Search Results - "Söderlund, E J"

Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris(2,3-dibromopropyl)phosphate in Salmonella TA100 expressing human glutathione S-transferases by Simula, T P, Glancey, M J, Söderlund, E J, Dybing, E, Wolf, C R

“…We have expressed human glutathione S-transferases GSTA1-1 and GSTP1-1 in Salmonella typhimurium TA100 in order to assess the ability of these enzymes to…”
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A comparative study of chemically induced DNA damage in isolated human and rat testicular cells by Bjørge, Christine, Brunborg, Gunnar, Wiger, Richard, Holme, Jørn A., Scholz, Tim, Dybing, Erik, J. Søderlund, Erik

“…Testicular cells prepared from human organ transplant donors or from Wistar rats were used to compare 15 known reproductive toxicants with respect to their…”
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Situations with Enhanced Chemical Risks Due to Toxicokinetic and Toxicodynamic Factors by Dybing, Erik, Søderlund, Erik J.

“…Recognizing toxicokinetic and toxicodynamic variability is important in risk assessment of chemicals and may help to explain interindividual differences in…”
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Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite by Holme, J A, Wallin, H, Brunborg, G, Søderlund, E J, Hongslo, J K, Alexander, J

“…Hepatocytes isolated from Aroclor 1254 (PCB) pretreated rats metabolized 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to a reactive metabolite that…”
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In vitro toxicity of 1,2-dibromo-3-chloropropane (DBCP) in different testicular cell types from rats by Bjørge, Christine, Wiger, Richard, Holme, Jørn A., Brunborg, Gunnar, Andersen, Rolf, Dybing, Erik, Søderlund, Erik J.

“…1,2-Dibromo-3-chloropropane (DBCP)-induced toxicity was studied in rat germ cells from different stages of spermatogenesis, separated by centrifugal…”
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DNA Strand breaks in testicular cells from humans and rats following in vitro exposure to 1,2-dibromo-3-chloropropane (DBCP) by Bjørge, Christine, Wiger, Richard, Holme, Jørn A., Brunborg, Gunnar, Scholz, Tim, Dyeing, Erik, Søderlund, Erik J.

“…Preparations of testicular cells from human organ transplant donors and from Wistar rats were compared with respect to their composition of the different…”
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Single-strand breaks, cell cycle arrest and apoptosis in HL-60 and LLCPK1 cells exposed to 1,2-dibromo-3-chloropropane by WIGER, R, HOLME, J. A, HONGSLO, J. K, BRUNBORG, G, HAUG, K, RODILLA, V, DYBING, E, SØDERLUND, E. J

“…We investigated 1,2-dibromo-3-chloropropane (DBCP)-induced DNA damage, cell cycle alterations and cell death in two cell lines, the human leukemia HL-60 and…”
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The role of oxidative and conjugative pathways in the activation of 1,2-dibromo-3-chloropropane to DNA-damaging products in rat testicular cells by Omichinski, J G, Brunborg, G, Holme, J A, Søderlund, E J, Nelson, S D, Dybing, E

“…The ability of 1,2-dibromo-3-chloropropane (DBCP), several methylated analogs of DBCP and perdeuterated DBCP (DBCP-D5) to cause DNA damage in isolated…”
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Mutagenic activity of halogenated propanes and propenes: effect of bromine and chlorine positioning by Låg, M, Omichinski, J G, Dybing, E, Nelson, S D, Søderlund, E J

“…A series of halogenated propanes and propenes were studied for mutagenic effects in Salmonella typhimurium TA100 in the absence or presence of NADPH plus liver…”
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Metabolic activation of 1,2-dibromo-3-chloropropane: evidence for the formation of reactive episulfonium ion intermediates by Pearson, Paul G, Soderlund, Erik J, Dybing, Erik, Nelson, Sidney D

“…The nematocide and soil fumigant 1,2-dibromo-3-chloropropane (DBCP) is a carcinogen and a mutagen and displays target-organ toxicity to the testes and the…”
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Genotoxicity of paracetamol in mice and rats by Hongslo, J K, Smith, C V, Brunborg, G, Søderlund, E J, Holme, J A

“…The genotoxicity of paracetamol, including covalent binding to DNA, induction of DNA single-strand breaks (SSBs), and inhibition of replicative and repair…”
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Metabolism of 1,2-dibromo-3-chloropropane by glutathione S-transferases by Søderlund, Erik J., Meyer, David J., Ketterer, Brian, Nelson, Sidney D., Dybing, Erik, Holme, Jørn A.

“…The metabolism of l,2-dibromo-3-chloropropane (DBCP), measured as the formation of water soluble metabolites and metabolites covalently bound to…”
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Effect of bromine and chlorine positioning in the induction of renal and testicular toxicity by halogenated propanes by Laag, Marit, Soederlund, Erik J, Omichinski, James G, Brunborg, Gunnar, Holme, Joern A, Dahl, Jon E, Nelson, Sidney D, Dybing, Erik

“…A series of halogenated propanes were studied for renal and testicular necrogenic effects in the rat and correlated to their ability to induce in vivo renal…”
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Detection and mechanism of formation of the potent direct-acting mutagen 2-bromoacrolein from 1,2-dibromo-3-chloropropane by Omichinski, J G, Soderlund, E J, Dybing, E, Pearson, P G, Nelson, S D

“…The nematocide 1,2-dibromo-3-chloropropane (DBCP) was converted to products which are mutagenic for Salmonella typhimurium TA 100 in the presence of rat liver…”
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Genotoxic effects of cyclopenta-fused polycyclic aromatic hydrocarbons in isolated rat hepatocytes and rabbit lung cells by Holme, J A, Bjørge, C, Søderlund, E J, Brunborg, G, Becher, R, Lag, M, Schwarze, P E, Ross, J, Nelson, G, Nesnow, S

“…Benz[j]aceanthrylene (B[j]A) and benz[l]aceanthrylene (B[l]A), two isomeric cyclopenta polycyclic aromatic hydrocarbons (CP-PAH) structurally related to…”
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Metabolism in vitro of tris(2,3-dibromopropyl)-phosphate: oxidative debromination and bis(2,3-dibromopropyl)phosphate formation as correlates of mutagenicity and covalent protein binding by Søderlund, E J, Gordon, W P, Nelson, S D, Omichinski, J G, Dybing, E

“…Tris(2,3-dibromopropyl)phosphate (Tris-BP) was found to be metabolized by liver microsomes obtained from untreated and phenobarbital-pretreated rats…”
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Metabolic activation of bromopropyl compounds by Dybing, E, Söderlund, E J, Nelson, S D

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Species differences in testicular necrosis and DNA damage, distribution and metabolism of 1,2-dibromo-3-chloropropane (DBCP) by Låg, M, Søderlund, E J, Brunborg, G, Dahl, J E, Holme, J A, Omichinski, J G, Nelson, S D, Dybing, E

“…The human testicular toxicant 1,2-dibromo-3-chloropropane (DBCP) was studied for the same end-point in 4 different species of laboratory animals. Marked…”
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Testicular necrosis and DNA damage caused by deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat by Søderlund, E J, Brunborg, G, Omichinski, J G, Holme, J A, Dahl, J E, Nelson, S D, Dybing, E

“…To study the role of metabolism in 1,2-dibromo-3-chloropropane (DBCP)-induced testicular damage in rats, selectively deuterated and methylated analogs of DBCP…”
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Organ-specific DNA damage of tris(2,3-dibromopropyl)-phosphate and its diester metabolite in the rat by Søderlund, E J, Brunborg, G, Dybing, E, Trygg, B, Nelson, S D, Holme, J A

“…The organ specificity of tris(2,3-dibromopropyl)phosphate(Tris-BP)-induced DNA damage was investigated in the rat 2 h after a single i.p. injection of 350…”
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