Search Results - "S. Boukouvala"

A Homogenizing Process of Selection Has Maintained an “Ultra-Slow” Acetylation NAT2 Variant in Humans by Patillon, B., Luisi, P., Poloni, E. S., Boukouvala, S., Darlu, P., Genin, E., Sabbagh, A.

“…N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic…”
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Pharmacogenetics of the arylamine N-acetyltransferases by BUTCHER, N. J, BOUKOUVALA, S, SIM, E, MINCHIN, R. F

“…The arylamine N-acetyltransferases (NATs) are involved in the metabolism of a variety of different compounds that we are exposed to on a daily basis. Many…”
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Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos by Smelt, V A, Upton, A, Adjaye, J, Payton, M A, Boukouvala, S, Johnson, N, Mardon, H J, Sim, E

“…Arylamine N -acetyltransferases (NATs) catalyse the acetylation from acetyl-CoA of arylamines and hydrazines. There are two human isoenzymes which show…”
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Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene by Cornish, V A, Pinter, K, Boukouvala, S, Johnson, N, Labrousse, C, Payton, M, Priddle, H, Smith, A J H, Sim, E

“…Arylamine N-acetyltransferases (NATs) are polymorphic xenobiotic metabolising enzymes, linked to cancer susceptibility in a variety of tissues. In humans and…”
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Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2 by Fakis, G, Boukouvala, S, Buckle, V, Payton, M, Denning, C, Sim, E

“…Arylamine N-acetyltransferases (NATs) catalyse acetylation reactions which can result in either detoxification or activation of arylamine carcinogens. The…”
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PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2 by McDonagh, Ellen M, Boukouvala, Sotiria, Aklillu, Eleni, Hein, David W, Altman, Russ B, Klein, Teri E

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Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting by Kalman, LV, Agúndez, JAG, Appell, M Lindqvist, Black, JL, Bell, GC, Boukouvala, S, Bruckner, C, Bruford, E, Caudle, K, Coulthard, SA, Daly, AK, Tredici, AL Del, den Dunnen, JT, Drozda, K, Everts, RE, Flockhart, D, Freimuth, RR, Gaedigk, A, Hachad, H, Hartshorne, T, Ingelman-Sundberg, M, Klein, TE, Lauschke, VM, Maglott, DR, McLeod, HL, McMillin, GA, Meyer, UA, Müller, DJ, Nickerson, DA, Oetting, WS, Pacanowski, M, Pratt, VM, Relling, MV, Roberts, A, Rubinstein, WS, Sangkuhl, K, Schwab, M, Scott, SA, Sim, SC, Thirumaran, RK, Toji, LH, Tyndale, RF, van Schaik, RHN, Whirl-Carrillo, M, Yeo, KTJ, Zanger, UM

“…This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic…”
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Arylamine N-Acetyltransferases: What We Learn from Genes and Genomes by Boukouvala, Sotiria, Fakis, Giannoulis

“…Arylamine N-acetyltransferases (NATs) are phase II xenobiotic metabolizing enzymes, catalyzing acetyl-CoA-dependent N- and O-acetylation reactions. All NATs…”
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Structural Analysis of the Genes for Human Arylamine N‐Acetyltransferases and Characterisation of Alternative Transcripts by Boukouvala, Sotiria, Sim, Edith

“…: Arylamine N‐acetyltransferases are polymorphic drug‐metabolising enzymes. The human isoforms, NAT1 and NAT2, are encoded by two genes with intronless coding…”
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A Homogenizing Process of Selection Has Maintained an “Ultra-Slow” AcetylationNAT2Variant in Humans by B. Patillon, P. Luisi, E. S. Poloni, S. Boukouvala, P. Darlu, E. Genin, A. Sabbagh

“…N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic…”
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Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis by Fakis, Giannoulis, Boukouvala, Sotiria, Kawamura, Akane, Kennedy, Stephen

“…OBJECTIVESCase–control studies have previously associated polymorphisms in the gene encoding the xenobiotic metabolizing enzyme arylamine N-acetyltransferase 2…”
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Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice by Boukouvala, Sotiria, Price, Naomi, Plant, Kathryn E, Sim, Edith

“…Arylamine N-acetyltransferases (NATs) are polymorphic enzymes, well-known for their role in the metabolism of drugs and carcinogens. Mice have three NAT…”
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Expression of arylamine N-acetyltransferases in preterm placentas and in human pre-implantation embryos by SMELT, V. A, UPTON, A, ADJAYE, J, PAYTON, M. A, BOUKOUVALA, S, JOHNSON, N, MARDON, H. J, SIM, E

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Identification and functional characterization of novel polymorphisms associated with the genes for arylamine n-acetyltransferases in mice by BOUKOUVALA, Sotiria, PRICE, Naomi, SIM, Edith

“…Arylamine N-acetyltransferase (NAT) polymorphism in humans has been associated with variation in susceptibility to drug toxicity and cancer. In mice, three NAT…”
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