Search Results - "Sønderby, Pernille"

A head-to-head comparison of polymer interaction with mucin from porcine stomach and bovine submaxillary glands by Stie, Mai Bay, Cunha, Cristiana, Huang, Zheng, Kirkensgaard, Jacob Judas Kain, Tuelung, Pernille Sønderby, Wan, Feng, Nielsen, Hanne Mørck, Foderà, Vito, Rønholt, Stine

“…Native mucus is heterogeneous, displays high inter-individual variation and is prone to changes during harvesting and storage. To overcome the lack of…”
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Targeting NOX2 with Bivalent Small-Molecule p47phox–p22phox Inhibitors by Zang, Jie, Peters, Felix, Cambet, Yves, Cifuentes-Pagano, Eugenia, Hissabu, Munira Mohamed Shishay, Dustin, Christopher M., Svensson, Lars Henrik, Olesen, Martin Mariboe, Poulsen, Mathias Feldt Lomholt, Jacobsen, Stig, Tuelung, Pernille Sønderby, Narayanan, Dilip, Langkilde, Annette Eva, Gajhede, Michael, Pagano, Patrick J., Jaquet, Vincent, Vilhardt, Frederik, Bach, Anders

“…Nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2) is an enzymatic complex whose function is the regulated generation of reactive oxygen…”
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Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations by Frederiksen, Tine M., Sønderby, Pernille, Ryberg, Line A., Harris, Pernille, Bukrinski, Jens T., Scharff-Poulsen, Anne M., Elf-Lind, Maria N., Peters, Günther H.

“…The glucagon-like peptide 1 (GLP-1) analog, liraglutide, is a GLP-1 agonist and is used in the treatment of type-2 diabetes mellitus and obesity. From a…”
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A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3 by Hackney, Celeste M, Flórez Salcedo, Paula, Mueller, Emilie, Koch, Thomas Lund, Kjelgaard, Lau D, Watkins, Maren, Zachariassen, Linda G, Tuelung, Pernille Sønderby, McArthur, Jeffrey R, Adams, David J, Kristensen, Anders S, Olivera, Baldomero, Finol-Urdaneta, Rocio K, Safavi-Hemami, Helena, Morth, Jens Preben, Ellgaard, Lars

“…Animal venom peptides represent valuable compounds for biomedical exploration. The venoms of marine cone snails constitute a particularly rich source of…”
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Insulin fibrillation: The influence and coordination of Zn2 by Frankær, Christian Grundahl, Sønderby, Pernille, Bang, Maria Blanner, Mateiu, Ramona Valentina, Groenning, Minna, Bukrinski, Jens, Harris, Pernille

“…Protein amyloid fibrillation is obtaining much focus because it is connected with amyloid-related human diseases such as Alzheimer’s disease, diabetes mellitus…”
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Albumin-neprilysin fusion protein: understanding stability using small angle X-ray scattering and molecular dynamic simulations by Kulakova, Alina, Indrakumar, Sowmya, Sønderby Tuelung, Pernille, Mahapatra, Sujata, Streicher, Werner W., Peters, Günther H. J., Harris, Pernille

“…Fusion technology is widely used in protein-drug development to increase activity, stability, and bioavailability of protein therapeutics. Fusion proteins,…”
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Investigations of Albumin–Insulin Detemir Complexes Using Molecular Dynamics Simulations and Free Energy Calculations by Ryberg, Line A, Sønderby, Pernille, Bukrinski, Jens T, Harris, Pernille, Peters, Günther H. J

“…Insulin detemir is a lipidated insulin analogue that obtains a half-life extension by oligomerization and reversible binding to human serum albumin. In the…”
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Solution structures of long‐acting insulin analogues and their complexes with albumin by Ryberg, Line A., Sønderby, Pernille, Barrientos, Fabian, Bukrinski, Jens T., Peters, Günther H. J., Harris, Pernille

“…The lipidation of peptide drugs is one strategy to obtain extended half‐lives, enabling once‐daily or even less frequent injections for patients. The half‐life…”
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Glucagon-like Peptide 1 Conjugated to Recombinant Human Serum Albumin Variants with Modified Neonatal Fc Receptor Binding Properties. Impact on Molecular Structure and Half-Life by Bukrinski, Jens T, Sønderby, Pernille, Antunes, Filipa, Andersen, Birgitte, Schmidt, Esben G. W, Peters, Günther H. J, Harris, Pernille

“…Glucagon-like peptide 1 (GLP-1) is a small incretin hormone stimulated by food intake, resulting in an amplification of the insulin response. Though GLP-1 is…”
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Small-Angle X‑ray Scattering Data in Combination with RosettaDock Improves the Docking Energy Landscape by Sønderby, Pernille, Rinnan, Åsmund, Madsen, Jesper J, Harris, Pernille, Bukrinski, Jens T, Peters, Günther H. J

“…We have performed a benchmark to evaluate the relative success of using small-angle X-ray scattering (SAXS) data as constraints (hereafter termed…”
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Self-Interaction of Human Serum Albumin: A Formulation Perspective by Sønderby, Pernille, Bukrinski, Jens T, Hebditch, Max, Peters, Günther H. J, Curtis, Robin A, Harris, Pernille

“…In the present study, small-angle X-ray scattering (SAXS) and static light scattering (SLS) have been used to study the solution properties and…”
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Small angle X-ray scattering and molecular dynamic simulations provide molecular insight for stability of recombinant human transferrin by Kulakova, Alina, Indrakumar, Sowmya, Sønderby, Pernille, Gentiluomo, Lorenzo, Streicher, Werner, Roessner, Dierk, Frieß, Wolfgang, Peters, Günther H.J., Harris, Pernille

“…[Display omitted] •Combination of SAXS and MD simulations can explain the molecular background for the stability studies.•Destabilizing excipients in general…”
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Concentrated protein solutions investigated using acoustic levitation and small‐angle X‐ray scattering by Sønderby, Pernille, Söderberg, Christopher, Frankær, Christian G., Peters, Günther, Bukrinski, Jens T., Labrador, Ana, Plivelic, Tomás S., Harris, Pernille

“…An acoustically levitated droplet has been used to collect synchrotron SAXS data on human serum albumin protein solutions up to a protein concentration of 400…”
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The Intrinsically Disordered RNR Inhibitor Sml1 Is a Dynamic Dimer by Danielsson, Jens, Liljedahl, Leena, Bárány-Wallje, Elsa, Sønderby, Pernille, Kristensen, Line Hyltoft, Martinez-Yamout, Maria A, Dyson, H. Jane, Wright, Peter E, Poulsen, Flemming M, Mäler, Lena, Gräslund, Astrid, Kragelund, Birthe B

“…Sml1 is a small ribonucleotide reductase (RNR) regulatory protein in Saccharomyces cerevisiae that binds to and inhibits RNR activation. NMR studies of…”
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Insulin fibrillation: The influence and coordination of Zn 2 by Frankær, Christian Grundahl, Sønderby, Pernille, Bang, Maria Blanner, Mateiu, Ramona Valentina, Groenning, Minna, Bukrinski, Jens, Harris, Pernille

“…Protein amyloid fibrillation is obtaining much focus because it is connected with amyloid-related human diseases such as Alzheimer's disease, diabetes mellitus…”
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Combining SAXS with Rosetta for Identification of Native-like Protein Complexes by Sønderby, Pernille, Peters, Günther, Bukrinski, Jens, Harris, Pernille

“…Abstract only It is well-known that recombinant human serum albumin (rHSA) has the ability to stabilize proteins in solution preventing protein adsorption,…”
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