Search Results - "Sørensen, Claus S"

The caspase‐activated DNase: apoptosis and beyond by Larsen, Brian D., Sørensen, Claus S.

“…Organismal development and function requires multiple and accurate signal transduction pathways to ensure that proper balance between cell proliferation,…”
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WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry by Elbæk, Camilla R, Petrosius, Valdemaras, Sørensen, Claus S

“…Precise execution of the cell division cycle is vital for all organisms. The Cyclin dependent kinases (CDKs) are the main cell cycle drivers, however, their…”
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PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response by Simhadri, Srilatha, Vincelli, Gabriele, Huo, Yanying, Misenko, Sarah, Foo, Tzeh Keong, Ahlskog, Johanna, Sørensen, Claus S., Oakley, Gregory G., Ganesan, Shridar, Bunting, Samuel F., Xia, Bing

“…The G2/M checkpoint inhibits mitotic entry upon DNA damage, thereby preventing segregation of broken chromosomes and preserving genome stability. The tumor…”
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Self-inflicted DNA breaks in cell differentiation and cancer by Benada, Jan, Alsowaida, Dalal, Megeney, Lynn A., Sørensen, Claus S.

“…Nucleases are employed physiologically to inflict DNA lesions that promote processes such as apoptosis, the evolution of the germline, and adaptation of the…”
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ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function by Ahlskog, Johanna K, Larsen, Brian D, Achanta, Kavya, Sørensen, Claus S

“…DNA damage activates the ATM and ATR kinases that coordinate checkpoint and DNA repair pathways. An essential step in homology‐directed repair (HDR) of DNA…”
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Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes by Shoaib, Muhammad, Chen, Qinming, Shi, Xiangyan, Nair, Nidhi, Prasanna, Chinmayi, Yang, Renliang, Walter, David, Frederiksen, Klaus S., Einarsson, Hjorleifur, Svensson, J. Peter, Liu, Chuan Fa, Ekwall, Karl, Lerdrup, Mads, Nordenskiöld, Lars, Sørensen, Claus S.

“…Histone lysine methylations have primarily been linked to selective recruitment of reader or effector proteins that subsequently modify chromatin regions and…”
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Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing by Shoaib, Muhammad, Walter, David, Gillespie, Peter J., Izard, Fanny, Fahrenkrog, Birthe, Lleres, David, Lerdrup, Mads, Johansen, Jens Vilstrup, Hansen, Klaus, Julien, Eric, Blow, J. Julian, Sørensen, Claus S.

“…The decompaction and re-establishment of chromatin organization immediately after mitosis is essential for genome regulation. Mechanisms underlying chromatin…”
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Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability by Zarrizi, Reihaneh, Higgs, Martin R, Voßgröne, Karolin, Rossing, Maria, Bertelsen, Birgitte, Bose, Muthiah, Kousholt, Arne Nedergaard, Rösner, Heike, Network, The Complexo, Ejlertsen, Bent, Stewart, Grant S, Nielsen, Finn Cilius, Sørensen, Claus S

“…Haploinsufficiency of factors governing genome stability underlies hereditary breast and ovarian cancer. One significant pathway that is disabled as a result…”
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Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress by Larsen, Brian D, Benada, Jan, Yung, Philip Yuk Kwong, Bell, Ryan A V, Pappas, George, Urban, Vaclav, Ahlskog, Johanna K, Kuo, Tia T, Janscak, Pavel, Megeney, Lynn A, Elsässer, Simon J, Bartek, Jiri, Sørensen, Claus S

“…Genotoxic therapy such as radiation serves as a frontline cancer treatment, yet acquired resistance that leads to tumor reoccurrence is frequent. We found that…”
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DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation by Kwon, Youngho, Rösner, Heike, Zhao, Weixing, Selemenakis, Platon, He, Zhuoling, Kawale, Ajinkya S., Katz, Jeffrey N., Rogers, Cody M., Neal, Francisco E., Badamchi Shabestari, Aida, Petrosius, Valdemaras, Singh, Akhilesh K., Joel, Marina Z., Lu, Lucy, Holloway, Stephen P., Burma, Sandeep, Mukherjee, Bipasha, Hromas, Robert, Mazin, Alexander, Wiese, Claudia, Sørensen, Claus S., Sung, Patrick

“…The tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed DNA replication…”
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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours by Dibitetto, Diego, Liptay, Martin, Vivalda, Francesca, Dogan, Hülya, Gogola, Ewa, González Fernández, Martín, Duarte, Alexandra, Schmid, Jonas A., Decollogny, Morgane, Francica, Paola, Przetocka, Sara, Durant, Stephen T., Forment, Josep V., Klebic, Ismar, Siffert, Myriam, de Bruijn, Roebi, Kousholt, Arne N., Marti, Nicole A., Dettwiler, Martina, Sørensen, Claus S., Tille, Jean-Christophe, Undurraga, Manuela, Labidi-Galy, Intidhar, Lopes, Massimo, Sartori, Alessandro A., Jonkers, Jos, Rottenberg, Sven

“…Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs). In response to DNA damage, H2AX becomes…”
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E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1) by Hsu, Jerry Y, Reimann, Julie D R, Sørensen, Claus S, Lukas, Jiri, Jackson, Peter K

“…Emi1 promotes mitotic entry in Xenopus laevis embryos by inhibiting the APC(Cdc20) ubiquitination complex to allow accumulation of cyclin B. We show here that…”
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E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1 by Hsu, Jerry Y, Reimann, Julie D.R, Sorensen, Claus S, Lukas, Jiri, Jackson, Peter K

“…Emi1 promotes mitotic entry in Xenopus laevis embryos by inhibiting the APC(Cdc20) ubiquitination complex to allow accumulation of cyclin B. We show here that…”
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The caspase‐activated DN ase: apoptosis and beyond by Larsen, Brian D., Sørensen, Claus S.

“…Organismal development and function requires multiple and accurate signal transduction pathways to ensure that proper balance between cell proliferation,…”
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ATM / ATR ‐mediated phosphorylation of PALB 2 promotes RAD 51 function by Ahlskog, Johanna K, Larsen, Brian D, Achanta, Kavya, Sørensen, Claus S

“…Abstract DNA damage activates the ATM and ATR kinases that coordinate checkpoint and DNA repair pathways. An essential step in homology‐directed repair ( HDR )…”
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Deregulation of the RB pathway in human testicular germ cell tumours by Bartkova, Jirina, Lukas, Claudia, Sørensen, Claus S, Meyts, Ewa Rajpert-De, Skakkebæk, Niels E, Lukas, Jiri, Bartek, Jiri

“…Deregulation of the RB pathway is shared by most human malignancies. Components upstream of the retinoblastoma tumour suppressor (pRB), namely the INK4 family…”
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E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC Cdh1 by Jackson, Peter K, Hsu, Jerry Y, Reimann, Julie D.R, Sørensen, Claus S, Lukas, Jiri

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p16INK4a, but not constitutively active pRB, can impose a sustained G1 arrest : molecular mechanisms and implications for oncogenesis by LUKAS, J, SØRENSEN, C. S, LUKAS, C, SANTONI-RUGIU, E, BARTEK, J

“…p16ink4 and pRb, two components of a key G1/S regulatory pathway, and tumor suppressors commonly targeted in oncogenesis, are among the candidates for gene…”
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