Search Results - "Sønderstrup, Grete"

Pathogenic IgG antibodies against desmoglein 3 in pemphigus vulgaris are regulated by HLA-DRB104:02-restricted T cells by Eming, Rüdiger, Hennerici, Tina, Bäcklund, Johan, Feliciani, Claudio, Visconti, Kevin C, Willenborg, Sebastian, Wohde, Jessica, Holmdahl, Rikard, Sønderstrup, Grete, Hertl, Michael

“…Pemphigus vulgaris (PV) is considered as a model for an autoantibody-mediated organ-specific autoimmune disorder. IgG autoantibodies directed against the…”
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DRB10401-Restricted Human T Cell Clone Specific for the Major Proinsulin73-90 Epitope Expresses a Down-Regulatory T Helper 2 Phenotype by Durinovic-Belló, Ivana, Rosinger, Silke, Olson, Jennifer A., Congia, Mauro, Ahmad, Regina C., Rickert, Mathias, Hampl, Johannes, Kalbacher, Hubert, Drijfhout, Jan W., Mellins, Elizabeth D., Al Dahouk, Sascha, Kamradt, Thomas, Maeurer, Markus J., Nhan, Carol, Roep, Bart O., Boehm, Bernhard O., Polychronakos, Constantin, Nepom, Gerald T., Karges, Wolfram, McDevitt, Hugh O., Sønderstrup, Grete

“…Recently, we have identified proinsulin $(P-Ins)_{73-90}$ as an immunodominant T cell epitope of HLA-DRB1*0401 (DR4) subjects with β-islet cell autoimmunity…”
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Human Risk Allele HLA-DRB10405 Predisposes Class II Transgenic Ab0 NOD Mice to Autoimmune Pancreatitis by Freitag, Tobias L, Cham, Candace, Sung, Hsiang–Hsuan, Beilhack, Georg F, Durinovic–Belló, Ivana, Patel, Salil D, Bronson, Roderick T, Schuppan, Detlef, Sønderstrup, Grete

“…Background & Aims Autoimmune pancreatitis (AIP) underlies 5%−11% of cases of chronic pancreatitis. An association between AIP and the human leukocyte antigen…”
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Aberrant MHC Class II Expression in Mouse Joints Leads to Arthritis with Extraarticular Manifestations Similar to Rheumatoid Arthritis by Kanazawa, Satoshi, Ota, Shusuke, Sekine, Chiyoko, Tada, Toyohiro, Otsuka, Takanobu, Okamoto, Takashi, Sønderstrup, Grete, Peterlin, B. Matija

“…Genetic susceptibility to rheumatoid arthritis (RA) is associated with certain MHC class II molecules. To clarify the role of these determinants in RA, we…”
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Antigen microarray profiling of autoantibodies in rheumatoid arthritis by Hueber, Wolfgang, Kidd, Brian A., Tomooka, Beren H., Lee, Byung J., Bruce, Bonnie, Fries, James F., Sønderstrup, Grete, Monach, Paul, Drijfhout, Jan W., van Venrooij, Walther J., Utz, Paul J., Genovese, Mark C., Robinson, William H.

“…Objective Because rheumatoid arthritis (RA) is a heterogeneous autoimmune disease in terms of disease manifestations, clinical outcomes, and therapeutic…”
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Allergen-Specific MHC Class II Tetramer+ Cells Are Detectable in Allergic, but Not in Nonallergic, Individuals by Macaubas, Claudia, Wahlstrom, Jan, Galvao da Silva, Ana Paula, Forsthuber, Thomas G, Sonderstrup, Grete, Kwok, William W, DeKruyff, Rosemarie H, Umetsu, Dale T

“…Allergen-specific cells are present in very low frequency in peripheral blood of humans, and differ in function in allergic and nonallergic individuals. We…”
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Human Telomerase Reverse Transcriptase-Specific T-Helper Responses Induced by Promiscuous Major Histocompatibility Complex Class II-Restricted Epitopes by SCHROERS, Roland, LEI SHEN, ROLLINS, Lisa, ROONEY, Cliona M, SLAWIN, Kevin, SONDERSTRUP, Grete, HUANG, Xue F, CHEN, Si-Yi

“…An effective tumor vaccine may require the induction of both CTL and T-helper (Th) cell responses against tumor-associated antigens. Human telomerase reverse…”
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HLA class II transgenic mice: how closely do they reproduce human CD4 T-cell immune responses? by Sonderstrup, Grete, Durinovic-Bello, Ivana

“…Introduction: The HLA class II transgenic mouse model is designed to provide an experimental in vivo animal model in which certain aspects of human CD4 T-cell…”
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T Cell Epitopes of Insulin Defined in HLA-DR4 Transgenic Mice are Derived from Preproinsulin and Proinsulin by Congia, Mauro, Patel, Salil, Cope, Andrew P., De Virgiliis, Stefano, Sonderstrup, Grete

“…Approximately one-half of Caucasians with newly diagnosed insulin-dependent diabetes mellitus (IDDM) have autoantibodies to insulin, and the majority of those…”
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Suppressive Effect of Glutamic Acid Decarboxylase 65-Specific Autoimmune B Lymphocytes on Processing of T Cell Determinants Located Within the Antibody Epitope by Jaume, Juan Carlos, Parry, Sarah Louise, Madec, Anne-Marie, Sonderstrup, Grete, Baekkeskov, Steinunn

“…Type 1 diabetes is a T cell-mediated disease in which B cells serve critical Ag-presenting functions. In >95% of type 1 diabetic patients the B cell response…”
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Definition of MHC and T Cell Receptor Contacts in the HLA-DR4-Restricted Immunodominant Epitope in Type II Collagen and Characterization of Collagen-Induced Arthritis in HLA-DR4 and Human CD4 Transgenic Mice by Andersson, Ellen Christina, Hansen, Bjarke Endel, Jacobsen, Helle, Madsen, Lars S., Andersen, Claus B., Engberg, Jan, Rothbard, Jonathan B., McDevitt, Grete Sonderstrup, Malmstrom, Vivianne, Holmdahl, Rikard, Svejgaard, Arne, Fugger, Lars

“…Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II…”
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Identification of MHC Class II-restricted T-cell Epitopes in Prostate-specific Membrane Antigen by Schroers, Roland, Shen, Lei, Rollins, Lisa, Xiao, Zhen, Sonderstrup, Grete, Slawin, Kevin, Huang, Xue F, Chen, Si-Yi

“…An effective tumor vaccine may be required to induce both CTLs and T-helper (Th) responses against tumor-associated antigens. CD4+ Th cells that recognize MHC…”
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Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice by Andersson, Ellen Christina, Hansen, Bjarke Endel, Jacobsen, Helle, Madsen, Lars S., Andersen, Claus B., Engberg, Jan, Rothbard, Jonathan B., McDevitt, Grete Sønderstrup, Malmström, Vivianne, Holmdahl, Rikard, Svejgaard, Arne, Fugger, Lars

“…Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II…”
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Relationship between kinetic stability and immunogenicity of HLA‐DR4/peptide complexes by Hall, Frances C., Rabinowitz, Joshua D., Busch, Robert, Visconti, Kevin C., Belmares, Michael, Patil, Namrata S., Cope, Andrew P., Patel, Salil, McConnell, Harden M., Mellins, Elizabeth D., Sonderstrup, Grete

“…Immunodominant T cell epitopes from the autoantigen human cartilage glycoprotein 39 have previously been mapped in the context of HLA‐DR*0401 and *0402, using…”
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DR, DQ, and you: MHC alleles and autoimmunity by Sønderstrup, G, McDevitt, H O

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Humanized mice as a model for rheumatoid arthritis by Eming, Rüdiger, Visconti, Kevin, Hall, Frances, Sekine, Chiyoko, Kobayashi, Kayta, Chen, Qun, Cope, Andrew, Kanazawa, Satoshi, Peterlin, Matija, Rijnders, Antonius, Boots, Annemieke, Meijerink, Jan, Sønderstrup, Grete

“…Genetic susceptibility to rheumatoid arthritis (RA), a common autoimmune disease, is associated with certain HLA-DR4 alleles. Treatments are rarely curative…”
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Expression of HLA-DR4 and Human CD4 Transgenes in Mice Determines the Variable Region β-Chain T-Cell Repertoire and Mediates an HLA-DR-Restricted Immune Response by Fugger, Lars, Michie, Sara A., Rulifson, Ingrid, Lock, Christopher B., McDevitt, Grete Sonderstrup

“…Inherited susceptibility to rheumatoid arthritis is associated with genes encoding the human major histocompatibility complex class II molecule HLA-DR4. To…”
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Identification of Immunodominant T Cell Epitopes of Human Glutamic Acid Decarboxylase 65 by Using HLA-DR (α 10101,β 10401) Transgenic Mice by Patel, Salil D., Cope, Andrew P., Congia, Mauro, Chen, Teddy T., Kim, Eugene, Fugger, Lars, Wherrett, Diane, Sonderstrup-McDevitt, Grete

“…Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM…”
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Development of humanized mice as a model of inflammatory arthritis by Sønderstrup, Grete

“…Clinically, rheumatoid arthritis (RA) is a chronic deforming disease characterized mainly by joint swelling and destruction. Although synovial inflammation and…”
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Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris by Schmidt, Thomas, Willenborg, Sebastian, Hünig, Thomas, Deeg, Cornelia A., Sonderstrup, Grete, Hertl, Michael, Eming, Rüdiger

“…Pemphigus vulgaris (PV) is a potentially life‐threatening autoimmune disease of the skin and mucous membranes. Its pathogenesis is based on IgG autoantibodies…”
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