Search Results - "S. Carter, Bob"
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Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles
Published in Nature communications (12-01-2018)“…Extracellular vesicles (EVs) carry RNA, DNA, proteins, and lipids. Specifically, tumor-derived EVs have the potential to be utilized as disease-specific…”
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Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
Published in Nature communications (11-05-2015)“…Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a…”
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Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
Published in Nature medicine (01-12-2012)“…Cancer cells shed large numbers of small, membrane-bound microvesicles (MVs) into the circulation, which have diagnostic potential but have proved difficult to…”
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Extracellular Vesicles in Glioblastoma Tumor Microenvironment
Published in Frontiers in immunology (21-01-2020)“…Glioblastomas (GBM) are highly aggressive primary brain tumors. Complex and dynamic tumor microenvironment (TME) plays a crucial role in the sustained growth,…”
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Rapid Isolation and Detection of Exosomes and Associated Biomarkers from Plasma
Published in ACS nano (25-07-2017)“…Exosomes found in the circulation are a primary source of important cancer-related RNA and protein biomarkers that are expected to lead to early detection,…”
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Endonasal instrumentation and aerosolization risk in the era of COVID‐19: simulation, literature review, and proposed mitigation strategies
Published in International forum of allergy & rhinology (01-07-2020)“…Background International experience with coronavirus 2019 (COVID‐19) suggests it poses a significant risk of infectious transmission to skull base surgeons,…”
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MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development
Published in PloS one (21-10-2013)“…Glioblastoma cells secrete extra-cellular vesicles (EVs) containing microRNAs (miRNAs). Analysis of these EV miRNAs in the bio-fluids of afflicted patients…”
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Airborne Aerosol Generation During Endonasal Procedures in the Era of COVID-19: Risks and Recommendations
Published in Otolaryngology-head and neck surgery (01-09-2020)“…Objective In the era of SARS-CoV-2, the risk of infectious airborne aerosol generation during otolaryngologic procedures has been an area of increasing…”
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Characterization and Correction of Geometric Distortions in 814 Diffusion Weighted Images
Published in PloS one (30-03-2016)“…Diffusion Weighted Imaging (DWI), which is based on Echo Planar Imaging (EPI) protocols, is becoming increasingly important for neurosurgical applications…”
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Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects
Published in Progress in neurobiology (01-09-2018)“…Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which affects about 0.3% of the general population. As the population in the…”
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Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients
Published in Neuro-oncology (Charlottesville, Va.) (19-10-2017)“…RNAs within extracellular vesicles (EVs) have potential as diagnostic biomarkers for patients with cancer and are identified in a variety of biofluids…”
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Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile
Published in Alzheimer's & dementia : diagnosis, assessment & disease monitoring (2016)“…Abstract Introduction Levels of Alzheimer's disease (AD)-related proteins in plasma neuronal derived exosomes (NDEs) were quantified to identify biomarkers for…”
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TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Published in Clinical cancer research (01-01-2021)“…Liquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time and therapy. Detection of…”
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CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma
Published in Journal for immunotherapy of cancer (14-11-2019)“…Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local…”
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Blood-based biomarkers for the diagnosis and monitoring of gliomas
Published in Neuro-oncology (Charlottesville, Va.) (02-08-2018)“…Monitoring patient response to treatment is challenging for most cancers, but it is particularly difficult in glioblastoma multiform, the most common and…”
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Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF)
Published in PloS one (22-02-2016)“…Extracellular vesicles (EVs) have emerged as a promising biomarker platform for glioblastoma patients. However, the optimal method for quantitative assessment…”
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Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma
Published in PloS one (05-07-2018)“…Glioblastoma multiforme (GBM) is the most aggressive and deadly form of adult brain cancer. Despite of many attempts to identify potential therapies for this…”
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Oligodendroglioma resection: a Surveillance, Epidemiology, and End Results (SEER) analysis
Published in Journal of neurosurgery (01-04-2018)“…OBJECTIVE The available evidence suggests that the clinical benefits of extended resection are limited for chemosensitive tumors, such as primary CNS lymphoma…”
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miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients
Published in Journal of neuro-oncology (01-06-2015)“…Analysis of extracellular vesicles (EVs) derived from plasma or cerebrospinal fluid (CSF) has emerged as a promising biomarker platform for therapeutic…”
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Microfluidic isolation and transcriptome analysis of serum microvesicles
Published in Lab on a chip (01-01-2010)“…Microvesicles (exosomes) shed from both normal and cancerous cells may serve as means of intercellular communication. These microvesicles carry proteins,…”
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