Search Results - "Søvik, Oddmund"

Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry by Johansson, Bente B., Irgens, Henrik U., Molnes, Janne, Sztromwasser, Paweł, Aukrust, Ingvild, Juliusson, Petur B., Søvik, Oddmund, Levy, Shawn, Skrivarhaug, Torild, Joner, Geir, Molven, Anders, Johansson, Stefan, Njølstad, Pål R.

“…Aims/hypothesis MODY can be wrongly diagnosed as type 1 diabetes in children. We aimed to find the prevalence of MODY in a nationwide population-based registry…”
Get full text

One hundred years of insulin by Søvik, Oddmund

Get full text

Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes by Molven, Anders, Ringdal, Monika, Nordbø, Anita M, Raeder, Helge, Støy, Julie, Lipkind, Gregory M, Steiner, Donald F, Philipson, Louis H, Bergmann, Ines, Aarskog, Dagfinn, Undlien, Dag E, Joner, Geir, Søvik, Oddmund, Bell, Graeme I, Njølstad, Pål R

“…Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes Anders Molven 1 2 , Monika Ringdal 3 4 , Anita M. Nordbø 3 4 , Helge…”
Get full text

Switching from Insulin to Oral Sulfonylureas in Patients with Diabetes Due to Kir6.2 Mutations by Pearson, Ewan R, Flechtner, Isabelle, Njølstad, Pål R, Malecki, Maciej T, Flanagan, Sarah E, Larkin, Brian, Ashcroft, Frances M, Klimes, Iwar, Codner, Ethel, Iotova, Violeta, Slingerland, Annabelle S, Shield, Julian, Robert, Jean-Jacques, Holst, Jens J, Clark, Penny M, Ellard, Sian, Søvik, Oddmund, Polak, Michel, Hattersley, Andrew T

“…The beta-cell ATP-sensitive potassium channel is made up of two subunits — SUR1 and Kir6.2 — and its normal function is critical to insulin secretion. This…”
Get full text

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction by Holm, Pål I, Sbarra, Véronique, Njølstad, Pål Rasmus, Sagen, Jørn V, Ræder, Helge, Mas, Eric, Søvik, Oddmund, Nermoen, Ingrid, Molven, Anders, Johansson, Stefan, Aksnes, Lage, Bjørkhaug, Lise, Haldorsen, Ingfrid S, Eide, Stig Å, Lombardo, Dominique, Grevle, Louise

“…Dysfunction of the exocrine pancreas is observed in diabetes, but links between concurrent exocrine and endocrine pancreatic disease and contributing genetic…”
Get full text

Familial Hyperinsulinemic Hypoglycemia Caused by a Defect in the SCHAD Enzyme of Mitochondrial Fatty Acid Oxidation by MOLVEN, Anders, MATRE, Guri E, DURAN, Marinus, WANDERS, Ronald J, RISHAUG, Unni, NJØLSTAD, Pal R, JELLUM, Egil, SØVIK, Oddmund

“…Familial Hyperinsulinemic Hypoglycemia Caused by a Defect in the SCHAD Enzyme of Mitochondrial Fatty Acid Oxidation Anders Molven 1 , Guri E. Matre 1 , Marinus…”
Get full text

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: Patient characteristics and initial response to sulfonylurea therapy by SAGEN, Jørn V, RAEDER, Helge, GLOYN, Anna L, HATTERSLEY, Andrew T, MOLVEN, Anders, SØVIK, Oddmund, NJØLSTAD, Pal R, HATHOUT, Eba, SHEHADEH, Naim, GUDMUNDSSON, Kolbeinn, BAEVRE, Halvor, ABUELO, Dianne, PHORNPHUTKUL, Chanika, MOLNES, Janne, BELL, Graeme I

“…Permanent neonatal diabetes (PND) can be caused by mutations in the transcription factors insulin promoter factor (IPF)-1, eukaryotic translation initiation…”
Get full text

The Coping Styles of Adolescents With Type 1 Diabetes Are Associated With Degree of Metabolic Control by Graue, Marit, Wentzel-Larsen, Tore, Bru, Edvin, Hanestad, Berit Rokne, Sovik, Oddmund

“…The Coping Styles of Adolescents With Type 1 Diabetes Are Associated With Degree of Metabolic Control Marit Graue , MSC 1 2 , Tore Wentzel-Larsen , MSC 3 ,…”
Get full text

Pancreatic Lipomatosis Is a Structural Marker in Nondiabetic Children With Mutations in Carboxyl-Ester Lipase by RAEDER, Helge, HALDORSEN, Ingfrid S, ERSLAND, Lars, GRFÜNER, Renate, TAXT, Torfinn, SØVIK, Oddmund, MOLVEN, Anders, NJØLSTAD, Pal R

“…Pancreatic Lipomatosis Is a Structural Marker in Nondiabetic Children With Mutations in Carboxyl-Ester Lipase Helge Ræder 1 , Ingfrid S. Haldorsen 2 , Lars…”
Get full text

Glycogenin-2 Is Dispensable for Liver Glycogen Synthesis and Glucagon-Stimulated Glucose Release by Irgens, Henrik U, Fjeld, Karianne, Johansson, Bente B, Ringdal, Monika, Immervoll, Heike, Leh, Sabine, Søvik, Oddmund, Johansson, Stefan, Molven, Anders, Njølstad, Pål R

“…Context: The synthesis of glycogen is initiated by glycogenin. In humans, glycogenin-1 is expressed ubiquitously, whereas glycogenin-2 (GN2) is highly…”
Get full text

SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity[S] by Aukrust, Ingvild, Bjørkhaug, Lise, Negahdar, Maria, Molnes, Janne, Johansson, Bente B., MÜller, Yvonne, Haas, Wilhelm, Gygi, Steven P., Søvik, Oddmund, Flatmark, Torgeir, Kulkarni, Rohit N., Njølstad, Pål R.

“…Glucokinase is the predominant hexokinase expressed in hepatocytes and pancreatic β-cells, with a pivotal role in regulating glucose-stimulated insulin…”
Get full text

Spatiotemporal Trends and Age-Period-Cohort Modeling of the Incidence of Type 1 Diabetes Among Children Aged <15 Years in Norway 1973–1982 and 1989–2003 by AAMODT, Geir, STENE, Lars C, NJOLSTAD, Pal R, SOVIK, Oddmund, JONER, Geir

“…Spatiotemporal Trends and Age-Period-Cohort Modeling of the Incidence of Type 1 Diabetes Among Children Aged <15 Years in Norway 1973–1982 and 1989–2003 Geir…”
Get full text

Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4α (HNF4A) P2 Region Are Associated With Type 2 Diabetes in Scandinavians by JOHANSSON, Stefan, RAEDER, Helge, EIDE, Stig A, MIDTHJELL, Kristian, HVEEM, Kristian, SØVIK, Oddmund, MOLVEN, Anders, NJØLSTAD, Pal Rasmus

“…Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4α (HNF4A) P2 Region Are Associated…”
Get full text

Permanent neonatal diabetes caused by glucokinase deficiency: Inborn error of the glucose-insulin signaling pathway by NJØLSTAD, Pal R, SAGEN, Jørn V, SØVIK, Oddmund, MATSCHINSKY, Franz M, BJØRKHAUG, Lise, ODILI, Stella, SHEHADEH, Naim, BAKRY, Doua, SARICI, S. Umit, ALPAY, Faruk, MOLNES, Janne, MOLVEN, Anders

“…Neonatal diabetes can be either permanent or transient. We have recently shown that permanent neonatal diabetes can result from complete deficiency of…”
Get full text

From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation by SAGEN, Jørn V, ODILI, Stella, YI HAN, GRIMSBY, Joseph, TAUB, Rebecca, MOLVEN, Anders, SØVIK, Oddmund, NJØLSTAD, Pal R, MATSCHINSKY, Franz M, BJØRKHAUG, Lise, ZELENT, Dorothy, BUETTGER, Carol, KWAGH, Jae, STANLEY, Charles, DAHL-JØRGENSEN, Knut, DE BEAUFORT, Carine, BELL, Graeme I

“…From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation Jørn V. Sagen 1 , Stella Odili 2…”
Get full text

Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity by Molnes, Janne, Teigen, Knut, Aukrust, Ingvild, Bjørkhaug, Lise, Søvik, Oddmund, Flatmark, Torgeir, Njølstad, Pål Rasmus

“…Glucokinase (GK) is the central player in glucose-stimulated insulin release from pancreatic β-cells, and catalytic activation by α-d-glucose binding has a key…”
Get full text

Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D‐glucose to the super‐open form and conformational transitions by Molnes, Janne, Bjørkhaug, Lise, Søvik, Oddmund, Njølstad, Pål R., Flatmark, Torgeir

“…α‐d‐Glucose activates glucokinase (EC 2.7.1.1) on its binding to the active site by inducing a global hysteretic conformational change. Using intrinsic…”
Get full text

Co‐occurrence of vitamin D‐dependent rickets type 1 and phenylketonuria by Søvik, Oddmund, Boman, Helge

“…Vitamin D‐dependent rickets type 1 (VDDR1) was diagnosed in a 15‐month‐old girl with well‐controlled phenylketonuria (PKU). The patient was homozygous for the…”
Get full text

GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation by Negahdar, Maria, Aukrust, Ingvild, Molnes, Janne, Solheim, Marie H., Johansson, Bente B., Sagen, Jørn V., Dahl-Jørgensen, Knut, Kulkarni, Rohit N., Søvik, Oddmund, Flatmark, Torgeir, Njølstad, Pål R., Bjørkhaug, Lise

“…•The glucokinase mutation c.823C>T generates a slightly activated protein (p.R275C).•The mutation also causes a misfolded and unstable protein (p.R275C).•The…”
Get full text

Allosteric Activation of Human Glucokinase by Free Polyubiquitin Chains and Its Ubiquitin-dependent Cotranslational Proteasomal Degradation by Bjørkhaug, Lise, Molnes, Janne, Søvik, Oddmund, Njølstad, Paål Rasmus, Flatmark, Torgeir

“…Human glucokinase (hGK) is a monomeric enzyme highly regulated in pancreatic β-cells (isoform 1) and hepatocytes (isoforms 2 and 3). Although certain cellular…”
Get full text