Search Results - "Süssmuth, Roderich"

Bioactive Peptide Natural Products as Lead Structures for Medicinal Use by Dang, Tam, Süssmuth, Roderich D

“…The need for new drugs for the treatment of various diseases is enormous. From the previous century until the present, numerous peptide and peptide-derived…”
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Self-Assembled Monolayer Epitope Bridges for Molecular Imprinting and Cancer Biomarker Sensing by Drzazgowska, Julia, Schmid, Bianca, Süssmuth, Roderich D, Altintas, Zeynep

“…The research in biomedicine, cell signaling, diagnostics, and biocatalysis rely on selective protein binders that specifically capture a protein in a complex…”
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Venom Proteomics of Indonesian King Cobra, Ophiophagus hannah: Integrating Top-Down and Bottom-Up Approaches by Petras, Daniel, Heiss, Paul, Süssmuth, Roderich D., Calvete, Juan J.

“…We report on the first application of top-down mass spectrometry in snake venomics. De novo sequence tags generated by, and ProSight Lite supported analysis…”
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Iodine-Mediated Tryptathionine Formation Facilitates the Synthesis of Amanitins by Yao, Guiyang, Knittel, Caroline H, Kosol, Simone, Wenz, Marius T, Keller, Bettina G, Gruß, Hendrik, Braun, Alexandra C, Lutz, Christian, Hechler, Torsten, Pahl, Andreas, Süssmuth, Roderich D

“…Synthetic methods on the macrocyclization of peptides are of high interest since they facilitate the synthesis of various types of potentially bioactive…”
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Unlocking the Spatial Control of Secondary Metabolism Uncovers Hidden Natural Product Diversity in Nostoc punctiforme by Dehm, Daniel, Krumbholz, Julia, Baunach, Martin, Wiebach, Vincent, Hinrichs, Katrin, Guljamow, Arthur, Tabuchi, Takeshi, Jenke-Kodama, Holger, Süssmuth, Roderich D, Dittmann, Elke

“…Filamentous cyanobacteria belong to the most prolific producers of structurally unique and biologically active natural products, yet the majority of…”
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Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS by Meyer, Sabine, Kehr, Jan-Christoph, Mainz, Andi, Dehm, Daniel, Petras, Daniel, Süssmuth, Roderich D, Dittmann, Elke

“…The cyanobacterial hepatotoxin microcystin is assembled at a non-ribosomal peptide synthetase (NRPS) complex. The enormous structural diversity of this…”
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A Self‐Sacrificing N‐Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin by Ramm, Sascha, Krawczyk, Bartlomiej, Mühlenweg, Agnes, Poch, Annette, Mösker, Eva, Süssmuth, Roderich D.

“…Research on ribosomally synthesized and posttranslationally modified peptides (RiPPs) has led to an increasing understanding of biosynthetic mechanisms, mostly…”
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Quantum Chemistry‐based Molecular Dynamics Simulations as a Tool for the Assignment of ESI‐MS/MS Spectra of Drug Molecules by Schnegotzki, Romina, Koopman, Jeroen, Grimme, Stefan, Süssmuth, Roderich D.

“…In organic mass spectrometry, fragment ions provide important information on the analyte as a central part of its structure elucidation. With increasing…”
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Spatial VenomicsCobra Venom System Reveals Spatial Differentiation of Snake Toxins by Mass Spectrometry Imaging by Hempel, Benjamin-Florian, Damm, Maik, Petras, Daniel, Kazandjian, Taline D., Szentiks, Claudia A., Fritsch, Guido, Nebrich, Grit, Casewell, Nicholas R., Klein, Oliver, Süssmuth, Roderich D.

“…Among venomous animals, toxic secretions have evolved as biochemical weapons associated with various highly specialized delivery systems on many occasions…”
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Recognition of protein biomarkers using epitope-mediated molecularly imprinted films: Histidine or cysteine modified epitopes? by Tchinda, Raoul, Tutsch, Anna, Schmid, Bianca, Süssmuth, Roderich D., Altintas, Zeynep

“…This research aims to engineer molecularly imprinted polymer (MIP)-based synthetic receptors for the molecular recognition of neuron specific enolase (NSE)…”
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Does Bacillus velezensis Strain RP137 from the Persian Gulf Really Produce an Aminoglycoside? by Süssmuth, Roderich D., Lensch, Alexandra, Pelzer, Stefan

“…It has recently been published that an aminoglycoside, S‑137‑R, is produced by a newly isolated Bacillus velezensis strain RP137 from the Persian Gulf…”
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Overcoming AlbD Protease Resistance and Improving Potency: Synthesis and Bioactivity of Antibacterial Albicidin Analogues with Amide Bond Isosteres by Kleebauer, Leonardo, Zborovsky, Lieby, Hommernick, Kay, Seidel, Maria, Weston, John B, Süssmuth, Roderich D

“…Albicidin is a potent antibacterial oligoaromatic peptide that is susceptible to the protease AlbD, a resistance factor. This potentially restricts the use of…”
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Old World Vipers-A Review about Snake Venom Proteomics of Viperinae and Their Variations by Damm, Maik, Hempel, Benjamin-Florian, Süssmuth, Roderich D

“…Fine-tuned by millions of years of evolution, snake venoms have frightened but also fascinated humanity and nowadays they constitute potential resources for…”
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The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications by Férir, Geoffrey, Petrova, Mariya I, Andrei, Graciela, Huskens, Dana, Hoorelbeke, Bart, Snoeck, Robert, Vanderleyden, Jos, Balzarini, Jan, Bartoschek, Stefan, Brönstrup, Mark, Süssmuth, Roderich D, Schols, Dominique

“…Lantibiotics are peptides, produced by bacteria, that contain the noncanonical amino acid lanthionine and many of them exhibit antibacterial activities. The…”
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The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides by Wiebach, Vincent, Mainz, Andi, Siegert, Mary-Ann J., Jungmann, Natalia A., Lesquame, Guillaume, Tirat, Sophie, Dreux-Zigha, Assia, Aszodi, Jozsef, Le Beller, Dominique, Süssmuth, Roderich D.

“…The potent antibacterial lanthipeptide microvionin, isolated from a culture of Microbacterium arborescens , exhibits a new triamino-dicarboxylic acid moiety,…”
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Plantazolicin, a Novel Microcin B17/Streptolysin S-Like Natural Product from Bacillus amyloliquefaciens FZB42 by SCHOLZ, Romy, MOLOHON, Katie J, NACHTIGALL, Jonny, VATER, Joachim, MARKLEY, Andrew L, SÜSSMUTH, Roderich D, MITCHELL, Douglas A, BORRISS, Rainer

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Total Synthesis and Biological Assessment of Novel Albicidins Discovered by Mass Spectrometric Networking by von Eckardstein, Leonard, Petras, Daniel, Dang, Tam, Cociancich, Stéphane, Sabri, Souhir, Grätz, Stefan, Kerwat, Dennis, Seidel, Maria, Pesic, Alexander, Dorrestein, Pieter C., Royer, Monique, Weston, John B., Süssmuth, Roderich D.

“…Natural products represent an important source of potential novel antimicrobial drug leads. Low production by microorganisms in cell culture often delays the…”
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Total Synthesis and Biological Evaluation of Paenilamicins from the Honey Bee Pathogen Paenibacillus larvae by Bulatov, Timur, Gensel, Sebastian, Mainz, Andi, Dang, Tam, Koller, Timm O, Voigt, Kerstin, Ebeling, Julia, Wilson, Daniel N, Genersch, Elke, Süssmuth, Roderich D

“…Paenilamicins are a group of complex polycationic peptide secondary metabolites with antibacterial and antifungal activities produced by the devastating honey…”
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New developments in RiPP discovery, enzymology and engineering by Montalbán-López, Manuel, Scott, Thomas A, Ramesh, Sangeetha, Rahman, Imran R, van Heel, Auke J, Viel, Jakob H, Bandarian, Vahe, Dittmann, Elke, Genilloud, Olga, Goto, Yuki, Grande Burgos, María José, Hill, Colin, Kim, Seokhee, Koehnke, Jesko, Latham, John A, Link, A James, Martínez, Beatriz, Nair, Satish K, Nicolet, Yvain, Rebuffat, Sylvie, Sahl, Hans-Georg, Sareen, Dipti, Schmidt, Eric W, Schmitt, Lutz, Severinov, Konstantin, Süssmuth, Roderich D, Truman, Andrew W, Wang, Huan, Weng, Jing-Ke, van Wezel, Gilles P, Zhang, Qi, Zhong, Jin, Piel, Jörn, Mitchell, Douglas A, Kuipers, Oscar P, van der Donk, Wilfred A

“…Covering: up to June 2020Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven…”
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Hydroxy Acid Activation in Fungal Non‐Ribosomal Peptide Synthesis Assessed by Site‐Directed Mutagenesis by Hoffmann, Sylvester, Damm, Maik, Roth, Leonard, Süssmuth, Roderich D.

“…The fungal cyclodepsipeptides (CDPs) enniatin, beauvericin, bassianolide, and PF1022 consist of alternating N‐methylated l‐amino and d‐hydroxy acids. They are…”
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