Search Results - "S. NANDA, JAGPREET"

Coordinated Movements of Eukaryotic Translation Initiation Factors eIF1, eIF1A, and eIF5 Trigger Phosphate Release from eIF2 in Response to Start Codon Recognition by the Ribosomal Preinitiation Complex by Nanda, Jagpreet S., Saini, Adesh K., Muñoz, Antonio M., Hinnebusch, Alan G., Lorsch, Jon R.

“…Accurate recognition of the start codon in an mRNA by the eukaryotic translation preinitiation complex (PIC) is essential for proper gene expression. The…”
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miR-153 as biomarker for cancer—functional role as tumor suppressor by THAKUR, SALONI, K. SAINI, ADESH, DAS, JOYDEEP, SAINI, VIPIN, BALHARA, PARIN, S. NANDA, JAGPREET, V. SAINI, REENA

“…MicroRNA-153 (miR-153), belongs to a class of small non-coding RNA. It is a critical regulator of gene expression at the post-transcriptional level which…”
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eIF1 Controls Multiple Steps in Start Codon Recognition during Eukaryotic Translation Initiation by Nanda, Jagpreet S., Cheung, Yuen-Nei, Takacs, Julie E., Martin-Marcos, Pilar, Saini, Adesh K., Hinnebusch, Alan G., Lorsch, Jon R.

“…Eukaryotic translation initiation factor (eIF) 1 is a central mediator of start codon recognition. Dissociation of eIF1 from the preinitiation complex (PIC)…”
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Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy by Martin-Marcos, Pilar, Nanda, Jagpreet S, Luna, Rafael E, Zhang, Fan, Saini, Adesh K, Cherkasova, Vera A, Wagner, Gerhard, Lorsch, Jon R, Hinnebusch, Alan G

“…In the current model of translation initiation by the scanning mechanism, eIF1 promotes an open conformation of the 40S subunit competent for rapidly loading…”
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Active yeast ribosome preparation using monolithic anion exchange chromatography by Munoz, Antonio M, Yourik, Paul, Rajagopal, Vaishnavi, Nanda, Jagpreet S, Lorsch, Jon R, Walker, Sarah E

“…In vitro studies of translation provide critical mechanistic details, yet purification of large amounts of highly active eukaryotic ribosomes remains a…”
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Reconstitution of yeast translation initiation by Acker, Michael G, Kolitz, Sarah E, Mitchell, Sarah F, Nanda, Jagpreet S, Lorsch, Jon R

“…To facilitate the mechanistic dissection of eukaryotic translation initiation we have reconstituted the steps of this process using purified Saccharomyces…”
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Identification of Genes Required for Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells In Vitro by Kohrt, Sarah E, Awadallah, Wisam N, Phillips, 3rd, Robert A, Case, Thomas C, Jin, Renjie, Nanda, Jagpreet S, Yu, Xiuping, Clark, Peter E, Yi, Yajun, Matusik, Robert J, Anderson, Philip D, Grabowska, Magdalena M

“…Castration-resistant prostate cancer can be treated with the antiandrogen enzalutamide, but responses and duration of response are variable. To identify genes…”
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Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome by Saini, Adesh K, Nanda, Jagpreet S, Lorsch, Jon R, Hinnebusch, Alan G

“…eIF1A is the eukaryotic ortholog of bacterial translation initiation factor IF1, but contains a helical domain and long unstructured N-terminal tail (NTT) and…”
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Increased nuclear factor I/B expression in prostate cancer correlates with AR expression by Nanda, Jagpreet S., Awadallah, Wisam N., Kohrt, Sarah E., Popovics, Petra, Cates, Justin M. M., Mirosevich, Janni, Clark, Peter E., Giannico, Giovanna A., Grabowska, Magdalena M.

“…Background Most prostate cancers express androgen receptor (AR), and our previous studies have focused on identifying transcription factors that modify AR…”
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Vimentin Expressed on Mycobacterium tuberculosis-Infected Human Monocytes Is Involved in Binding to the NKp46 Receptor by Garg, Ankita, Barnes, Peter F, Porgador, Angel, Roy, Sugata, Wu, Shiping, Nanda, Jagpreet S, Griffith, David E, Girard, William M, Rawal, Nenoo, Shetty, Sreerama, Vankayalapati, Ramakrishna

“…We previously showed that human NK cells used the NKp46 receptor to lyse Mycobacterium tuberculosis H37Ra-infected monocytes. To identify ligands on…”
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Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex by Saini, Adesh K, Nanda, Jagpreet S, Martin-Marcos, Pilar, Dong, Jinsheng, Zhang, Fan, Bhardwaj, Monika, Lorsch, Jon R, Hinnebusch, Alan G

“…eIF5 is the GTPase activating protein (GAP) for the eIF2 · GTP · Met-tRNAi (Met) ternary complex with a critical role in initiation codon selection. Previous…”
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Domain Truncation Studies Reveal That the Streptokinase-Plasmin Activator Complex Utilizes Long Range Protein-Protein Interactions with Macromolecular Substrate to Maximize Catalytic Turnover by Sundram, Vasudha, Nanda, Jagpreet S., Rajagopal, Kammara, Dhar, Jayeeta, Chaudhary, Anita, Sahni, Girish

“…To explore the interdomain co-operativity during human plasminogen (HPG) activation by streptokinase (SK), we expressed the cDNAs corresponding to each SK…”
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MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer by German, Beatriz, Alaiwi, Sarah A, Ho, Kun-Lin, Nanda, Jagpreet S, Fonseca, Marcos A, Burkhart, Deborah L, Sheahan, Anjali V, Bergom, Hannah E, Morel, Katherine L, Beltran, Himisha, Hwang, Justin H, Freedman, Matthew L, Lawrenson, Kate, Ellis, Leigh

“…Phenotypic plasticity is a recognized mechanism driving therapeutic resistance in patients with prostate cancer. Although underlying molecular causations…”
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Kinetic Analysis of Late Steps of Eukaryotic Translation Initiation by Acker, Michael G., Shin, Byung-Sik, Nanda, Jagpreet S., Saini, Adesh K., Dever, Thomas E., Lorsch, Jon R.

“…Little is known about the molecular mechanics of the late events of translation initiation in eukaryotes. We present a kinetic dissection of the transition…”
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Low tristetraprolin expression activates phenotypic plasticity and primes transition to lethal prostate cancer in mice by Morel, Katherine L., Germán, Beatriz, Hamid, Anis A., Nanda, Jagpreet S., Linder, Simon, Bergman, Andries M., van der Poel, Henk, Hofland, Ingrid, Bekers, Elise M., Trostel, Shana Y., Burkhart, Deborah L., Wilkinson, Scott, Ku, Anson T., Kim, Minhyung, Kim, Jina, Ma, Duanduan, Plummer, Jasmine T., You, Sungyong, Su, Xiaofeng A., Zwart, Wilbert, Sowalsky, Adam G., Sweeney, Christopher J., Ellis, Leigh

“…Phenotypic plasticity is a hallmark of cancer and increasingly realized as a mechanism of resistance to androgen receptor (AR)-targeted therapy. Now that many…”
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Involvement of a Nine-residue Loop of Streptokinase in the Generation of Macromolecular Substrate Specificity by the Activator Complex through Interaction with Substrate Kringle Domains by Dhar, Jayeeta, Pande, Abhay H., Sundram, Vasudha, Nanda, Jagpreet S., Mande, Shekhar C., Sahni, Girish

“…The selective deletion of a discrete surface-exposed epitope (residues 254–262; 250-loop) in the β domain of streptokinase (SK) significantly decreased the…”
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Substrate kringle-mediated catalysis by the streptokinase-plasmin activator complex: Critical contribution of kringle-4 revealed by the mutagenesis approaches by Joshi, Kishore K., Nanda, Jagpreet S., Kumar, Prakash, Sahni, Girish

“…Streptokinase (SK) is a protein co-factor with a potent capability for human plasminogen (HPG) activation. Our previous studies [1] have indicated a major role…”
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Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex by Saini, Adesh K, Nanda, Jagpreet S, Martin-Marcos, Pilar, Dong, Jinsheng, Zhang, Fan, Bhardwaj, Monika, Lorsch, Jon R, Hinnebusch, Alan G

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Labeling a protein with fluorophores using NHS ester derivitization by Nanda, Jagpreet S, Lorsch, Jon R

“…N-hydroxysuccinimde (NHS) ester-mediated derivitization involves the reaction of this amine-reactive group with the primary amines of a protein or a…”
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Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection by Dong, Jinsheng, Nanda, Jagpreet S, Rahman, Hafsa, Pruitt, Margaret R, Shin, Byung-Sik, Wong, Chi-Ming, Lorsch, Jon R, Hinnebusch, Alan G

“…High-resolution structures of bacterial 70S ribosomes have provided atomic details about mRNA and tRNA binding to the decoding center during elongation, but…”
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