Search Results - "Sánchez‐Blázquez, Pilar"

The sigma‐1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors by Ruiz‐Cantero, M. Carmen, Cortés‐Montero, Elsa, Jain, Aakanksha, Montilla‐García, Ángeles, Bravo‐Caparrós, Inmaculada, Shim, Jaehoon, Sánchez‐Blázquez, Pilar, Woolf, Clifford J., Baeyens, José M., Cobos, Enrique J.

“…Background and Purpose Peripheral sensitization contributes to pathological pain. While prostaglandin E2 (PGE2) and nerve growth factor (NGF) sensitize…”
Get full text

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor by Rodríguez-Muñoz, María, Onetti, Yara, Cortés-Montero, Elsa, Garzón, Javier, Sánchez-Blázquez, Pilar

“…Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases,…”
Get full text

Chronic Pain Leads to Concomitant Noradrenergic Impairment and Mood Disorders by Alba-Delgado, Cristina, Llorca-Torralba, Meritxell, Horrillo, Igor, Ortega, Jorge E, Mico, Juan Antonio, Sánchez-Blázquez, Pilar, Meana, J. Javier, Berrocoso, Esther

“…Background Patients suffering chronic pain are at high risk of suffering long-lasting emotional disturbances characterized by persistent low mood and anxiety…”
Get full text

The Mu-Opioid Receptor and the NMDA Receptor Associate in PAG Neurons: Implications in Pain Control by RODRIGUEZ-MUNOZ, María, SANCHEZ-BLAZQUEZ, Pilar, VICENTE-SANCHEZ, Ana, BERROCOSO, Esther, GARZON, Javier

“…The capacity of opioids to alleviate inflammatory pain is negatively regulated by the glutamate-binding N-methyl-D-aspartate receptor (NMDAR). Increased…”
Get full text

Analgesic antidepressants promote the responsiveness of locus coeruleus neurons to noxious stimulation: Implications for neuropathic pain by Alba-Delgado, Cristina, Mico, Juan Antonio, Sánchez-Blázquez, Pilar, Berrocoso, Esther

“…The activity of locus coeruleus upon nociceptive stimulation is altered in neuropathic pain conditions, being restored by analgesic antidepressant treatment…”
Get full text

Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue by Cortés-Montero, Elsa, Rodríguez-Muñoz, María, Ruiz-Cantero, María Del Carmen, Cobos, Enrique José, Sánchez-Blázquez, Pilar, Garzón-Niño, Javier

“…Transient receptor potential ankyrin member 1 (TRPA1) belongs to the family of thermo TRP cation channels that detect harmful temperatures, acids and numerous…”
Get full text

Schizophrenia and depression, two poles of endocannabinoid system deregulation by Rodríguez-Muñoz, María, Sánchez-Blázquez, Pilar, Callado, Luis F., Meana, J. Javier, Garzón-Niño, Javier

“…The activity of certain G protein-coupled receptors (GPCRs) and of glutamate N -Methyl-D-aspartate receptors (NMDARs) is altered in both schizophrenia and…”
Get full text

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels by Cortés-Montero, Elsa, Sánchez-Blázquez, Pilar, Onetti, Yara, Merlos, Manuel, Garzón, Javier

“…The sigma 1 receptor (σ1R) and the mu-opioid receptor (MOR) regulate the transient receptor potential (TRP) V1 calcium channel. A series of proteins are…”
Get full text

Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling by Sánchez-Blázquez, Pilar, Rodríguez-Muñoz, María, Garzón, Javier

“…In periaqueductal grey (PAG) matter, cross-talk between the Mu-opioid receptor (MOR) and the glutamate N-methyl-D-Aspartate receptor (NMDAR)-CaMKII pathway…”
Get full text

The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception by Sánchez-Blázquez, Pilar, Cortés-Montero, Elsa, Rodríguez-Muñoz, María, Merlos, Manuel, Garzón-Niño, Javier

“…The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also…”
Get full text

The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain by Alba-Delgado, Cristina, Borges, Gisela, Sánchez-Blázquez, Pilar, Ortega, Jorge E., Horrillo, Igor, Mico, Juan A., Meana, J. Javier, Neto, Fani, Berrocoso, Esther

“…Rationale Peripheral neuropathic pain is a chronic condition that may produce plastic changes in several brain regions. The noradrenergic locus coeruleus (LC)…”
Get full text

SUMO-SIM interactions regulate the activity of RGSZ2 proteins by Garzón, Javier, Rodríguez-Muñoz, María, Vicente-Sánchez, Ana, García-López, María Ángeles, Martínez-Murillo, Ricardo, Fischer, Thierry, Sánchez-Blázquez, Pilar

“…The RGSZ2 gene, a regulator of G protein signaling, has been implicated in cognition, Alzheimer's disease, panic disorder, schizophrenia and several human…”
Get full text

Gz Mediates the Long-Lasting Desensitization of Brain CB1 Receptors and is Essential for Cross-Tolerance with Morphine by Garzón, Javier, de la Torre-Madrid, Elena, Rodríguez-Muñoz, María, Vicente-Sánchez, Ana, Sánchez-Blázquez, Pilar

“…Background Although the systemic administration of cannabinoids produces antinociception, their chronic use leads to analgesic tolerance as well as…”
Get full text

Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction by Rodríguez-Muñoz, María, Sánchez-Blázquez, Pilar, Merlos, Manuel, Garzón-Niño, Javier

“…Glutamate is probably the most important excitatory neurotransmitter in the brain. The glutamate N-methyl-D-aspartate receptor (NMDAR) is a calcium-gated…”
Get full text

The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9 by Sánchez-Blázquez, Pilar, Pozo-Rodrigálvarez, Andrea, Merlos, Manuel, Garzón, Javier

“…The glutamate N-methyl-D-aspartate receptor (NMDAR) plays an essential role in the excitotoxic neural damage that follows ischaemic stroke. Because the sigma-1…”
Get full text

Morphine Induces Endocytosis of Neuronal μ-opioid Receptors Through the Sustained Transfer of Gα Subunits to RGSZ2 Proteins by Rodríguez-Muñoz, María, de la Torre-Madrid, Elena, Sánchez-Blázquez, Pilar, Garzón, Javier

“…Background: In general, opioids that induce the recycling of μ-opioid receptors (MORs) promote little desensitization, although morphine is one exception to…”
Get full text

Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate by Sánchez-Blázquez, Pilar, Rodríguez-Muñoz, María, Vicente-Sánchez, Ana, Garzón, Javier

“…Overactivation of glutamate N-methyl-D-aspartate receptor (NMDAR) increases the cytosolic concentrations of calcium and zinc, which significantly contributes…”
Get more information

α N -Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers by Garzón-Niño, Javier, Cortés-Montero, Elsa, Rodríguez-Muñoz, María, Sánchez-Blázquez, Pilar

“…The opioid peptide β-endorphin coexists in the pituitary and brain in its -acetylated form, which does not bind to opioid receptors. We now report that these…”
Get full text

The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia by Sánchez-Blázquez, Pilar, Rodríguez-Muñoz, María, Garzón, Javier

“…The endocannabinoid system is widespread throughout the central nervous system and its type 1 receptor (CB1) plays a crucial role in preventing the…”
Get full text

RGS9 proteins facilitate acute tolerance to mu-opioid effects by Garzón, Javier, Rodríguez-Díaz, Marta, López-Fando, Almudena, Sánchez-Blázquez, Pilar

“…This paper reports that regulators of G‐protein signalling (RGS) proteins modulate the timing and amplitude of opioid signals by a push–pull mechanism. This is…”
Get full text