Search Results - "S. Kean, Leslie"

Innovations present in the primate interneuron repertoire by Krienen, Fenna M., Goldman, Melissa, Zhang, Qiangge, C. H. del Rosario, Ricardo, Florio, Marta, Machold, Robert, Saunders, Arpiar, Levandowski, Kirsten, Zaniewski, Heather, Schuman, Benjamin, Wu, Carolyn, Lutservitz, Alyssa, Mullally, Christopher D., Reed, Nora, Bien, Elizabeth, Bortolin, Laura, Fernandez-Otero, Marian, Lin, Jessica D., Wysoker, Alec, Nemesh, James, Kulp, David, Burns, Monika, Tkachev, Victor, Smith, Richard, Walsh, Christopher A., Dimidschstein, Jordane, Rudy, Bernardo, S. Kean, Leslie, Berretta, Sabina, Fishell, Gord, Feng, Guoping, McCarroll, Steven A.

“…Primates and rodents, which descended from a common ancestor around 90 million years ago 1 , exhibit profound differences in behaviour and cognitive capacity;…”
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Current Concepts and Advances in Graft-Versus-Host Disease Immunology by Hill, Geoffrey R, Betts, Brian C, Tkachev, Victor, Kean, Leslie S, Blazar, Bruce R

“…Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell transplantation with the intent to cure high-risk hematologic…”
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Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis by Bolaños-Meade, Javier, Hamadani, Mehdi, Wu, Juan, Al Malki, Monzr M., Martens, Michael J., Runaas, Lyndsey, Elmariah, Hany, Rezvani, Andrew R., Gooptu, Mahasweta, Larkin, Karilyn T., Shaffer, Brian C., El Jurdi, Najla, Loren, Alison W., Solh, Melhem, Hall, Aric C., Alousi, Amin M., Jamy, Omer H., Perales, Miguel-Angel, Yao, Janny M., Applegate, Kristy, Bhatt, Ami S., Kean, Leslie S., Efebera, Yvonne A., Reshef, Ran, Clark, William, DiFronzo, Nancy L., Leifer, Eric, Horowitz, Mary M., Jones, Richard J., Holtan, Shernan G.

“…In this trial, 1-year GVHD-free, relapse-free survival after stem-cell transplantation was 52.7% in the cyclophosphamide–tacrolimus–mycophenolate mofetil group…”
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Advances in targeting co‐inhibitory and co‐stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy by Kean, Leslie S., Turka, Laurence A., Blazar, Bruce R.

“…Summary In the past decade, the power of harnessing T‐cell co‐signaling pathways has become increasingly understood to have significant clinical importance. In…”
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Pluripotent stem cells: immune to the immune system? by Pearl, Jeremy I, Kean, Leslie S, Davis, Mark M, Wu, Joseph C

“…Human embryonic stem cells (hESCs), initially thought to be immune privileged cells, are now known to be susceptible to immune recognition. Human induced…”
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Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform by Gerdemann, Ulrike, Fleming, Ryan A, Kaminski, James, McGuckin, Connor, Rui, Xianliang, Lane, Jennifer F, Keskula, Paula, Cagnin, Lorenzo, Shalek, Alex K, Tkachev, Victor, Kean, Leslie S

“…T cell receptor (TCR) clonotype tracking is a powerful tool for interrogating T cell mediated immune processes. New methods to pair a single cell's…”
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Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation by Colonna, Lucrezia, Peterson, Christopher W., Schell, John B., Carlson, Judith M., Tkachev, Victor, Brown, Melanie, Yu, Alison, Reddy, Sowmya, Obenza, Willi M., Nelson, Veronica, Polacino, Patricia S., Mack, Heather, Hu, Shiu-Lok, Zeleski, Katie, Hoffman, Michelle, Olvera, Joe, Furlan, Scott N., Zheng, Hengqi, Taraseviciute, Agne, Hunt, Daniel J., Betz, Kayla, Lane, Jennifer F., Vogel, Keith, Hotchkiss, Charlotte E., Moats, Cassie, Baldessari, Audrey, Murnane, Robert D., English, Christopher, Astley, Cliff A., Wangari, Solomon, Agricola, Brian, Ahrens, Joel, Iwayama, Naoto, May, Andrew, Stensland, Laurence, Huang, Meei-Li W., Jerome, Keith R., Kiem, Hans-Peter, Kean, Leslie S.

“…Allogeneic transplantation (allo-HCT) has led to the cure of HIV in one individual, raising the question of whether transplantation can eradicate the HIV…”
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Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention by Furlan, Scott N, Watkins, Benjamin, Tkachev, Victor, Flynn, Ryan, Cooley, Sarah, Ramakrishnan, Swetha, Singh, Karnail, Giver, Cindy, Hamby, Kelly, Stempora, Linda, Garrett, Aneesah, Chen, Jingyang, Betz, Kayla M, Ziegler, Carly G K, Tharp, Gregory K, Bosinger, Steven E, Promislow, Daniel E L, Miller, Jeffrey S, Waller, Edmund K, Blazar, Bruce R, Kean, Leslie S

“…Graft-versus-host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular…”
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Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation by Essawi, Khaled, Hakami, Waleed, Naeem Khan, Muhammad Behroz, Martin, Reid, Zeng, Jing, Chu, Rebecca, Uchida, Naoya, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Donahue, Robert E., Blobel, Gerd A., Gerdemann, Ulrike, Kean, Leslie S., Maitland, Stacy A., Wolfe, Scot A., Metais, Jean-Yves, Gottschalk, Stephen, Bauer, Daniel E., Tisdale, John F., Demirci, Selami

“…CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for…”
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Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis by Kean, Leslie S.

“…Cellular therapies play a major and expanding role in the treatment of hematologic diseases. For each of these therapies, a narrow therapeutic window exists,…”
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Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation by Kean, Leslie S, Blazar, Bruce R

“…The Haitian proverb "Beyond mountains, there are mountains" has many meanings. One that resonates for hematopoietic stem cell transplantation (HCT) over the…”
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Isolation of a Highly Purified HSC-enriched CD34+CD90+CD45RA− Cell Subset for Allogeneic Transplantation in the Nonhuman Primate Large-animal Model by Radtke, Stefan, Colonna, Lucrezia, Perez, Anai M., Hoffman, Michelle, Kean, Leslie S., Kiem, Hans-Peter

“…Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a common treatment for patients suffering from different hematological disorders. Allo-HCT in…”
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Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease by Socié, Gérard, Kean, Leslie S, Zeiser, Robert, Blazar, Bruce R

“…As a result of impressive increases in our knowledge of rodent and human immunology, the understanding of the pathophysiologic mechanisms underlying…”
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Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection by Beus, Jonathan M, Hashmi, Salila S, Selvaraj, Saranya A, Duan, Danxia, Stempora, Linda L, Monday, Stephanie A, Cheeseman, Jennifer A, Hamby, Kelly M, Speck, Samuel H, Larsen, Christian P, Kirk, Allan D, Kean, Leslie S

“…The mechanisms underlying latent-virus-mediated heterologous immunity, and subsequent transplant rejection, especially in the setting of T cell costimulation…”
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Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD by Watkins, Benjamin, Qayed, Muna, McCracken, Courtney, Bratrude, Brandi, Betz, Kayla, Suessmuth, Yvonne, Yu, Alison, Sinclair, Shauna, Furlan, Scott, Bosinger, Steven, Tkachev, Victor, Rhodes, James, Tumlin, Audrey Grizzle, Narayan, Alexandria, Cribbin, Kayla, Gillespie, Scott, Gooley, Ted A, Pasquini, Marcelo C, Hebert, Kyle, Kapoor, Urvi, Rogatko, Andre, Tighiouart, Mourad, Kim, Sungjin, Bresee, Catherine, Choi, Sung W, Davis, Jeffrey, Duncan, Christine, Giller, Roger, Grimley, Michael, Harris, Andrew C, Jacobsohn, David, Lalefar, Nahal, Norkin, Maxim, Farhadfar, Nosha, Pulsipher, Michael A, Shenoy, Shalini, Petrovic, Aleksandra, Schultz, Kirk R, Yanik, Gregory A, Waller, Edmund K, Levine, John E, Ferrara, James L, Blazar, Bruce R, Langston, Amelia, Horan, John T, Kean, Leslie S

“…Severe (grade 3-4) acute graft-versus-host disease (AGVHD) is a major cause of death after unrelated-donor (URD) hematopoietic cell transplant (HCT), resulting…”
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Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates by Taraseviciute, Agne, Tkachev, Victor, Ponce, Rafael, Turtle, Cameron J, Snyder, Jessica M, Liggitt, H Denny, Myerson, David, Gonzalez-Cuyar, Luis, Baldessari, Audrey, English, Chris, Yu, Alison, Zheng, Hengqi, Furlan, Scott N, Hunt, Daniel J, Hoglund, Virginia, Finney, Olivia, Brakke, Hannah, Blazar, Bruce R, Berger, Carolina, Riddell, Stanley R, Gardner, Rebecca, Kean, Leslie S, Jensen, Michael C

“…Chimeric antigen receptor (CAR) T-cell immunotherapy has revolutionized the treatment of refractory leukemias and lymphomas, but is associated with significant…”
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Human OX40L-CAR-T regs target activated antigen-presenting cells and control T cell alloreactivity by Rui, Xianliang, Alvarez Calderon, Francesca, Wobma, Holly, Gerdemann, Ulrike, Albanese, Alexandre, Cagnin, Lorenzo, McGuckin, Connor, Michaelis, Katherine A, Naqvi, Kisa, Blazar, Bruce R, Tkachev, Victor, Kean, Leslie S

“…Regulatory T cells (T ) make major contributions to immune homeostasis. Because T dysfunction can lead to both allo- and autoimmunity, there is interest in…”
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Creating an international network for science and clinical progress: democratizing dissemination of advances in global hematology by Kean, Leslie S.

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CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire by Suessmuth, Yvonne, Mukherjee, Rithun, Watkins, Benjamin, Koura, Divya T., Finstermeier, Knut, Desmarais, Cindy, Stempora, Linda, Horan, John T., Langston, Amelia, Qayed, Muna, Khoury, Hanna J., Grizzle, Audrey, Cheeseman, Jennifer A., Conger, Jason A., Robertson, Jennifer, Garrett, Aneesah, Kirk, Allan D., Waller, Edmund K., Blazar, Bruce R., Mehta, Aneesh K., Robins, Harlan S., Kean, Leslie S.

“…Although cytomegalovirus (CMV) reactivation has long been implicated in posttransplant immune dysfunction, the molecular mechanisms that drive this phenomenon…”
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Abatacept for acute graft-versus-host disease prophylaxis after unrelated donor hematopoietic cell transplantation by Kean, Leslie S., Burns, Linda J., Kou, Tzuyung D., Kapikian, Roxanne, Lozenski, Karissa, Langston, Amelia, Horan, John T., Watkins, Benjamin, Qayed, Muna, Bratrude, Brandi, Betz, Kayla, Tang, Xiao-Ying, Zhang, Mei-Jie, Connolly, Sean E., Polinsky, Martin, Gavin, Brian, Gomez-Caminero, Andres, Pasquini, Marcelo C.

“…•This study illustrates the survival benefits of abatacept combined with CNI/MTX in patients with hematologic malignancies undergoing HCT.•The addition of…”
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