Search Results - "S. Gokhan"

Foundations of Immunometabolism and Implications for Metabolic Health and Disease by Hotamisligil, Gökhan S.

“…Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of…”
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Inflammation, metaflammation and immunometabolic disorders by Hotamisligil, Gökhan S.

“…Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to…”
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Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment by Ertunc, Meric Erikci, Hotamisligil, Gökhan S.

“…Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids, and triglycerides. These molecules represent a highly efficient…”
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Cell Signaling and Stress Responses by Hotamisligil, Gökhan S, Davis, Roger J

“…Stress-signaling pathways are evolutionarily conserved and play an important role in the maintenance of homeostasis. These pathways are also critical for…”
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Metabolic Messengers: tumour necrosis factor by Sethi, Jaswinder K., Hotamisligil, Gökhan S.

“…Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also the first ‘adipokine’ described to be produced from adipose…”
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The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue by Lynes, Matthew D, Leiria, Luiz O, Lundh, Morten, Bartelt, Alexander, Shamsi, Farnaz, Huang, Tian Lian, Takahashi, Hirokazu, Hirshman, Michael F, Schlein, Christian, Lee, Alexandra, Baer, Lisa A, May, Francis J, Gao, Fei, Narain, Niven R, Chen, Emily Y, Kiebish, Michael A, Cypess, Aaron M, Blüher, Matthias, Goodyear, Laurie J, Hotamisligil, Gökhan S, Stanford, Kristin I, Tseng, Yu-Hua

“…Cold stimulation induces the synthesis and release of the lipid species 12,13-diHOME from brown adipose tissue. This ‘lipokine’ then acts on brown adipocytes…”
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Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance by Tilg, Herbert, Hotamisligil, Gökhan S.

“…Nonalcoholic fatty liver disease (NAFLD), the major reason for abnormal liver function in the Western world, is associated with obesity and diabetes and is…”
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A hormone complex of FABP4 and nucleoside kinases regulates islet function by Prentice, Kacey J., Saksi, Jani, Robertson, Lauren T., Lee, Grace Y., Inouye, Karen E., Eguchi, Kosei, Lee, Alexandra, Cakici, Ozgur, Otterbeck, Emily, Cedillo, Paulina, Achenbach, Peter, Ziegler, Anette-Gabriele, Calay, Ediz S., Engin, Feyza, Hotamisligil, Gökhan S.

“…The liberation of energy stores from adipocytes is critical to support survival in times of energy deficit; however, uncontrolled or chronic lipolysis…”
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The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans by Tirosh, Amir, Calay, Ediz S, Tuncman, Gurol, Claiborn, Kathryn C, Inouye, Karen E, Eguchi, Kosei, Alcala, Michael, Rathaus, Moran, Hollander, Kenneth S, Ron, Idit, Livne, Rinat, Heianza, Yoriko, Qi, Lu, Shai, Iris, Garg, Rajesh, Hotamisligil, Gökhan S

“…The short-chain fatty acid propionate is a potent inhibitor of molds that is widely used as a food preservative and endogenously produced by gut microbiota…”
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Regulation of liver subcellular architecture controls metabolic homeostasis by Parlakgül, Güneş, Arruda, Ana Paula, Pang, Song, Cagampan, Erika, Min, Nina, Güney, Ekin, Lee, Grace Yankun, Inouye, Karen, Hess, Harald F., Xu, C. Shan, Hotamışlıgil, Gökhan S.

“…Cells display complex intracellular organization by compartmentalization of metabolic processes into organelles, yet the resolution of these structures in the…”
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Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms by Brozzi, Flora, Nardelli, Tarlliza R., Lopes, Miguel, Millard, Isabelle, Barthson, Jenny, Igoillo-Esteve, Mariana, Grieco, Fabio A., Villate, Olatz, Oliveira, Joana M., Casimir, Marina, Bugliani, Marco, Engin, Feyza, Hotamisligil, Gökhan S., Marchetti, Piero, Eizirik, Decio L.

“…Aims/hypothesis Proinflammatory cytokines contribute to beta cell damage in type 1 diabetes in part through activation of endoplasmic reticulum (ER) stress. In…”
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Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes by MOZAFFARIAN, Dariush, HAIMING CAO, KING, Irena B, LEMAITRE, Rozenn N, XIAOLING SONG, SISCOVICK, David S, HOTAMISLIGIL, Gökhan S

“…Animal experiments suggest that circulating palmitoleic acid (cis-16:1n-7) from adipocyte de novo fatty acid synthesis may directly regulate insulin resistance…”
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Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity by Bartelt, Alexander, Widenmaier, Scott B, Schlein, Christian, Johann, Kornelia, Goncalves, Renata L S, Eguchi, Kosei, Fischer, Alexander W, Parlakgül, Günes, Snyder, Nicole A, Nguyen, Truc B, Bruns, Oliver T, Franke, Daniel, Bawendi, Moungi G, Lynes, Matthew D, Leiria, Luiz O, Tseng, Yu-Hua, Inouye, Karen E, Arruda, Ana Paula, Hotamisligil, Gökhan S

“…Nrf1-mediated proteosome activity in brown fat is required for the normal thermogenic behavior of this tissue in mice. Adipocytes possess remarkable adaptive…”
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NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis by Widenmaier, Scott B., Snyder, Nicole A., Nguyen, Truc B., Arduini, Alessandro, Lee, Grace Y., Arruda, Ana Paula, Saksi, Jani, Bartelt, Alexander, Hotamisligil, Gökhan S.

“…Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its uniquely challenging biophysical properties. While…”
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Novel role of PKR in inflammasome activation and HMGB1 release by Lu, Ben, Nakamura, Takahisa, Inouye, Karen, Li, Jianhua, Tang, Yiting, Lundbäck, Peter, Valdes-Ferrer, Sergio I., Olofsson, Peder S., Kalb, Thomas, Roth, Jesse, Zou, Yongrui, Erlandsson-Harris, Helena, Yang, Huan, Ting, Jenny P.-Y., Wang, Haichao, Andersson, Ulf, Antoine, Daniel J., Chavan, Sangeeta S., Hotamisligil, Gökhan S., Tracey, Kevin J.

“…Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release…”
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De Novo Lipogenesis Products and Endogenous Lipokines by Yilmaz, Mustafa, Claiborn, Kathryn C, Hotamisligil, Gökhan S

“…Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates, lipids…”
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Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice by Liu, Cong-Lin, Ren, Jingyuan, Wang, Yunzhe, Zhang, Xian, Sukhova, Galina K, Liao, Mengyang, Santos, Marcela, Luo, Songyuan, Yang, Dafeng, Xia, Mingcan, Inouye, Karen, Hotamisligil, Gökhan S, Lu, Guanyi, Upchurch, Gilbert R, Libby, Peter, Guo, Junli, Zhang, Jinying, Shi, Guo-Ping

“…Abstract Aims Obesity is a risk factor of abdominal aortic aneurysm (AAA). Inflammatory cytokine interleukin-18 (IL18) has two receptors: IL18 receptor (IL18r)…”
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The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB by Zhang, Zeyuan, Qian, Qingwen, Li, Mark, Shao, Fan, Ding, Wen-Xing, Lira, Vitor A., Chen, Sophia X., Sebag, Sara C., Hotamisligil, Gökhan S., Cao, Huojun, Yang, Ling

“…Defective macroautophagy/autophagy and a failure to initiate the adaptive unfolded protein response (UPR) in response to the endoplasmic reticulum (ER) stress…”
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Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism by Tirosh, Amir, Tuncman, Gurol, Calay, Ediz S., Rathaus, Moran, Ron, Idit, Tirosh, Amit, Yalcin, Abdullah, Lee, Yankun G., Livne, Rinat, Ron, Sophie, Minsky, Neri, Arruda, Ana Paula, Hotamisligil, Gökhan S.

“…Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains…”
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Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages by Zhou, Yi, Yu, Xueqing, Chen, Huimei, Sjöberg, Sara, Roux, Joséphine, Zhang, Lijun, Ivoulsou, Al-Habib, Bensaid, Farid, Liu, Cong-Lin, Liu, Jian, Tordjman, Joan, Clement, Karine, Lee, Chih-Hao, Hotamisligil, Gokhan S., Libby, Peter, Shi, Guo-Ping

“…Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-inflammatory…”
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