Search Results - "Sánchez‐Rodríguez, Irene"

Hippocampal long‐term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G‐protein‐gated inwardly rectifying potassium channel activity by Sánchez‐Rodríguez, Irene, Djebari, Souhail, Temprano‐Carazo, Sara, Vega‐Avelaira, David, Jiménez‐Herrera, Raquel, Iborra‐Lázaro, Guillermo, Yajeya, Javier, Jiménez‐Díaz, Lydia, Navarro‐López, Juan D.

“…Hippocampal synaptic plasticity disruption by amyloid‐β (Aβ) peptides + thought to be responsible for learning and memory impairments in Alzheimer's disease…”
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CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non‐associative learning by Iborra‐Lázaro, Guillermo, Djebari, Souhail, Sánchez‐Rodríguez, Irene, Gratacòs‐Batlle, Esther, Sánchez‐Fernández, Nuria, Radošević, Marija, Casals, Núria, Navarro‐López, Juan de Dios, Soto del Cerro, David, Jiménez‐Díaz, Lydia

“…Carnitine palmitoyltransferase 1c (CPT1C) is a neuron‐specific protein widely distributed throughout the CNS and highly expressed in discrete brain areas…”
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Recognition Memory Induces Natural LTP-like Hippocampal Synaptic Excitation and Inhibition by Sánchez-Rodríguez, Irene, Temprano-Carazo, Sara, Jeremic, Danko, Delgado-Garcia, Jose Maria, Gruart, Agnès, Navarro-López, Juan D., Jiménez-Díaz, Lydia

“…Synaptic plasticity is a cellular process involved in learning and memory by which specific patterns of neural activity adapt the synaptic strength and…”
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Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma by Kinnaman, Michael D, Zaccaria, Simone, Makohon-Moore, Alvin, Arnold, Brian, Levine, Max F, Gundem, Gunes, Arango Ossa, Juan E, Glodzik, Dominik, Rodríguez-Sánchez, M Irene, Bouvier, Nancy, Li, Shanita, Stockfisch, Emily, Dunigan, Marisa, Cobbs, Cassidy, Bhanot, Umesh K, You, Daoqi, Mullen, Katelyn, Melchor, Jerry P, Ortiz, Michael V, O'Donohue, Tara J, Slotkin, Emily K, Wexler, Leonard H, Dela Cruz, Filemon S, Hameed, Meera R, Glade Bender, Julia L, Tap, William D, Meyers, Paul A, Papaemmanuil, Elli, Kung, Andrew L, Iacobuzio-Donahue, Christine A

“…Multiple large-scale genomic profiling efforts have been undertaken in osteosarcoma to define the genomic drivers of tumorigenesis, therapeutic response, and…”
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Is There a Future for Small-Scale Cogeneration in Europe? Economic and Policy Analysis of the Internal Combustion Engine, Micro Gas Turbine and Micro Humid Air Turbine Cycles by Montero Carrero, Marina, Rodríguez Sánchez, Irene, De Paepe, Ward, Parente, Alessandro, Contino, Francesco

“…If more widely deployed, small-scale cogeneration could increase energy efficiency in Europe. Of the two main commercially available technologies—the Internal…”
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Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis by Mayordomo-Cava, Jennifer, Iborra-Lazaro, Guillermo, Djebari, Souhail, Temprano- Carazo, Sara, Sanchez-Rodriguez, Irene, Jeremic, Danko, Gruart, Agnes, Delgado-Garda, Jose Maria, Jimenez-Diaz, Lydia, Navarro-Lopez, Juan D

“…In early Alzheimer disease (AD) models synaptic failures and upstreaming aberrant patterns of network synchronous activity result in hippocampal-dependent…”
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G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice by Djebari, Souhail, Iborra-Lázaro, Guillermo, Temprano-Carazo, Sara, Sánchez-Rodríguez, Irene, Nava-Mesa, Mauricio O, Múnera, Alejandro, Gruart, Agnès, Delgado-García, José M, Jiménez-Díaz, Lydia, Navarro-López, Juan D

“…The G-protein-gated inwardly rectifying potassium (Kir3/GIRK) channel is the effector of many G-protein-coupled receptors (GPCRs). Its dysfunction has been…”
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Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology by Sánchez-Rodríguez, Irene, Temprano-Carazo, Sara, Nájera, Alberto, Djebari, Souhail, Yajeya, Javier, Gruart, Agnès, Delgado-García, José M., Jiménez-Díaz, Lydia, Navarro-López, Juan D.

“…The hippocampus plays a critical role in learning and memory. Its correct performance relies on excitatory/inhibitory synaptic transmission balance. In early…”
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Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid- β Pathology by Sánchez-Rodríguez, Irene, Gruart, Agnès, Delgado-García, José María, Jiménez-Díaz, Lydia, Navarro-López, Juan D

“…Imbalances of excitatory/inhibitory synaptic transmission occur early in the pathogenesis of Alzheimer's disease (AD), leading to hippocampal hyperexcitability…”
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NEW INSIGHTS INTO CPT1C FUNCTIONS RELATED TO LEARNING AND MEMORY: FROM SYNAPSES TO BEHAVIOR by Lázaro, Guillermo Iborra, Djebari, Souhail, Sánchez-Rodríguez, Irene, Gratacòs-Batlle, Esther, Sánchez-Fernández, Nuria, Radosevic, Marija, Casals, Nuria, Navarro-López, Juan D., Soto, David, Jiménez-Díaz, Lydia

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The Human Cytomegalovirus UL38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2 by Rodríguez-Sánchez, Irene, Schafer, Xenia L, Monaghan, Morgan, Munger, Joshua

“…Human Cytomegalovirus (HCMV) infection induces several metabolic activities that are essential for viral replication. Despite the important role that this…”
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Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism by Rodríguez-Sánchez, Irene, Munger, Joshua

“…Viruses are parasites that depend on the host cell's metabolic resources to provide the energy and molecular building blocks necessary for the production of…”
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Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose starvation by Raymonda, Matthew H, Rodríguez-Sánchez, Irene, Schafer, Xenia L, Smorodintsev-Schiller, Leonid, Harris, Isaac S, Munger, Joshua

“…Viruses modulate host cell metabolism to support the mass production of viral progeny. For human cytomegalovirus, we find that the viral U 38 protein is…”
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Replication-competent fluorescent-expressing influenza B virus by Nogales, Aitor, Rodríguez-Sánchez, Irene, Monte, Kristen, Lenschow, Deborah J., Perez, Daniel R., Martínez-Sobrido, Luis

“…•We have generated replication-competent IBV expressing fluorescent proteins.•Fluorescent-expressing IBV display similar growth kinetics than wild-type…”
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A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association by Huang, Huachao, Liu, Shuai, Jean, Maxime, Simpson, Sydney, Huang, He, Merkley, Mark, Hayashi, Tsuyoshi, Kong, Weili, Rodríguez-Sánchez, Irene, Zhang, Xiaofeng, Yosief, Hailemichael O, Miao, Hongyu, Que, Jianwen, Kobie, James J, Bradner, James, Santoso, Netty G, Zhang, Wei, Zhu, Jian

“…While combinatory antiretroviral therapy (cART) can effectively reduce HIV-1 viremia, it cannot eliminate HIV-1 infection. In the presence of cART, viral…”
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The Human Cytomegalovirus U.sub.L38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2 by Rodríguez-Sánchez, Irene, Schafer, Xenia L, Monaghan, Morgan, Munger, Joshua

“…Human Cytomegalovirus (HCMV) infection induces several metabolic activities that are essential for viral replication. Despite the important role that this…”
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Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system by Jeremic, Danko, Sanchez-Rodriguez, Irene, Jimenez-Diaz, Lydia, Navarro-Lopez, Juan D.

“…G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for maintaining resting membrane potential, cell excitability and inhibitory…”
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Characterization of hippocampal amyloidosis induced by amyloid‐ β in behaving mice: Developing topics by Iborra‐Lázaro, Guillermo, Mayordomo‐Cava, Jennifer, Sánchez‐Rodríguez, Irene, Temprano‐Carazo, Sara, Djebari, Souhail, Gruart, Agnès, Delgado‐Garcia, Jose Maria, Navarro‐López, Juan D., Jimenez‐Diaz, Lydia

“…Abstract Background In early stages of Alzheimer’s disease, disruption of learning and memory processes that rely on hippocampal performance correlates with…”
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Characterization of hippocampal amyloidosis induced by amyloid‐β in behaving mice by Iborra‐Lázaro, Guillermo, Mayordomo‐Cava, Jennifer, Sánchez‐Rodríguez, Irene, Temprano‐Carazo, Sara, Djebari, Souhail, Gruart, Agnès, Delgado‐Garcia, Jose Maria, Navarro‐López, Juan D., Jimenez‐Diaz, Lydia

“…Background In early stages of Alzheimer’s disease, disruption of learning and memory processes that rely on hippocampal performance correlates with aberrant…”
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Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling by Moreno, Jr, Isreal, Rodríguez-Sánchez, Irene, Schafer, Xenia, Munger, Joshua

“…Viruses depend on cellular metabolic resources to supply the energy and biomolecular building blocks necessary for their replication. Human cytomegalovirus…”
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