Search Results - "Sékaly, R P"

Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV‐1 reservoirs: results from a multicentre randomized clinical study by Routy, JP, Tremblay, CL, Angel, JB, Trottier, B, Rouleau, D, Baril, JG, Harris, M, Trottier, S, Singer, J, Chomont, N, Sékaly, RP, Boulassel, MR

“…Objectives Conflicting results have been reported regarding the ability of valproic acid (VPA) to reduce the size of HIV reservoirs in patients receiving…”
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Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells by Alam, A, Cohen, L Y, Aouad, S, Sékaly, R P

“…Apoptosis induced by T cell receptor (TCR) triggering in T lymphocytes involves activation of cysteine proteases of the caspase family through their…”
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Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum by Busch, R., Cloutier, I., Sékaly, R. P., Hämmerling, G. J.

“…Unlike class I histocompatibility (MHC) antigens, most newly synthesized MHC class II molecules fail to be loaded with peptides in the endoplasmic reticulum…”
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Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study by Lévy, Y., Sereti, I., Tambussi, G., Routy, J. P., Lelièvre, J. D., Delfraissy, J. F., Molina, J. M., Fischl, M., Goujard, C., Rodriguez, B., Rouzioux, C., Avettand-Fenoël, V., Croughs, T., Beq, S., Morre, M., Poulin, J. F., Sekaly, R. P., Thiebaut, R., Lederman, M. M.

“…Background. The immune deficiency of human immunodeficiency virus (HIV) infection is not fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4…”
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Notch1 antiapoptotic activity is abrogated by caspase cleavage in dying T lymphocytes by Cohen, L Y, Bourbonnière, M, Sabbagh, L, Bouchard, A, Chew, T, Jeannequin, P, Lazure, C, Sékaly, R-P

“…Excessive signaling via the Notch1 receptor inhibits apoptosis in T lymphocytes. Since several antiapoptotic proteins are cleaved by caspases during cell…”
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Cutting Edge: Detection of Antigen-Specific CD4+ T Cells by HLA-DR1 Oligomers Is Dependent on the T Cell Activation State by Cameron, Thomas O, Cochran, Jennifer R, Yassine-Diab, Bader, Sekaly, Rafick-Pierre, Stern, Lawrence J

“…Class I MHC tetramers have proven to be invaluable tools for following and deciphering the CD8(+) T cell response, but the development of similar reagents for…”
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role of caspases in T cell development and the control of immune responses by Denis, F, Rhéaume, E, Aouad, S. M, Alam, A, Sékaly, R.-P, Cohen, L. Y

“…Apoptosis is responsible for the removal of potentially autoreactive or useless T cells during thymic selection and activated T cells in the periphery…”
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Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Rα on central and effector memory CD4⁺ and CD8⁺ T cell subsets by Mercier, F, Boulassel, M.-R, Yassine-Diab, B, Tremblay, C, Bernard, N.-F, Sekaly, R.-P, Routy, J.-P

“…Interleukin (IL)-7 and its receptor (IL-7Rα) play important roles in regulating lymphopoiesis. Previous studies have reported that human immunodeficiency…”
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Skewed maturation of memory HIV-specific CD8 T lymphocytes by Rowland-Jones, Sarah, Nobile, Massimo, Appay, Victor, Knabenhans, Christian, Rizzardi, G. Paolo, Ellefsen, Kim, Pantaleo, Giuseppe, Sékaly, Rafick-P, King, Abigail S, McMichael, Andrew J, Champagne, Patrick, Ogg, Graham S, Fleury, Sylvain, Lipp, Martin, Förster, Reinhold

“…Understanding the lineage differentiation of memory T cells is a central question in immunology. We investigated this issue by analysing the expression of the…”
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Interactions between staphylococcal superantigens and MHC class II molecules by Labrecque, N, Thibodeau, J, Sékaly, R P

“…Superantigen binding to MHC class II molecules is a prerequisite for T cell stimulation. While the presentation of superantigens is not MHC restricted, allelic…”
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OA04-05. Safety and viral load changes in HIV-1 infected subjects treated with autologous dendritic immune therapy following ART discontinuation (CTN#239) by Routy, J, Boulassel, M, Mona, L, Sylvie, V, Cécile, T, Jonathan, A, John, G, Jean-Guy, B, Fiona, S, Renu, J, Don, H, Irina, T, Charles, N, Sékaly, RP

“…Meeting abstracts - A single PDF containing all abstracts in this Supplement is available at…”
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Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology by Geenen, V, Poulin, JF, Dion, ML, Martens, H, Castermans, E, I, Hansenne, Moutschen, M, Sekaly, RP, Cheynier, R

“…Although the thymus constitutes a target organ for most protein and steroid hormones, it has been quite difficult to determine the precise control exerted in…”
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TCF-1 expression is associated with HIV-specific CD8+ T cell proliferative capacity by R. Rutishauser, C.D. Deguit, R. Hoh, M. Hough, M. Krone, R.-P. Sékaly, F.M. Hecht, C.D. Pilcher, J.N. Martin, J.M. Mccune, S.G. Deeks, P.W. Hunt

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Design and implementation of a randomized crossover study of valproic acid and antiretroviral therapy to reduce the HIV reservoir by Routy, J P, Angel, J B, Spaans, J N, Trottier, B, Rouleau, D, Baril, J G, Harris, M, Trottier, S, Singer, J, Chomont, N, Sékaly, R P, Tremblay, C L

“…HIV reservoirs represent the major obstacles for eradication and are defined as a cell type that allows persistence of replication-competent HIV in patients on…”
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T cell receptor-major histocompatibility complex class II interaction is required for the T cell response to bacterial superantigens by Labrecque, N, Thibodeau, J, Mourad, W, Sékaly, R P

“…Bacterial and retroviral superantigens (SAGs) stimulate a high proportion of T cells expressing specific variable regions of the T cell receptor (TCR) beta…”
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lck-Independent Inhibition of T Cell Antigen Response by the HIV gp120 by Gratton, Sophie, Julius, Michael, Sekaly, Rafick-Pierre

“…Binding of the HIV envelope glycoprotein gp120 to CD4 inhibits T cell activation. We have used a murine T cell clone transfected with either wild-type human…”
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Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection by Salha, M.-D, Cheynier, R, Halwani, R, McGrath, H, Langaee, T.Y, Yassine Diab, B, Fournier, J, Parenteau, M, Edgar, J, Ko, D, Sherring, A, Bogdanovic, D, Sekaly, R.-P, Rud, E.W

“…Abstract Attempts to evaluate the protective effect of live attenuated SIV vaccine strains have yielded variable results depending on the route of…”
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Learning to remember: generation and maintenance of T-cell memory by Champagne, P, Dumont, A R, Sékaly, R P

“…Immunologic memory results from a carefully coordinated interplay between cells of the immune system. In this review, we explore various aspects of the nature,…”
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Degradation of CD4 Induced by Human Immunodeficiency Virus Type 1 Vpu Protein: A Predicted Alpha-Helix Structure in the Proximal Cytoplasmic Region of CD4 Contributes to Vpu Sensitivity by Yao, Xiao-Jian, Friborg, Jacques, Checroune, Florent, Gratton, Sophie, Boisvert, Françoise, Sékaly, Rafick P., Cohen, Eric A.

“…The HIV-1-encoded Vpu protein induces a rapid and specific degradation of CD4 molecules in the endoplasmic reticulum (ER). In this study, Vpu-induced…”
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Function of the Thymus in HIV-Infected Adults by Poulin, Jean-François, Sékaly, Rafick-Pierre

“…The thymus represents the major site of the production and generation of T cells expressing αβ-type T-cell antigen receptors. Age-related involution may affect…”
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