Search Results - "Sääf, A."

Elevated Expression and Genetic Association Links the SOCS3 Gene to Atopic Dermatitis by Ekelund, E., Sääf, A., Tengvall-Linder, M., Melen, E., Link, J., Barker, J., Reynolds, N.J., Meggitt, S.J., Kere, J., Wahlgren, C.-F., Pershagen, G., Wickman, M., Nordenskjöld, M., Kockum, I., Bradley, M.

“…In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients…”
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Are BIC (miR-155) polymorphisms associated with eczema susceptibility? by Sääf, Annika, Kockum, Ingrid, Wahlgren, Carl-Fredrik, Xu, Ning, Sonkoly, Enikö, Ståhle, Mona, Nordenskjöld, Magnus, Bradley, Maria, Pivarcsi, Andor

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Proline-induced disruption of a transmembrane α-helix in its natural environment by Nilsson, IngMarie, Sääf, Annika, Whitley, Paul, Gafvelin, Guro, Waller, Cecilia, von Heijne, Gunnar

“…α-Helix formation in globular proteins has been studied both theoretically and experimentally for decades, while a lack of both high-resolution structures and…”
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The Internal Repeats in the Na+/Ca2+Exchanger-related Escherichia coli Protein YrbG Have Opposite Membrane Topologies by Sääf, Annika, Baars, Louise, von Heijne, Gunnar

“…We have determined the topology of theEscherichia coli inner membrane protein YrbG, a putative Na+/Ca2+ exchanger with homology to a family of eukaryotic ion…”
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Differential use of the Signal Recognition Particle Translocase Targeting Pathway for Inner Membrane Protein Assembly in Escherichia coli by De Gier, Jan-Willem L., Scotti, Pier A., Saaf, Annika, Valent, Quido A., Kuhn, Andreas, Luirink, Joen, Von Heijne, Gunnar

“…Assembly of several inner membrane proteins--leader peptidase (Lep), a Lep derivative (Lep-inv) that inserts with an inverted topology compared with the…”
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Divergent Evolution of Membrane Protein Topology: The Escherichia coli RnfA and RnfE Homologues by Sääf, Annika, Johansson, Marie, Wallin, Erik, von Heijne, Gunnar

“…Although the molecular evolution of protein tertiary structure and enzymatic activity has been studied for decades, little attention has been paid to the…”
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Formation of cytoplasmic turns between two closely spaced transmembrane helices during membrane protein integration into the ER membrane by Sääf, A, Hermansson, M, von Heijne, G

“…The helical hairpin, two closely spaced transmembrane helices separated by a short turn, is a recurring structural element in integral membrane proteins, and…”
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Stop‐transfer function of pseudo‐random amino acid segments during translocation across prokaryotic and eukaryotic membranes by Sääf, Annika, Wallin, Erik, von Heijne, Gunnar

“…We have measured the efficiency of stop‐transfer function for a set of pseudo‐random, 18‐residue amino acid segments, both in Escherichia coli and in mammalian…”
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SecA-dependence of the translocation of a large periplasmic loop in the Escherichia coli MalF inner membrane protein is a function of sequence context by Sääf, A, Andersson, H, Gafvelin, G, von Heijne, G

“…We have analysed the translocation of a large periplasmic loop in the Escherichia coli MalF inner membrane protein when placed in different sequence contexts…”
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Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli by Sääf, A, Monné, M, de Gier, J W, von Heijne, G

“…We have characterized the membrane topology of a 60-kDa inner membrane protein from Escherichia coli that is homologous to the recently identified Oxa1p…”
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MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? by Sonkoly, Enikö, Wei, Tianling, Janson, Peter C J, Sääf, Annika, Lundeberg, Lena, Tengvall-Linder, Maria, Norstedt, Gunnar, Alenius, Harri, Homey, Bernhard, Scheynius, Annika, Ståhle, Mona, Pivarcsi, Andor

“…MicroRNAs are a recently discovered class of posttranscriptional regulators of gene expression with critical functions in health and disease. Psoriasis is the…”
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Membrane protein anchors and polytopic determinants by Whitley, P, Sääf, A, Gafvelin, G, Johansson, M, Wallin, E, von Heijne, G

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To be and to have a critical friend in medical teaching by Dahlgren, Lars Owe, Eriksson, Björn E, Gyllenhammar, Hans, Korkeila, Maarit, Sääf-Rothoff, Annika, Wernerson, Annika, Seeberger, Astrid

“…Background  In order to stimulate reflection and continuous professional development, a model of critical friends evaluating each other was introduced in…”
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DNA methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factors by Reinius, Lovisa E, Gref, Anna, Sääf, Annika, Acevedo, Nathalie, Joerink, Maaike, Kupczyk, Maciej, D'Amato, Mauro, Bergström, Anna, Melén, Erik, Scheynius, Annika, Dahlén, Sven-Erik, Pershagen, Göran, Söderhäll, Cilla, Kere, Juha

“…Asthma and allergy are complex disorders influenced by both inheritance and environment, a relationship that might be further clarified by epigenetics…”
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IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L by Viktorin, Alexander, Frankowiack, Marcel, Padyukov, Leonid, Chang, Zheng, Melén, Erik, Sääf, Annika, Kull, Inger, Klareskog, Lars, Hammarström, Lennart, Magnusson, Patrik K E

“…In a broad attempt to improve the understanding of the genetic regulation of serum IgA levels, the heritability was estimated in over 12 000 Swedish twins, and…”
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Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma by Acevedo, Nathalie, Sääf, Annika, Söderhäll, Cilla, Melén, Erik, Mandelin, Jami, Pietras, Christina Orsmark, Ezer, Sini, Karisola, Piia, Vendelin, Johanna, Gennäs, Gustav Boije af, Yli-Kauhaluoma, Jari, Alenius, Harri, von Mutius, Erika, Doekes, Gert, Braun-Fahrländer, Charlotte, Riedler, Josef, van Hage, Marianne, D'Amato, Mauro, Scheynius, Annika, Pershagen, Göran, Kere, Juha, Pulkkinen, Ville

“…Retinoid acid receptor-related Orphan Receptor Alpha (RORA) was recently identified as a susceptibility gene for asthma in a genome-wide association study. To…”
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Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression by Klomp, Jeff A, Petillo, David, Niemi, Natalie M, Dykema, Karl J, Chen, Jindong, Yang, Ximing J, Sääf, Annika, Zickert, Peter, Aly, Markus, Bergerheim, Ulf, Nordenskjöld, Magnus, Gad, Sophie, Giraud, Sophie, Denoux, Yves, Yonneau, Laurent, Méjean, Arnaud, Vasiliu, Viorel, Richard, Stéphane, MacKeigan, Jeffrey P, Teh, Bin T, Furge, Kyle A

“…Germline mutations in the folliculin (FLCN) gene are associated with the development of Birt-Hogg-Dubé syndrome (BHDS), a disease characterized by papular skin…”
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Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis by Liedén, Agne, Winge, Mårten C G, Sääf, Annika, Kockum, Ingrid, Ekelund, Elisabeth, Rodriguez, Elke, Fölster-Holst, Regina, Franke, Andre, Illig, Thomas, Tengvall-Linder, Maria, Baurecht, Hansjörg, Weidinger, Stephan, Wahlgren, Carl-Fredrik, Nordenskjöld, Magnus, Bradley, Maria

“…Atopic dermatitis (AD) is a common chronic inflammatory skin disorder where epidermal barrier dysfunction is a major factor in the pathogenesis. The…”
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Characterization of EGFR and ErbB2 expression in atopic dermatitis patients by Sääf, Annika, Pivarcsi, Andor, Winge, Mårten C. G., Wahlgren, Carl-Fredrik, Homey, Bernhard, Nordenskjöld, Magnus, Tengvall-Linder, Maria, Bradley, Maria

“…Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases in industrialized countries. To identify candidate genes involved in the…”
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Sec-dependent membrane protein insertion: sequential interaction of nascent FtsQ with SecY and YidC by Urbanus, Malene L, Scotti, Pier A, Fröderberg, Linda, Sääf, Annika, de Gier, Jan-Willem L, Brunner, Josef, Samuelson, James C, Dalbey, Ross E, Oudega, Bauke, Luirink, Joen

“…Recent studies identified YidC as a novel membrane factor that may play a key role in membrane insertion of inner membrane proteins (IMPs), both in conjunction…”
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