Search Results - "Sætrom, Pål"
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An integrated expression atlas of miRNAs and their promoters in human and mouse
Published in Nature biotechnology (01-09-2017)“…An atlas of microRNA expression patterns and regulators is produced by deep sequencing of short RNAs in human and mouse cells. MicroRNAs (miRNAs) are short…”
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Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks
Published in BMC research notes (23-03-2017)“…Gene expression profiling from blood is sensitive to technology choices. For example, the main blood RNA collection systems-the PAXgene and Tempus…”
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MicroRNAs in Disease and Potential Therapeutic Applications
Published in Molecular therapy (01-12-2007)“…MicroRNAs (miRNAs) are 21–24 nucleotide (nt) duplex RNAs that are created from precursor transcripts by subsequent processing steps mediated by members of the…”
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Cell cycle regulation of human DNA repair and chromatin remodeling genes
Published in DNA repair (01-06-2015)“…•Novel database for cell cycle-regulated DNA repair and chromatin remodeling genes.•Analyses of genome wide regulation of DNA repair and chromatin remodeling…”
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MicroRNA-directed transcriptional gene silencing in mammalian cells
Published in Proceedings of the National Academy of Sciences - PNAS (21-10-2008)“…MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level in the cytoplasm, but recent findings suggest additional roles for miRNAs in the…”
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Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location
Published in BMC cancer (20-02-2019)“…MicroRNAs (miRNA) and other small RNAs are frequently dysregulated in cancer and are promising biomarkers for colon cancer. Here we profile human, virus and…”
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Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA
Published in Diabetes (New York, N.Y.) (01-12-2014)“…The mechanisms by which macrophages mediate the enhanced inflammation associated with diabetes complications are not completely understood. We used RNA…”
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Non-Coding RNAs in Human Breast Milk: A Systematic Review
Published in Frontiers in immunology (01-09-2021)“…Breast milk is the primary source of nutrition and hydration for the newborn infant but also plays an important role in the child's first immune defense…”
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Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients
Published in BMC cancer (28-10-2019)“…The expression of microRNAs (miRNAs) is a promising prognostic and diagnostic tool in hepatocellular carcinoma (HCC). Here we performed small RNA sequencing…”
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Transcriptional development of the hippocampus and the dorsal–intermediate–ventral axis in rats
Published in Hippocampus (01-09-2023)“…Risk and resilience for neuropsychiatric illnesses are established during brain development, and transcriptional markers of risk may be identifiable in early…”
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MicroRNAs – targeting and target prediction
Published in New biotechnology (31-07-2010)“…MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps…”
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RNA motif discovery: a computational overview
Published in Biology direct (09-10-2015)“…Genomic studies have greatly expanded our knowledge of structural non-coding RNAs (ncRNAs). These RNAs fold into characteristic secondary structures and…”
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Distance constraints between microRNA target sites dictate efficacy and cooperativity
Published in Nucleic acids research (01-04-2007)“…MicroRNAs (miRNAs) have the potential to regulate the expression of thousands of genes, but the mechanisms that determine whether a gene is targeted or not are…”
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Associations of gene expression in blood with BMI and weight changes among women in the Norwegian Women and Cancer postgenome cohort
Published in Obesity (Silver Spring, Md.) (01-09-2023)“…Objective This study aimed to evaluate associations between blood gene expression profiles and (1) current BMI and (2) past weight changes (WCs) among…”
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The importance of p53 pathway genetics in inherited and somatic cancer genomes
Published in Nature reviews. Cancer (01-04-2016)“…Key Points In this Analysis, we explore the possibility that commonly inherited genetic variants in the p53 pathway play a significant part in susceptibility…”
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MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases
Published in RNA (Cambridge) (01-11-2013)“…MicroRNAs (miRNAs) play a key role in regulating mRNA expression, and individual miRNAs have been proposed as diagnostic and therapeutic candidates. The…”
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Increased levels of microRNA‐320 in blood serum and plasma is associated with imminent and advanced lung cancer
Published in Molecular oncology (01-02-2023)“…Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We…”
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MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity
Published in Experimental dermatology (01-04-2022)“…MicroRNAs (miRNAs) are small non‐coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown…”
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Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α
Published in PloS one (22-12-2016)“…Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a complex interplay between T cells, dendritic cells and the epidermis in…”
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Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo
Published in Hepatology (Baltimore, Md.) (01-01-2014)“…Hepatocellular carcinoma (HCC) occurs predominantly in patients with liver cirrhosis. Here we show an innovative RNA‐based targeted approach to enhance…”
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