A nonadherent chitosan-polyvinyl alcohol absorbent wound dressing prepared via controlled freeze-dry technology

In modern-day 21st century, the demand has increased for absorbent dressings that are nonadherent and maintain structural integrity without shedding lint in the wound site. This study looks at the development of a blend of polysaccharide chitosan and polyvinyl alcohol (PVA) and its fabrication using...

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Bibliographic Details
Published in:	International journal of biological macromolecules Vol. 150; pp. 129 - 140
Main Authors:	S., Shyna, A., Shanti Krishna, Nair, Prabha D., Thomas, Lynda V.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-05-2020
Subjects:	Absorbent wound dressing Animals Bandages Biocompatible Materials - chemistry Chitosan Chitosan - chemistry Freeze drying Freeze Drying - methods Hemolysis Humans Hydrogen-Ion Concentration Mechanical Phenomena Molecular Structure Non-adherent dressing Poly (vinyl alcohol) Polyvinyl Alcohol - chemistry Spectrum Analysis Wound Healing Freeze drying Chitosan Absorbent wound dressing Poly (vinyl alcohol) Non-adherent dressing
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Summary:	In modern-day 21st century, the demand has increased for absorbent dressings that are nonadherent and maintain structural integrity without shedding lint in the wound site. This study looks at the development of a blend of polysaccharide chitosan and polyvinyl alcohol (PVA) and its fabrication using a novel controlled freeze-drying process, thus giving it channeled pores. The dressing was assessed for in vitro physical properties such as fluid handling, mechanical integrity, bioadhesion, and blood clotting. Additionally, cytocompatibility and hemocompatibility tests were conducted. An in vitro wound-healing assay was performed to determine the healing response. Furthermore, toxicological safety evaluation tests such as acute systemic toxicity, skin irritation, and sensitization were conducted. The results revealed that the developed dressing was biocompatible with a good absorbency rate of 0.63 ± 0.13 g/cm2, enhanced mechanical integrity, and low bioadhesive strength with good healing characteristics and nontoxic nature, which indicated that it was an ideal nonadherent absorbent wound dressing. •Crosslinked Chitosan-PVA wound dressing was developed via controlled freeze drying.•Porous dressing exhibits excellent fluid handling properties and moisture retention.•Soft and pliable dressing has low bioadhesive force with good mechanical strength.•The dressing is biocompatible and qualifies the toxicological safety studies.
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2020.01.292