Search Results - "S M Scesney"

Complement activation as a cause for primary graft failure in an isogeneic rat model of hypothermic lung preservation and transplantation by NAKA, Y, MARSH, H. C, SCESNEY, S. M, OZ, M. C, PINSKY, D. J

“…Although agents that inhibit complement activation may be beneficial in discordant xenotransplantation, it is not known whether local complement activation…”
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Cell surface expression of the C3b/C4b receptor (CR1) protects Chinese hamster ovary cells from lysis by human complement by S C Makrides, S M Scesney, P J Ford, K S Evans, G R Carson, H C Marsh, Jr

“…The C3b/C4b receptor, also known as complement receptor type 1 (CR1, CD35), is a single chain glycoprotein consisting of 30 repeating homologous protein…”
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Effect of repetitive high-dose treatment with soluble complement receptor type 1 and cobra venom factor on discordant xenograft survival by CANDINAS, D, LESNIKOSKI, B.-A, ROBSON, S. C, MIYATAKE, T, SCESNEY, S. M, MARSH, H. C, RYAN, U. S, DALMASSO, A. P, HANCOCK, W. W, BACH, F. H

“…Hyperacute xenograft rejection may be modified by the activation and depletion of complement (C) using cobra venom factor (CVF). This method of prolonging…”
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Recombinant soluble human complement receptor type 1 inhibits inflammation in the reversed passive arthus reaction in rats by Yeh, CG, Marsh, HC, Jr, Carson, GR, Berman, L, Concino, MF, Scesney, SM, Kuestner, RE, Skibbens, R, Donahue, KA, Ip, SH

“…The human CR1 was genetically engineered by site directed mutagenesis into a truncated form which was secreted from transfected Chinese hamster ovary cells…”
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Design, Synthesis, and Evaluation of A-, C-, and D-Ring Analogs of the Fungal Metabolite K-76 as Potential Complement Inhibitors by Kaufman, Teodoro S, Srivastava, Ranjan P, Sindelar, Robert D, Scesney, Susanne M, Marsh, Henry C

“…The terpenoid 6,7-diformyl-3',4',4a',5',6',7',8',8a'-octahydro-4,6',7'-trihydrox y-2',5',5', 8a'-tetramethylspiro[1'(2'H)-naphthalene-2(3H)-benzofuran] (1a;…”
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Interleukin-2-Induced Lung Injury: The Role of Complement by Rabinovici, R, Sofronski, M D, Borboroglu, P, Spirig, A M, Hillegas, L M, Levine, J, Vernick, J, Scesney, S M, Feuerstein, N, Feuerstein, G

“…Pulmonary edema and sepsislike syndrome are grave complications of interleukin-2 (IL-2) therapy. Recent animal studies have suggested IL-2-induced…”
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Soluble complement receptor type 1 and cobra venom factor in discordant xenotransplantation by Candinas, D, Lesnikoski, B A, Robson, S C, Scesney, S M, Otsu, I, Myiatake, T, Marsh, Jr, H C, Ryan, U S, Hancock, W W, Bach, F H

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Recombinant Glycoproteins That Inhibit Complement Activation and Also Bind the Selectin Adhesion Molecules by Rittershaus, C W, Thomas, L J, Miller, D P, Picard, M D, Geoghegan-Barek, K M, Scesney, S M, Henry, L D, Sen, A C, Bertino, A M, Hannig, G, Adari, H, Mealey, R A, Gosselin, M L, Couto, M, Hayman, E G, Levin, J L, Reinhold, V N, Marsh, Jr, H C

“…Soluble human complement receptor type 1 (sCR1, TP10) has been expressed in Chinese hamster ovary (CHO) DUKX-B11 cells and shown to inhibit the classical and…”
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A soluble deletion mutant of the human complement receptor type 1, which lacks the C4b binding site, is a selective inhibitor of the alternative complement pathway by Scesney, S M, Makrides, S C, Gosselin, M L, Ford, P J, Andrews, B M, Hayman, E G, Marsh, Jr, H C

“…The human complement receptor type 1 (CR1, CD35), is a single-chain glycoprotein consisting of 30 repeating homologous protein domains known as short consensus…”
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Synthesis and Complement Inhibitory Activity of B/C/D-Ring Analogues of the Fungal Metabolite 6,7-Diformyl-3‘,4‘,4a‘,5‘,6‘,7‘,8‘,8a‘-octahydro-4,6‘,7‘-trihydroxy- 2‘,5‘,5‘,8a‘-tetramethylspiro[1‘(2‘H)-naphthalene-2(3H)-benzofuran] by Bradbury, Barton J, Bartyzel, Piotr, Kaufman, Teodoro S, Nieto, Marcelo J, Sindelar, Robert D, Scesney, Susanne M, Gaumond, Bruce R, Marsh, Henry C

“…This paper reports the synthesis and the bioassay of 4-methoxy- and 4-hydroxyspiro[benzofuran-2(3H)-cyclohexane] partial analogues (5) of the complement…”
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Interrleukin-2-induced lung injury : the role of complement by RABINOVICI, R, SOFRONSKI, M. D, BORBOROGLU, P, SPIRIG, A. M, HILLEGAS, L. M, LEVINE, J, VERNICK, J, SCESNEY, S. M, FEUERSTEIN, N, FEUERSTEIN, G

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The design, synthesis and evaluation of A,C,D-ring analogs of the fungal metabolite K-76 as complement inhibitors: a potential probe for the absolute stereochemistry at position 2 by Kaufman, Teodoro S., Srivastava, Ranjan P., Sindelar, Robert D., Scesney, Susanne M., Marsh, Henry C.

“…In an attempt to synthesize stereochemically pure new A, C, D-ring analogs of the natural product complement inhibitor K-76, compounds ( 20–24) were prepared…”
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