Search Results - "Sørensen, Lambert K"

cGAS is activated by DNA in a length‐dependent manner by Luecke, Stefanie, Holleufer, Andreas, Christensen, Maria H, Jønsson, Kasper L, Boni, Gerardo A, Sørensen, Lambert K, Johannsen, Mogens, Jakobsen, Martin R, Hartmann, Rune, Paludan, Søren R

“…Cytosolic DNA stimulates innate immune responses, including type I interferons (IFN), which have antiviral and immunomodulatory activities. Cyclic GMP‐AMP…”
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Determination of cathinones and related ephedrines in forensic whole-blood samples by liquid-chromatography–electrospray tandem mass spectrometry by Soerensen, Lambert K

“…A liquid-chromatography–tandem-mass-spectrometry method using pneumatically assisted electrospray ionisation (LC–ESI-MS/MS) was developed for the simultaneous…”
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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity by Hoffmann, Markus, Hofmann-Winkler, Heike, Smith, Joan C., Krüger, Nadine, Arora, Prerna, Sørensen, Lambert K., Søgaard, Ole S., Hasselstrøm, Jørgen Bo, Winkler, Michael, Hempel, Tim, Raich, Lluís, Olsson, Simon, Danov, Olga, Jonigk, Danny, Yamazoe, Takashi, Yamatsuta, Katsura, Mizuno, Hirotaka, Ludwig, Stephan, Noé, Frank, Kjolby, Mads, Braun, Armin, Sheltzer, Jason M., Pöhlmann, Stefan

“…Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits…”
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Determination of endogenous GHB in ante-mortem whole blood, urine, and oral fluid by LC–MS/MS: The effect of different additives and storage conditions on the stability of GHB in blood by Sørensen, Lambert K., Faldborg, Kathrine B., Andersen, Charlotte U., Hasselstrøm, Jørgen B.

“…Two challenges in detecting γ-hydroxybutyric acid (GHB) intake are its endogenous presence and in vitro production after sampling. This study developed an…”
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Determination of phthalates in milk and milk products by liquid chromatography/tandem mass spectrometry by Sorensen, Lambert K

“…A liquid chromatographic/tandem mass spectrometric method using pneumatically assisted electrospray ionisation (LC/ESI‐MS/MS) was developed for determination…”
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A validated UHPLC-MS/MS method for rapid determination of senicapoc in plasma samples by Sørensen, Lambert K., Petersen, Asbjørn, Granfeldt, Asger, Simonsen, Ulf, Hasselstrøm, Jørgen B.

“…•Phospholipids impacts the accuracy of senicapoc determinations in plasma by LC–MS/MS.•Phospholipids can be removed by SPE filtration without loss of…”
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Sensitive determination of monoamine neurotransmitters, their main metabolites and precursor amino acids in different mouse brain components by liquid chromatography–electrospray tandem mass spectrometry after selective sample clean‐up by Sørensen, Lambert K., Johannsen, Mogens

“…For the assessment of diets and supplements formulated for the treatment of phenylketonuria, a highly sensitive and selective method was developed and…”
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Sensitive Determination of Cannabinoids in Whole Blood by LC-MS-MS After Rapid Removal of Phospholipids by Filtration by Sørensen, Lambert K, Hasselstrøm, Jørgen B

“…Direct analysis of Δ9-tetrahydrocannabinol (THC) and other cannabinoids in crude acetonitrile extracts of whole blood by liquid chromatography-tandem mass…”
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Entrapment of drugs in dental calculus – Detection validation based on test results from post-mortem investigations by Sørensen, Lambert K., Hasselstrøm, Jørgen B., Larsen, Line S., Bindslev, Dorthe A.

“…•The developed UHPLC-MS/MS method applies to small samples of dental calculus.•The method quantifies 67 licit and illicit drugs and metabolites in dental…”
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The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model by Ahring, Kirsten K, Dagnæs-Hansen, Frederik, Brüel, Annemarie, Christensen, Mette, Jensen, Erik, Jensen, Thomas G, Johannsen, Mogens, Johansen, Karen S, Lund, Allan M, Madsen, Jesper G, Brøndum-Nielsen, Karen, Pedersen, Michael, Sørensen, Lambert K, Kjolby, Mads, Møller, Lisbeth B

“…Management of phenylketonuria (PKU) is mainly achieved through dietary control with limited intake of phenylalanine (Phe) from food, supplemented with low…”
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Stability of Lisdexamfetamine in Sampled Whole Blood-Implications of Sampling Tube Additives and Storage Temperature for Interpretation of Impairment by Sørensen, Lambert K, Andreasen, Mette F, Jornil, Jakob R, Andersen, Charlotte U, Hasselstrøm, Jørgen B

“…Lisdexamfetamine (LDX) is a prodrug that is enzymatically converted into dextroamphetamine (d-AMP), a central nervous system stimulant. The stability of LDX in…”
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Determination of acidic and neutral therapeutic drugs in human blood by liquid chromatography–electrospray tandem mass spectrometry by SORENSEN, Lambert K

“…Abstract A liquid chromatography–tandem mass spectrometry method using pneumatically assisted electrospray ionisation (LC–ESI-MS/MS) was developed for the…”
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Determination of camostat and its metabolites in human plasma – Preservation of samples and quantification by a validated UHPLC-MS/MS method by Sørensen, Lambert K., Hasselstrøm, Jørgen B., Gunst, Jesper D., Søgaard, Ole S., Kjolby, Mads

“…Camostat mesilate is a drug that is being repurposed for new applications such as that against COVID-19 and prostate cancer. This induces a need for the…”
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Ascorbic Acid Improves the Stability of Buprenorphine in Frozen Whole Blood Samples by Sørensen, Lambert K, Hasselstrøm, Jørgen B

“…Buprenorphine (BUP) was not long-term stable in whole blood samples preserved with fluoride citrate (FC) and fluoride oxalate (FX) mixtures when stored at…”
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Simultaneous determination of propofol and its glucuronide in whole blood by liquid chromatography–electrospray tandem mass spectrometry and the influence of sample storage conditions on the reliability of the test results by Sørensen, Lambert K., Hasselstrøm, Jørgen B.

“…•The LC–MS/MS method simultaneously determines propofol and propofol β-d-glucuronide.•The LC–MS/MS method does not require chemical modifications of the…”
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The effect of antioxidants on the long‐term stability of THC and related cannabinoids in sampled whole blood by Sørensen, Lambert K., Hasselstrøm, Jørgen B.

“…The stability of cannabinoids is complex and crucial for the assessment of impaired driving caused by cannabis. Therefore, the effect of antioxidants on the…”
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A hydrophilic interaction liquid chromatography electrospray tandem mass spectrometry method for the simultaneous determination of γ-hydroxybutyrate and its precursors in forensic whole blood by Sørensen, Lambert K, Hasselstrøm, Jørgen B

“…Abstract A liquid-chromatography–tandem-mass-spectrometry method using pneumatically assisted electrospray ionisation (LC–ESI-MS/MS) was developed for the…”
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Simultaneous determination of β-hydroxybutyrate and β-hydroxy-β-methylbutyrate in human whole blood using hydrophilic interaction liquid chromatography electrospray tandem mass spectrometry by Sørensen, Lambert K., Rittig, Nikolaj F., Holmquist, Emil F., Jørgensen, Karl Anker, Jørgensen, Jens Otto Lunde, Møller, Niels, Johannsen, Mogens

“…For the quantification of β-hydroxybutyrate (BHB) and β-hydroxy-β-methylbutyrate (HMB) in human whole blood, a method using hydrophilic interaction liquid…”
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Determination of metformin and other biguanides in forensic whole blood samples by hydrophilic interaction liquid chromatography-electrospray tandem mass spectrometry by Sørensen, Lambert K.

“…ABSTRACT Metformin is an anti‐diabetic drug in the biguanide class which also includes phenformin and buformin. Because of the potential adverse effects of the…”
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Determination of Therapeutic γ-Aminobutyric Acid Analogs in Forensic Whole Blood by Hydrophilic Interaction Liquid Chromatography-Electrospray Tandem Mass Spectrometry by Sørensen, Lambert K., Hasselstrøm, Jørgen B.

“…Vigabatrin, pregabalin, gabapentin and baclofen are γ-aminobutyric acid analogs that are used in the treatment of epileptic seizures (vigabatrin, pregabalin…”
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