrocnemius force–velocity behavior shifts with locomotion speed and gait by Farris, Dominic James, Sawicki, Gregory S

“…Humans walk and run over a wide range of speeds with remarkable efficiency. For steady locomotion, moving at different speeds requires the muscle–tendon units…”
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Mechanics of walking and running up and downhill: A joint-level perspective to guide design of lower-limb exoskeletons by Nuckols, Richard W, Takahashi, Kota Z, Farris, Dominic J, Mizrachi, Sarai, Riemer, Raziel, Sawicki, Gregory S

“…Lower-limb wearable robotic devices can improve clinical gait and reduce energetic demand in healthy populations. To help enable real-world use, we sought to…”
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Estimation of quasi-stiffness and propulsive work of the human ankle in the stance phase of walking by Shamaei, Kamran, Sawicki, Gregory S, Dollar, Aaron M

“…Characterizing the quasi-stiffness and work of lower extremity joints is critical for evaluating human locomotion and designing assistive devices such as…”
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Trailing limb angle is a surrogate for propulsive limb forces during walking post-stroke by Lewek, Michael D., Sawicki, Gregory S.

“…Propulsive deficits following stroke have been attributed to reduced plantarflexion moments and a reduced trailing limb angle. We sought to determine the…”
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Impact of elastic ankle exoskeleton stiffness on neuromechanics and energetics of human walking across multiple speeds by Nuckols, Richard W, Sawicki, Gregory S

“…Elastic ankle exoskeletons with intermediate stiffness springs in parallel with the human plantarflexors can reduce the metabolic cost of walking by ~ 7% at…”
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Estimation of quasi-stiffness of the human knee in the stance phase of walking by Shamaei, Kamran, Sawicki, Gregory S, Dollar, Aaron M

“…Biomechanical data characterizing the quasi-stiffness of lower-limb joints during human locomotion is limited. Understanding joint stiffness is critical for…”
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Simulations suggest walking with reduced propulsive force would not mitigate the energetic consequences of lower tendon stiffness by Pimentel, Richard E, Sawicki, Gregory S, Franz, Jason R

“…Aging elicits numerous effects that impact both musculoskeletal structure and walking function. Tendon stiffness (kT) and push-off propulsive force (FP) both…”
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The effects of plantarflexor weakness and reduced tendon stiffness with aging on gait stability by Smith, Ross E, Shelton, Andrew D, Sawicki, Gregory S, Franz, Jason R

“…Falls among older adults are a costly public health concern. Such falls can be precipitated by balance disturbances, after which a recovery strategy requiring…”
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Estimation of quasi-stiffness of the human hip in the stance phase of walking by Shamaei, Kamran, Sawicki, Gregory S, Dollar, Aaron M

“…This work presents a framework for selection of subject-specific quasi-stiffness of hip orthoses and exoskeletons, and other devices that are intended to…”
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A neuromechanics-based powered ankle exoskeleton to assist walking post-stroke: a feasibility study by Takahashi, Kota Z, Lewek, Michael D, Sawicki, Gregory S

“…In persons post-stroke, diminished ankle joint function can contribute to inadequate gait propulsion. To target paretic ankle impairments, we developed a…”
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Parametric equations to study and predict lower-limb joint kinematics and kinetics during human walking and slow running on slopes by Shkedy Rabani, Anat, Mizrachi, Sarai, Sawicki, Gregory S, Riemer, Raziel

“…Comprehensive data sets for lower-limb kinematics and kinetics during slope walking and running are important for understanding human locomotion neuromechanics…”
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Machine learning to extract muscle fascicle length changes from dynamic ultrasound images in real-time by Rosa, Luis G, Zia, Jonathan S, Inan, Omer T, Sawicki, Gregory S

“…Dynamic muscle fascicle length measurements through B-mode ultrasound have become popular for the non-invasive physiological insights they provide regarding…”
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Unconstrained muscle-tendon workloops indicate resonance tuning as a mechanism for elastic limb behavior during terrestrial locomotion by Robertson, Benjamin D., Sawicki, Gregory S.

“…In terrestrial locomotion, there is a missing link between observed spring-like limb mechanics and the physiological systems driving their emergence. Previous…”
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Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2–5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study by Davies, Jane C, Prof, Cunningham, Steve, MBChB, Harris, William T, MD, Lapey, Allen, MD, Regelmann, Warren E, MD, Sawicki, Gregory S, MD, Southern, Kevin W, MBChB, Robertson, Sarah, PharmD, Green, Yulia, MBChB, Cooke, Jon, MSc, Rosenfeld, Margaret, Prof

“…Summary Background Ivacaftor has been shown to be a safe, effective treatment for cystic fibrosis in patients aged 6 years or older with a CFTR gating…”
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Mechanics and energetics of post-stroke walking aided by a powered ankle exoskeleton with speed-adaptive myoelectric control by McCain, Emily M, Dick, Taylor J M, Giest, Tracy N, Nuckols, Richard W, Lewek, Michael D, Saul, Katherine R, Sawicki, Gregory S

“…Ankle exoskeletons offer a promising opportunity to offset mechanical deficits after stroke by applying the needed torque at the paretic ankle. Because joint…”
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Patient and family perceptions of telehealth as part of the cystic fibrosis care model during COVID-19 by Jaclyn, Davis, Andrew, NeSmith, Ryan, Perkins, Julianna, Bailey, Christopher, Siracusa, Nauman, Chaudary, Powers, M., Gregory S, Sawicki, George M, Solomon

“…•This survey-based study assessed patient and family experience of telehealth care during the COVID-19 pandemic.•Telehealth Care was viewed as feasible,…”
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Assessment of safety and efficacy of long-term treatment with combination lumacaftor and ivacaftor therapy in patients with cystic fibrosis homozygous for the F508del-CFTR mutation (PROGRESS): a phase 3, extension study by Konstan, Michael W, Dr Prof, McKone, Edward F, MD, Moss, Richard B, Prof, Marigowda, Gautham, MD, Tian, Simon, MD, Waltz, David, MD, Huang, Xiaohong, PhD, Lubarsky, Barry, PhD, Rubin, Jaime, MPH, Millar, Stefanie J, MS, Pasta, David J, MS, Mayer-Hamblett, Nicole, PhD, Goss, Christopher H, Prof, Morgan, Wayne, Prof, Sawicki, Gregory S, MD

“…Summary Background The 24-week safety and efficacy of lumacaftor/ivacaftor combination therapy was shown in two randomised controlled trials (RCTs)—TRAFFIC and…”
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