Search Results - "Šolaja, Bogdan A."

4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania by Manzano, José Ignacio, Konstantinović, Jelena, Scaccabarozzi, Diletta, Perea, Ana, Pavić, Aleksandar, Cavicchini, Loredana, Basilico, Nicoletta, Gamarro, Francisco, Šolaja, Bogdan A.

“…Among neglected tropical diseases, leishmaniasis is one of the most relevant with an estimated 30,000 deaths annually. Existing therapies have serious…”
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Iron salt-promoted oxidation of steroidal phenols by m -chloroperbenzoic acid: a route to possible antitumor agents by Kop, Tatjana J., Terzić-Jovanović, Nataša, Žižak, Željko, Šolaja, Bogdan A., Milić, Dragana R.

“…A new oxidant, containing m -chloroperoxybenzoic acid (MCPBA) and an iron salt, was developed and used for oxidation of steroidal phenols to a…”
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New Chimeric Antimalarials with 4-Aminoquinoline Moiety Linked to a Tetraoxane Skeleton by Opsenica, Igor, Opsenica, Dejan, Lanteri, Charlotte Anne, Anova, Lalaine, Milhous, Wilbur K, Smith, Kirsten S, Šolaja, Bogdan A

“…The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8…”
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Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates by Ajdačić, Vladimir, Senerovic, Lidija, Vranić, Marija, Pekmezovic, Marina, Arsic-Arsnijevic, Valentina, Veselinovic, Aleksandar, Veselinovic, Jovana, Šolaja, Bogdan A., Nikodinovic-Runic, Jasmina, Opsenica, Igor M.

“…[Display omitted] A series of new thiophene-based guanylhydrazones (iminoguanidines) were synthesized in high yields using a straightforward two-step…”
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Reinvestigating Old Pharmacophores: Are 4‑Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials? by Terzić, Natasa, Konstantinović, Jelena, Tot, Mikloš, Burojević, Jovana, Djurković-Djaković, Olgica, Srbljanović, Jelena, Štajner, Tijana, Verbić, Tatjana, Zlatović, Mario, Machado, Marta, Albuquerque, Inês S, Prudêncio, Miguel, Sciotti, Richard J, Pecic, Stevan, D’Alessandro, Sarah, Taramelli, Donatella, Šolaja, Bogdan A

“…The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited…”
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New Steroidal 4‑Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model by Konstantinović, Jelena, Kiris, Erkan, Kota, Krishna P, Kugelman-Tonos, Johanny, Videnović, Milica, Cazares, Lisa H, Terzić Jovanović, Nataša, Verbić, Tatjana Ž, Andjelković, Boban, Duplantier, Allen J, Bavari, Sina, Šolaja, Bogdan A

“…The synthesis and inhibitory potencies against botulinum neurotoxin serotype A light chain (BoNT/A LC) using in vitro HPLC based enzymatic assay for various…”
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Second Generation Steroidal 4‑Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria by Videnović, Milica, Opsenica, Dejan M, Burnett, James C, Gomba, Laura, Nuss, Jonathan E, Selaković, Života, Konstantinović, Jelena, Krstić, Maja, Šegan, Sandra, Zlatović, Mario, Sciotti, Richard J, Bavari, Sina, Šolaja, Bogdan A

“…Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain…”
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Chemical Stability of the Peroxide Bond Enables Diversified Synthesis of Potent Tetraoxane Antimalarials by Opsenica, Igor, Opsenica, Dejan, Smith, Kirsten S, Milhous, Wilbur K, Šolaja, Bogdan A

“…Of 17 prepared 1,2,4,5-tetraoxacyclohexanes stable to reductive and acidic conditions, 3 of them were more active than artemisinin against CQ and MFQ resistant…”
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Novel 4-Aminoquinolines Active against Chloroquine-Resistant and Sensitive P. falciparum Strains that also Inhibit Botulinum Serotype A by Šolaja, Bogdan A, Opsenica, Dejan, Smith, Kirsten S, Milhous, Wilbur K, Terzić, Nataša, Opsenica, Igor, Burnett, James C, Nuss, Jon, Gussio, Rick, Bavari, Sina

“…We report on the initial result of the coupling of 4-amino-7-chloroquinoline with steroidal and adamantane constituents to provide small molecules with…”
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Human serum albumin binding of certain antimalarials by Marković, Olivera S., Cvijetić, Ilija N., Zlatović, Mario V., Opsenica, Igor M., Konstantinović, Jelena M., Terzić Jovanović, Nataša V., Šolaja, Bogdan A., Verbić, Tatjana Ž.

“…Interactions between eight in-house synthesized aminoquinolines, along with well-known chloroquine, and human serum albumin (HSA) have been studied by…”
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Deoxycholic Acid-Derived Tetraoxane Antimalarials and Antiproliferatives by Terzić, Nataša, Opsenica, Dejan, Milić, Dragana, Tinant, Bernard, Smith, Kirsten S, Milhous, Wilbur K, Šolaja, Bogdan A

“…The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent…”
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4‑Amino-7-chloroquinolines: Probing Ligand Efficiency Provides Botulinum Neurotoxin Serotype A Light Chain Inhibitors with Significant Antiprotozoal Activity by Opsenica, Igor M, Tot, Mikloš, Gomba, Laura, Nuss, Jonathan E, Sciotti, Richard J, Bavari, Sina, Burnett, James C, Šolaja, Bogdan A

“…Structurally simplified analogues of dual antimalarial and botulinum neurotoxin serotype A light chain (BoNT/A LC) inhibitor bis-aminoquinoline (1) were…”
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Synthesis and anti-Candida activity of novel benzothiepino[3,2-c]pyridine derivatives by Božinović, Nina, Šegan, Sandra, Vojnovic, Sandra, Pavic, Aleksandar, Šolaja, Bogdan A., Nikodinovic-Runic, Jasmina, Opsenica, Igor M.

“…A novel series of thiepine derivatives were synthesized and evaluated as potential antimicrobials. All the synthesized compounds were evaluated for their…”
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A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus by Opsenica, Igor, Burnett, James C, Gussio, Rick, Opsenica, Dejan, Todorović, Nina, Lanteri, Charlotte A, Sciotti, Richard J, Gettayacamin, Montip, Basilico, Nicoletta, Taramelli, Donatella, Nuss, Jonathan E, Wanner, Laura, Panchal, Rekha G, Šolaja, Bogdan A, Bavari, Sina

“…A 1,7-bis(alkylamino)diazachrysene-based small molecule was previously identified as an inhibitor of the botulinum neurotoxin serotype A light chain…”
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Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Mice by Konstantinović, Jelena, Videnović, Milica, Orsini, Stefania, Bogojević, Katarina, D’Alessandro, Sarah, Scaccabarozzi, Diletta, Terzić Jovanović, Nataša, Gradoni, Luigi, Basilico, Nicoletta, Šolaja, Bogdan A.

“…In this Letter, a detailed analysis of 30 4-aminoquinoline-based compounds with regard to their potential as antileishmanial drugs has been carried out. Ten…”
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Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice by Opsenica, Igor M., Verbić, Tatjana Ž., Tot, Mikloš, Sciotti, Richard J., Pybus, Brandon S., Djurković-Djaković, Olgica, Slavić, Ksenija, Šolaja, Bogdan A.

“…[Display omitted] We herein report the design and synthesis of a novel series of thiophene- and furan-based aminoquinoline derivatives which were found to be…”
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Examination of the antimalarial potential of experimental aminoquinolines: poor in vitro effect does not preclude in vivo efficacy by Srbljanović, Jelena, Štajner, Tijana, Konstantinović, Jelena, Terzić-Jovanović, Nataša, Uzelac, Aleksandra, Bobić, Branko, Šolaja, Bogdan A., Djurković-Djaković, Olgica

“…•Antimalarial efficacy of a series of 26 investigational aminoquinolines examined.•Two compounds with adamantane as a carrier cured 100% of Plasmodium…”
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Aminoquinolines afford resistance to cerebral malaria in susceptible mice by Srbljanović, Jelena, Bobić, Branko, Štajner, Tijana, Uzelac, Aleksandra, Opsenica, Igor, Terzić-Jovanović, Nataša, Bauman, Neda, Šolaja, Bogdan A., Djurković-Djaković, Olgica

“…•Excellent in vitro antimalarial efficacy of nine of ten novel aminoquinolines was shown.•Five compounds were examined for in vivo antimalarial activity.•All…”
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Antimalarial peroxides by Opsenica Dejan M., Šolaja Bogdan A.

“…The problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5-2.7…”
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Synthesis and antimicrobial activity of azepine and thiepine derivatives by Božinović Nina, Novaković Irena, Kostić-Rajačić Slađana, Opsenica Igor M., Šolaja Bogdan A.

“…A series of new 5H-pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized…”
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