Search Results - "Sékaly, Rafick‐Pierre"

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals by Fromentin, Rémi, DaFonseca, Sandrina, Costiniuk, Cecilia T., El-Far, Mohamed, Procopio, Francesco Andrea, Hecht, Frederick M., Hoh, Rebecca, Deeks, Steven G., Hazuda, Daria J., Lewin, Sharon R., Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in latently infected CD4 + T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed…”
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CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART by Fromentin, Rémi, Bakeman, Wendy, Lawani, Mariam B, Khoury, Gabriela, Hartogensis, Wendy, DaFonseca, Sandrina, Killian, Marisela, Epling, Lorrie, Hoh, Rebecca, Sinclair, Elizabeth, Hecht, Frederick M, Bacchetti, Peter, Deeks, Steven G, Lewin, Sharon R, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these…”
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Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow by Lee, Jaeyop, Breton, Gaëlle, Oliveira, Thiago Yukio Kikuchi, Zhou, Yu Jerry, Aljoufi, Arafat, Puhr, Sarah, Cameron, Mark J, Sékaly, Rafick-Pierre, Nussenzweig, Michel C, Liu, Kang

“…In mice, two restricted dendritic cell (DC) progenitors, macrophage/dendritic progenitors (MDPs) and common dendritic progenitors (CDPs), demonstrate…”
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Interleukin-7 promotes HIV persistence during antiretroviral therapy by Vandergeeten, Claire, Fromentin, Rémi, DaFonseca, Sandrina, Lawani, Mariam B., Sereti, Irini, Lederman, Michael M., Ramgopal, Moti, Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in latently infected memory CD4+ T cells during antiretroviral therapy (ART). When administered to HIV-infected subjects receiving suppressive…”
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Programmed cell death-1 contributes to the establishment and maintenance of HIV-1 latency by Evans, Vanessa A, van der Sluis, Renée M, Solomon, Ajantha, Dantanarayana, Ashanti, McNeil, Catriona, Garsia, Roger, Palmer, Sarah, Fromentin, Rémi, Chomont, Nicolas, Sékaly, Rafick-Pierre, Cameron, Paul U, Lewin, Sharon R

“…OBJECTIVE:In HIV-infected individuals on antiretroviral therapy (ART), latent HIV is enriched in CD4 T cells expressing immune checkpoint molecules, in…”
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Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination by Fourati, Slim, Cristescu, Razvan, Loboda, Andrey, Talla, Aarthi, Filali, Ali, Railkar, Radha, Schaeffer, Andrea K., Favre, David, Gagnon, Dominic, Peretz, Yoav, Wang, I-Ming, Beals, Chan R., Casimiro, Danilo R., Carayannopoulos, Leonidas N., Sékaly, Rafick-Pierre

“…Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three…”
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Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4 + T Cells by Kulpa, Deanna A, Talla, Aarthi, Brehm, Jessica H, Ribeiro, Susan Pereira, Yuan, Sally, Bebin-Blackwell, Anne-Gaelle, Miller, Michael, Barnard, Richard, Deeks, Steven G, Hazuda, Daria, Chomont, Nicolas, Sékaly, Rafick-Pierre

“…During antiretroviral therapy (ART), human immunodeficiency virus type 1 (HIV-1) persists as a latent reservoir in CD4 T cell subsets in central memory (T ),…”
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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation by Sékaly, Rafick-Pierre, Chomont, Nicolas, El-Far, Mohamed, Ancuta, Petronela, Trautmann, Lydie, Procopio, Francesco A, Yassine-Diab, Bader, Boucher, Geneviève, Boulassel, Mohamed-Rachid, Ghattas, Georges, Brenchley, Jason M, Schacker, Timothy W, Hill, Brenna J, Douek, Daniel C, Routy, Jean-Pierre, Haddad, Elias K

“…Highly active antiretroviral therapy is unable to eliminate HIV infection, because the virus persists in latently infected CD4 + T cells—a so-called virus…”
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NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1-infected patients by Zhang, Chao, Song, Jin-Wen, Huang, Hui-Huang, Fan, Xing, Huang, Lei, Deng, Jian-Ning, Tu, Bo, Wang, Kun, Li, Jing, Zhou, Ming-Ju, Yang, Cui-Xian, Zhao, Qi-Wen, Yang, Tao, Wang, Li-Feng, Zhang, Ji-Yuan, Xu, Ruo-Nan, Jiao, Yan-Mei, Shi, Ming, Shao, Feng, Sékaly, Rafick-Pierre, Wang, Fu-Sheng

“…Chronic HIV-1 infection is generally characterized by progressive CD4+ T cell depletion due to direct and bystander death that is closely associated with…”
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Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination by Fourati, Slim, Tomalin, Lewis E., Mulè, Matthew P., Chawla, Daniel G., Gerritsen, Bram, Rychkov, Dmitry, Henrich, Evan, Miller, Helen E. R., Hagan, Thomas, Diray-Arce, Joann, Dunn, Patrick, Levy, Ofer, Gottardo, Raphael, Sarwal, Minnie M., Tsang, John S., Suárez-Fariñas, Mayte, Pulendran, Bali, Kleinstein, Steven H., Sékaly, Rafick-Pierre

“…Several studies have shown that the pre-vaccination immune state is associated with the antibody response to vaccination. However, the generalizability and…”
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Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine by Fourati, Slim, Ribeiro, Susan Pereira, Blasco Tavares Pereira Lopes, Filipa, Talla, Aarthi, Lefebvre, Francois, Cameron, Mark, Kaewkungwal, J., Pitisuttithum, P., Nitayaphan, S., Rerks-Ngarm, S., Kim, Jerome H., Thomas, Rasmi, Gilbert, Peter B., Tomaras, Georgia D., Koup, Richard A., Michael, Nelson L., McElrath, M. Juliana, Gottardo, Raphael, Sékaly, Rafick-Pierre

“…The RV144 vaccine trial showed reduced risk of HIV-1 acquisition by 31.2%, although mechanisms that led to protection remain poorly understood. Here we…”
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CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemness by Mutascio, Simona, Mota, Talia, Franchitti, Lavinia, Sharma, Ashish A., Willemse, Abigail, Bergstresser, Sydney N., Wang, Hong, Statzu, Maura, Tharp, Gregory K., Weiler, Jared, Sékaly, Rafick-Pierre, Bosinger, Steven E., Paiardini, Mirko, Silvestri, Guido, Jones, R. Brad, Kulpa, Deanna A.

“…HIV infection persists during antiretroviral therapy (ART) due to a reservoir of latently infected cells that harbor replication-competent virus and evade…”
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TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis by Collins, Jeffrey M, Jones, Dean P, Sharma, Ashish, Khadka, Manoj, Liu, Ken H, Kempker, Russell R, Prideaux, Brendan, Maner-Smith, Kristal, Tukvadze, Nestani, Shah, N. Sarita, Brust, James C. M, Sékaly, Rafick-Pierre, Gandhi, Neel R, Blumberg, Henry M, Ortlund, Eric A, Ziegler, Thomas R

“…The metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using…”
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A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals by Procopio, Francesco Andrea, Fromentin, Rémi, Kulpa, Deanna A., Brehm, Jessica H., Bebin, Anne-Gaelle, Strain, Matthew C., Richman, Douglas D., O'Doherty, Una, Palmer, Sarah, Hecht, Frederick M., Hoh, Rebecca, Barnard, Richard J.O., Miller, Michael D., Hazuda, Daria J., Deeks, Steven G., Sékaly, Rafick-Pierre, Chomont, Nicolas

“…Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic strategies aimed at reducing the size of the long-lived viral…”
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Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells by Moore, Kathryn M, Pelletier, Adam-Nicolas, Lapp, Stacey, Metz, Amanda, Tharp, Gregory K, Lee, Michelle, Bhasin, Swati Sharma, Bhasin, Manoj, Sékaly, Rafick-Pierre, Bosinger, Steven E, Suthar, Mehul S

“…Zika virus (ZIKV) is a mosquito-borne flavivirus that caused an epidemic in the Americas in 2016 and is linked to severe neonatal birth defects, including…”
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Selective loss of CD107a TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH over a decade of ART by Blanch-Lombarte, Oscar, Ouchi, Dan, Jimenez-Moyano, Esther, Carabelli, Julieta, Marin, Miguel Angel, Peña, Ruth, Pelletier, Adam, Talla, Aarthi, Sharma, Ashish, Dalmau, Judith, Santos, José Ramón, Sékaly, Rafick-Pierre, Clotet, Bonaventura, Prado, Julia G

“…The co-expression of inhibitory receptors (IRs) is a hallmark of CD8+ T-cell exhaustion (Tex) in people living with HIV-1 (PLWH). Understanding alterations of…”
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CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction by Peretz, Yoav, He, Zhong, Shi, Yu, Yassine-Diab, Bader, Goulet, Jean-Philippe, Bordi, Rebeka, Filali-Mouhim, Ali, Loubert, Jean-Baptiste, El-Far, Mohamed, Dupuy, Franck P, Boulassel, Mohamed Rachid, Tremblay, Cécile, Routy, Jean-Pierre, Bernard, Nicole, Balderas, Robert, Haddad, Elias K, Sékaly, Rafick-Pierre

“…Chronic viral infections lead to persistent CD8 T cell activation and functional exhaustion. Expression of programmed cell death-1 (PD-1) has been associated…”
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Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells by Youngblood, Ben, Noto, Alessandra, Porichis, Filippos, Akondy, Rama S, Ndhlovu, Zaza M, Austin, James W, Bordi, Rebeka, Procopio, Francesco A, Miura, Toshiyuki, Allen, Todd M, Sidney, John, Sette, Alessandro, Walker, Bruce D, Ahmed, Rafi, Boss, Jeremy M, Sékaly, Rafick-Pierre, Kaufmann, Daniel E

“…Ag-specific CD8 T cells play a critical role in controlling HIV infection but eventually lose antiviral functions in part because of expression and signaling…”
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Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection by Démoulins, Thomas, Baron, Marie-Laurence, Gauchat, Dominique, Kettaf, Nadia, Reed, Steven James, Charpentier, Tania, Kalinke, Ulrich, Lamarre, Alain, Ahmed, Rafi, Sékaly, Rafick-Pierre, Sarkar, Surojit, Kalia, Vandana

“…Type-I interferon (IFN-I) signals exert a critical role in disease progression during viral infections. However, the immunomodulatory mechanisms by which IFN-I…”
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Cocaine use associated gut permeability and microbial translocation in people living with HIV in the Miami Adult Study on HIV (MASH) cohort by Hernandez, Jacqueline, Tamargo, Javier A, Sales Martinez, Sabrina, Martin, Haley R, Campa, Adriana, Sékaly, Rafick-Pierre, Bordi, Rebeka, Sherman, Kenneth E, Rouster, Susan D, Meeds, Heidi L, Khalsa, Jag H, Mandler, Raul N, Lai, Shenghan, Baum, Marianna K

“…Determine if cocaine use impacts gut permeability, promotes microbial translocation and immune activation in people living with HIV (PLWH) using effective…”
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