Search Results - "Špičáková, Alena"

In Vitro Interaction of Binuclear Copper Complexes with Liver Drug-Metabolizing Cytochromes P450 by Špičáková, Alena, Horáčková, Zuzana, Kopel, Pavel, Anzenbacher, Pavel

“…Two copper(II) mixed ligand complexes with dicarboxylate bridges were prepared and studied, namely [Cu (μ-fu)(pmdien) (H O) ](ClO ) (complex No. 5) and [Cu…”
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Lipophosphonoxins—A Novel Group of Broad Spectrum Antibacterial Compounds by Šebek, Viktor, Anzenbacher, Pavel, Rejman, Dominik, Špičáková, Alena, Kolář, Milan

“…Lipophosphonoxins (LPPOs) represent a new group of membrane-targeting antibiotics. Three generations of LPPOs have been described: First-generation LPPOs,…”
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The inhibitory effects of β-caryophyllene, β-caryophyllene oxide and α-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro by Nguyen, Linh Thuy, Myslivečková, Zuzana, Szotáková, Barbora, Špičáková, Alena, Lněničková, Kateřina, Ambrož, Martin, Kubíček, Vladimír, Krasulová, Kristýna, Anzenbacher, Pavel, Skálová, Lenka

“…Sesquiterpenes, the main components of plant essential oils, are often taken in the form of folk medicines and dietary supplements. Several sesquiterpenes…”
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In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6 by Dvořák, Zdeněk, Vyhlídalová, Barbora, Pečinková, Petra, Li, Hao, Anzenbacher, Pavel, Špičáková, Alena, Anzenbacherová, Eva, Chow, Vimanda, Liu, Jiabao, Krause, Henry, Wilson, Derek, Berés, Tibor, Tarkowski, Petr, Chen, Dajun, Mani, Sridhar

“…[Display omitted] •FKK6 is a PXR-selective ligand and agonist.•FKK6 has high intestinal cell permeability, and rapid microsomal metabolism.•FKK6 metabolites…”
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Structure–Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists by Sedlák, David, Wilson, Tyler A, Tjarks, Werner, Radomska, Hanna S, Wang, Hongyan, Kolla, Jayaprakash Narayana, Leśnikowski, Zbigniew J, Špičáková, Alena, Ali, Tehane, Ishita, Keisuke, Rakotondraibe, Liva Harinantenaina, Vibhute, Sandip, Wang, Dasheng, Anzenbacher, Pavel, Bennett, Chad, Bartunek, Petr, Coss, Christopher C

“…Selective agonism of the estrogen receptor (ER) subtypes, ERα and ERβ, has historically been difficult to achieve due to the high degree of ligand-binding…”
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Acute drug intoxication in childhood: a 10-year retrospective observational single-centre study and case reports by Matalova, Petra, Buchta, Michal, Drietomska, Vendula, Spicakova, Alena, Wawruch, Martin, Ondra, Peter, Urbanek, Karel

“…Background. Medication poisoning in children is a severe condition that can endanger a child's life. Although drug intoxications are easily preventable,…”
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Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions by Špičáková, Alena, Szotáková, Barbora, Dimunová, Diana, Myslivečková, Zuzana, Kubíček, Vladimír, Ambrož, Martin, Lněničková, Kateřina, Krasulová, Kristýna, Anzenbacher, Pavel, Skálová, Lenka

“…Sesquiterpenes, 15-carbon compounds formed from three isoprenoid units, are the main components of plant essential oils. Sesquiterpenes occur in human food,…”
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In vitro and in silico studies of interaction of synthetic 2,6,9-trisubstituted purine kinase inhibitors BPA-302, BP-21 and BP-117 with liver drug-metabolizing cytochromes P450 by Špičáková, A, Kraus, P, Gucký, T, Kryštof, V, Strnad, M, Bazgier, V, Otyepka, M, Kubíčková, V, Poruba, M, Rácová, Z, Zapletalová, I, Anzenbacher, P

“…An evaluation of possible interactions with enzymes of drug metabolism (cytochromes P450, CYP) is an important part of studies on safety and, in general, on…”
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Interaction of rocuronium with human liver cytochromes P450 by Anzenbacherova, Eva, Spicakova, Alena, Jourova, Lenka, Ulrichova, Jitka, Adamus, Milan, Bachleda, Petr, Anzenbacher, Pavel

“…Rocuronium is a neuromuscular blocking agent acting as a competitive antagonist of acetylcholine. Results of an inhibition of eight individual liver microsomal…”
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Rosuvastatin suppresses the liver microsomal CYP2C11 and CYP2C6 expression in male Wistar rats by Zacha ová, Alice, Šiller, Michal, Špi áková, Alena, Anzenbacherová, Eva, Škottová, Nina, Anzenbacher, Pavel, Ve e a, Rostislav

“…The aim was to investigate whether rosuvastatin affect rat cytochrome P450 (CYP) 2C11 and CYP2C6. CYP2C11 and CYP2C6 are considered as counterparts of human…”
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Hepatocellular carcinoma: Gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450 by Nekvindova, Jana, Mrkvicova, Alena, Zubanova, Veronika, Hyrslova Vaculova, Alena, Anzenbacher, Pavel, Soucek, Pavel, Radova, Lenka, Slaby, Ondrej, Kiss, Igor, Vondracek, Jan, Spicakova, Alena, Bohovicova, Lucia, Fabian, Pavel, Kala, Zdenek, Palicka, Vladimir

“…[Display omitted] Hepatocellular carcinoma (HCC) remains a highly prevalent and deadly disease, being among the top causes of cancer-related deaths worldwide…”
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Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators by Spicakova, Alena, Anzenbacher, Pavel, Liskova, Barbora, Kuca, Kamil, Fusek, Josef, Anzenbacherova, Eva

“…Two non-symmetric bispyridine oxime – based reactivators of acetylcholinesterase enzyme (AChE), labeled as K027…”
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